Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ruli Ge"'
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease that commonly results in nontraumatic disability in young adults. The characteristic pathological hallmark of MS is damage to myelin, oligodendrocytes, and axons. Microglia prov
Externí odkaz:
https://doaj.org/article/44e5b9afeae8439baee0418ab83f160d
Autor:
Mengdi Wang, Hongxia Wang, Jing Wang, Shujun Lu, Chen Li, Xiaofei Zhong, Nan Wang, Ruli Ge, Qi Zheng, Jinbo Chen, Hongcai Wang
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Background: Increased iron deposition in nigrosome as assessed by susceptibility-weighted imaging (SWI) is involved in the pathogenesis of Parkinson’s disease (PD). This study investigated the effects of antiparkinson drugs on iron deposition in th
Externí odkaz:
https://doaj.org/article/6affb00986414ce2b04a4a846e00f3c6
Publikováno v:
Mediators of Inflammation, Vol 2021 (2021)
Follicular helper CD4+ T (TFH) cells are a specialized subset of effector T cells that play a central role in orchestrating adaptive immunity. TFH cells mainly promote germinal center (GC) formation, provide help to B cells for immunoglobulin affinit
Externí odkaz:
https://doaj.org/article/d2367afd31ff483ca020262441b2ec98
Publikováno v:
Clinical and Experimental Otorhinolaryngology, Vol 10, Iss 4, Pp 303-308 (2017)
Objectives To investigate the otoprotective effects of mouse nerve growth factor (mNGF) in A/J mice. Methods The mice at postnatal day 7 (P7) were randomly separated into a mNGF treated group (mNGF group) and a distilled water (for injection) treated
Externí odkaz:
https://doaj.org/article/c954d110160e480599dea28d4b07d97f
Autor:
Xu Han, Ruli Ge, Gang Xie, Ping Li, Xin Zhao, Lixiang Gao, Heng Zhang, Oumei Wang, Fei Huang, Fengchan Han
Publikováno v:
ASN Neuro, Vol 7 (2015)
A/J and C57BL/6 J (B6) mice share a mutation in Cdh23 ( ahl allele) and are characterized by age-related hearing loss. However, hearing loss occurs much earlier in A/J mice at about four weeks of age. Recent study has revealed that a mutation in citr
Externí odkaz:
https://doaj.org/article/e044c52450464f9da607b98caeb6f1cd
Publikováno v:
Clinical Neurology and Neurosurgery. 226:107614
The evaluation of genetic predisposition for early cerebral infarction(ECI)may contribute to the recognition of individuals at increased risks and thereby prevent CI in clinical practice. The study was to investigate genetic risk of ECI with ischemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d9ac6fd608047e4ca3a7e81376fd92
https://doi.org/10.21203/rs.3.rs-1410294/v1
https://doi.org/10.21203/rs.3.rs-1410294/v1
Autor:
Ningning Zhang, Qi Zheng, Hongcai Wang, Yong Fu, Yan Chen, Yiwei Hou, Chao Chen, Jinbo Chen, Ruli Ge, Dujuan Ji
Publikováno v:
NeuroReport. 29:1201-1208
α-Synuclein (α-syn) aggregation has far-reaching implications in the pathogenesis of Parkinson's disease, and the levels of α-syn protein determine its neurotoxic potential. However, the intrinsic pathway of α-syn accumulation and the mode of α-
Autor:
Jiaolong Yang, Ruofei Du, Ruli Ge, Jinbo Chen, Fang Chen, Yan Chen, Yiwei Hou, Chao Chen, Hongcai Wang
Publikováno v:
Neuroscience. 388:367-373
For Parkinson's disease (PD), the regulatory mechanism of α-synuclein (α-syn) aggregation remains to be clarified. Ubiquitination modification is crucial for α-syn aggregation, with implications for Lewy body formation. Besides, ubiquitin ligase a
Publikováno v:
Restorative neurology and neuroscience. 36(5)
Background Protective effect of roscovitine and deregulation of the p-RB/E2F1 have not been well studied in PD models generated by repeated oral administration of rotenone. Objective These experiments evaluated the effects of repeated oral gavage of