Výsledky vyhledávání - "Rumi, Ishisaka"

Transmembrane TNF (pro-TNF) is palmitoylated

Autor: Rumi Ishisaka, Toshihiko Utsumi, Yukimi Kira, Jim Klostergaard, Tomonori Takeshige, Kenji Tanaka, Kenji Takami

Publikováno v: FEBS Letters. 500:1-6

Human transmembrane tumor necrosis factor (pro-TNF) was examined for protein acylation. The cDNA encoding pro-TNF was expressed in both COS-1 cells and Sf9 cells and metabolic labeling with [3H]myristic or [3H]palmitic acid was attempted. The 17 kDa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d1369460d65895f6290fb6658e1426
https://doi.org/10.1016/s0014-5793(01)02576-5

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Amino Acid Residue Penultimate to the Amino-terminal Gly Residue Strongly Affects Two Cotranslational Protein Modifications, N-Myristoylation andN-Acetylation

Autor: Daisuke Takemura, Toshihiko Utsumi, Hiroyuki Iwata, Masahiro Sato, Kengo Nakano, Rumi Ishisaka

Publikováno v: Journal of Biological Chemistry. 276:10505-10513

To examine the amino-terminal sequence requirements for cotranslational protein N-myristoylation, a series of site-directed mutagenesis of N-terminal region were performed using tumor necrosis factor as a nonmyristoylated model protein. Subsequently,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d8d476467cdfe28791adec8528c16e
https://doi.org/10.1074/jbc.m006134200

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Activation of Caspase-3 by Lysosomal Cysteine Proteases and Its Role in 2,2'-Azobis-(2-Amidinopropane)Dihydrochloride (AAPH)--Induced Apoptosis in HL-60 Cells

Autor: Tamotsu Yoshioka, Rumi Ishisaka, Toshihiko Utsumi, Tomoko Kanno, Kozo Utsumi, Jitsuo Akiyama

Publikováno v: Journal of Biochemistry. 129:35-41

We previously reported that in addition to mitochondrial cytochrome c dependent activation, lysosomal cysteine proteases were also involved in the activation of caspase-3. In this study, we have separately obtained the lysosomal and mitochondrial cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b859c94a0a61aa26173be780c4efe40
https://doi.org/10.1093/oxfordjournals.jbchem.a002833

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Mechanism of α-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells

Autor: Rumi Ishisaka, Hirotsugu Kobuchi, Kayo Arita, Tomoko Kanno, Kozo Utsumi, Hiroshi Tamai, Shinji Yamamoto

Publikováno v: Free Radical Research. 33:407-418

Selective induction of apoptosis in tumor cells is important for treating patients with cancer. Because oxidative stress plays an important role in the process of apoptosis, we studied the effect of alpha-tocopheryl succinate (VES) on the fate of cul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511eb317645559309afafc99c2e5e40a
https://doi.org/10.1080/10715760000300941

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A Part of the Transmembrane Domain of pro-TNF Can Function as a Cleavable Signal Sequence That Generates a Biologically Active Secretory Form of TNF

Autor: Jim Klostergaard, Rumi Ishisaka, Tomonori Takeshige, Noriyuki Sato, Kenji Tanaka, Hiroyuki Iwata, Toshihiko Utsumi

Publikováno v: Journal of Biochemistry. 126:413-420

To determine the minimum requirement in the 76-residue leader sequence of pro-tumor necrosis factor (TNF) for membrane translocation across the endoplasmic reticulum (ER) and for the maturation of pro-TNF, we constructed pro-TNF mutants in which a pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85729a572ef683059dcee06ded7f2b91
https://doi.org/10.1093/oxfordjournals.jbchem.a022466

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Resistance to nitric oxide-mediated apoptosis in HL-60 variant cells is associated with increased activities of Cu,Zn-superoxide dismutase and catalase

Autor: Kozo Utsumi, Rumi Ishisaka, Tatsuji Yasuda, Tamotsu Yoshioka, Munehisa Yabuki, Alan A. Horton, Shinji Kariya

Publikováno v: Free Radical Biology and Medicine. 26:325-332

Nitric oxide (NO) released from (Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1- ium-1,2-diolate (DETA/NO or NOC-18) induces apoptosis in human leukemia HL-60 cells. In this study, we isolated a HL-60 variant cell line, HL-NR6, that is resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e973eb6327ba04b14662dd90694add46
https://doi.org/10.1016/s0891-5849(98)00203-2

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Effects of Milk and Colostrum on Superoxide Generation of Oral Polymorphonuclear Neutrophils and the Changes That Occur during Storage at Low Temperature

Autor: Tatsuji Yasuda, Tamotsu Yoshioka, Tomoko Kanno, Rumi Ishisaka, Hiroshi Kanematsu, Alan A. Horton, Hiroko Nakahara, Jitsuo Akiyama

Publikováno v: Neonatology. 76:331-339

Human oral polymorphonuclear neutrophils (OPMN) generate reactive oxygen species even in the absence of stimulants. Because OPMN from newborn babies are exposed to colostrum and mature milk, the biological properties of these cells including the gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a5112574d048057999bcd88266f706
https://doi.org/10.1159/000014176

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Activation of caspase-3-like protease by digitonin-treated lysosomes

Autor: Rumi Ishisaka, Masayasu Inoue, Munehisa Yabuki, Kozo Utsumi, Toshihiko Utsumi, Tomoko Kanno, Takashi Furuno

Publikováno v: FEBS Letters. 435:233-236

Apoptosis, a naturally occurring programmed cell death or cell `suicide', has been paid much attention as one of the critical mechanisms for morphogenesis and tissue remodeling. Activation of cysteine aspartases (caspases) is one of the critical step

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beaf1fa835f47f5af52bbfa2a55f3f2c
https://doi.org/10.1016/s0014-5793(98)01080-1

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