Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Rumiana, Bakalova"'
Autor:
Akira Sumiyoshi, Sayaka Shibata, Dessislava Lazarova, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova
Publikováno v:
Redox Report, Vol 28, Iss 1 (2023)
ABSTRACTObjectives: The present study describes a pharmacological strategy for the treatment of glioblastoma by redoxcycling ‘mitocans’ such as quinone/ascorbate combination drugs, based on their tumor-selective redox-modulating effects and toler
Externí odkaz:
https://doaj.org/article/4870639b8f2a41248188487048bdc3b6
Autor:
Milka Mileva, Lyudmila Dimitrova, Milena Popova, Vassya Bankova, Dimo Krastev, Hristo Najdenski, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova-Zheleva
Publikováno v:
International Journal Bioautomation, Vol 25, Iss 4, Pp 315-330 (2021)
Burkitt's lymphoma is a highly aggressive type of non-Hodgkin's lymphoma, linked to the Epstein-Barr virus, which induces oxidative stress and DNA damage in the infected cells. We investigated the cytotoxicity and redox-modulating ability of ethyl ac
Externí odkaz:
https://doaj.org/article/8484255641db455080ff17e3a3b25f3e
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102397- (2022)
Externí odkaz:
https://doaj.org/article/1f036ad967244d10b78c53f19daebc58
Publikováno v:
Redox Biology, Vol 53, Iss , Pp 102337- (2022)
Recent studies demonstrate that redox imbalance of NAD+/NADH and NADP+/NADPH pairs due to impaired respiration may trigger two “hidden” metabolic pathways on the crossroad between mitochondrial dysfunction, senescence, and proliferation: “β-ox
Externí odkaz:
https://doaj.org/article/b405a8941af6486cb7b90c823edb2f59
Autor:
Severina Semkova, Donika Ivanova, Biliana Nikolova, Genoveva Zlateva, Rumiana Bakalova, Zhivko Zhelev, Ichio Aoki
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1738-1744 (2021)
The combination drug menadione/ascorbate (M/A) manifests synergistic dose-dependent antiproliferative and cytotoxic effects towards cancer cells, but not towards normal cells of the same origin especially at concentrations that can be achieved in viv
Externí odkaz:
https://doaj.org/article/6c064c3a25db4957bde120bfd530a0e1
Autor:
Dessislava Lazarova, Sayaka Shibata, Itsuko Ishii, Genoveva Zlateva, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 33, Iss 1, Pp 294-301 (2019)
We used a mitochondria-penetrating nitroxide, mito-TEMPO, as a contrast probe for imaging of kidney dysfunction in mice, based on the redox-imbalance and oxidative stress in the renal tissues. Kidney dysfunction was triggered by hypercholesterolemia.
Externí odkaz:
https://doaj.org/article/c2ed0ada69e44e6a9a510dc947734f90
Autor:
SEVERINA SEMKOVA, BILIANA NIKOLOVA, IANA TSONEVA, GEORGI ANTOV, DONIKA IVANOVA, ANTON ANGELOV, ZHIVKO ZHELEV, RUMIANA BAKALOVA
Publikováno v:
Anticancer Research. 43:1207-1212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50cff829b59f698ef6311b2fd33a4e35
https://doi.org/10.21873/anticanres.16267
https://doi.org/10.21873/anticanres.16267
Autor:
DONIKA IVANOVA, SEVERINA SEMKOVA, ZVEZDELINA YANEVA, BILIANA NIKOLOVA, ZHIVKO ZHELEV, RUMIANA BAKALOVA, ICHIO AOKI
Publikováno v:
Anticancer Research. 43:1213-1220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac563332f1b699bd082298164b969899
https://doi.org/10.21873/anticanres.16268
https://doi.org/10.21873/anticanres.16268
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
Our graphical review expands the analysis of cancer vulnerabilities for high dose vitamin C, based on several facts, illustrating the cytotoxic potential of the ascorbate free radical (AFR) via impairment of mitochondrial respiration and the mechanis
Externí odkaz:
https://doaj.org/article/cfd0b9a2f90b48a1859eb116772172b8
Autor:
Donika Ivanova, Zhivko Zhelev, Plamen Getsov, Biliana Nikolova, Ichio Aoki, Tatsuya Higashi, Rumiana Bakalova
Publikováno v:
Redox Biology, Vol 16, Iss , Pp 352-358 (2018)
This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, “oncogenic” and “onco-suppressive” r
Externí odkaz:
https://doaj.org/article/53bc64d497b94ea6a20c06eebb6f8e3e