Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention

Autor: Baptiste, Beverly A., Katchur, Steven R., Fivenson, Elayne M., Croteau, Deborah L., Rumsey, William L., Bohr, Vilhelm A.

Publikováno v: In Free Radical Biology and Medicine 20 August 2018 124:149-162

NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Autor: Ryan, Eilise, Sadiku, Pranvera, Coelho, Patricia, Watts, Emily R, Zhang, Ailiang, Howden, Andrew J M, Sanchez Garcia, Manuel Alejandro, Bewley, Martin A., Cole, Joby, McHugh, Brian, Vermaelen, Wesley, Ghesquiere, Bart, Carmeliet, Peter, Rodriguez Blanco, Giovanny, von Kriegsheim, Alexander, Sanchez, Yolanda, Rumsey, William, Callahan, James F, Cooper, George, Parkinson, Nicholas, Baillie, J Kenneth, Cantrell, Doreen, McCafferty, John, Choudhury, Gourab, Singh, David, Dockrell, David H, Whyte, Moira K B, Walmsley, Sarah R

Publikováno v: Ryan, E, Sadiku, P, Coelho, P, Watts, E R, Zhang, A, Howden, A J M, Sanchez Garcia, M A, Bewley, M A, Cole, J, McHugh, B, Vermaelen, W, Ghesquiere, B, Carmeliet, P, Rodriguez Blanco, G, von Kriegsheim, A, Sanchez, Y, Rumsey, W, Callahan, J F, Cooper, G, Parkinson, N, Baillie, J K, Cantrell, D, McCafferty, J, Choudhury, G, Singh, D, Dockrell, D H, Whyte, M K B & Walmsley, S R 2023, ' NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD ', American Journal of Respiratory and Critical Care Medicine . https://doi.org/10.1164/rccm.202203-0482OC

Rationale: COPD (Chronic Obstructive Pulmonary Disease) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::fe09787fc19ea59a2ff88a8d7a9dc9ab
https://www.pure.ed.ac.uk/ws/files/323890313/Complete_AJRCCM_MS.pdf

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Design and optimization of cyclized NK 1 antagonists with controlled atropisomeric properties

Autor: Albert, Jeffrey S ^∗, Ohnmacht, Cyrus, Bernstein, Peter R, Rumsey, William L ^†, Aharony, David, Masek, Brian B ^‡, Dembofsky, Bruce T, Koether, Gerard M, Potts, William, Evenden, John L

Publikováno v: In Tetrahedron 2004 60(20):4337-4347

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