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Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitors V. A series of new derivatives containing a spiro[imidazo[1,2-a]pyrazine-2(3H),4'-piperidin]-5(1H)-one scaffold

Autor: Fumihiko Saitoh, Takafumi Mukaihira, Hidemitsu Nishida, Tsutomu Satoh, Akihiro Okano, Yasunobu Yumiya, Munetaka Ohkouchi, Rumi Johka, Tomokazu Matsusue, Ikuya Shiromizu, Yoshitaka Hosaka, Miwa Matsumoto, Shuhei Ohnishi

Publikováno v: Chemicalpharmaceutical bulletin. 54(11)

We have already reported unique compounds containing a N,O-spiro acetal structure as an orally active factor Xa (FXa) inhibitor. This time, we described a N,N-spiro acetal structure as an analogue of the N,O-spiro acetal structure for an orally activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9147a53159fa4f8c64f65f9d9d7b07
https://pubmed.ncbi.nlm.nih.gov/17077550

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