Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Rule of 5"'
Autor:
Tchamova Albena, Dezert Jean, Bocheva Nadejda, Konstantinova Pavlina, Genova Bilyana, Stefanova Miroslava
Publikováno v:
Cybernetics and Information Technologies, Vol 21, Iss 1, Pp 73-86 (2021)
The paper presents a study on the human learning process during the classification of stimuli, defined by motion and color visual cues and their combination. Because the classification dimension and the features that define each category are uncertai
Externí odkaz:
https://doaj.org/article/ce6a3e99e1d24cff99e6c7b13cbbffcb
Akademický článek
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Autor:
Yunhai Cui, Cyril Desevaux, Ines Truebenbach, Peter Sieger, Klaus Klinder, Alan Long, Achim Sauer
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1146 (2021)
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involv
Externí odkaz:
https://doaj.org/article/450fe8cfeded4f9c92c2b29b6ac8c182
Akademický článek
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Autor:
Giulia Caron, Jan Kihlberg, Giuseppe Ermondi, Vasanthanathan Poongavanam, Gilles H. Goetz, Ekaterina L. Ratkova
Publikováno v:
ACS Med Chem Lett
[Image: see text] An increasing number of drug discovery programs concern compounds in the beyond rule of 5 (bRo5) chemical space, such as cyclic peptides, macrocycles, and degraders. Recent results show that common paradigms of property-based drug d
Publikováno v:
Journal of Advanced Pharmaceutical Technology & Research, Vol 3, Iss 1, Pp 57-61 (2012)
Isatin is an endogenous compound and reported to possess a wide range of biological activities. Numerous papers have shown that the pyridyl-2-amidrazone nucleus possesses a potent antimicrobial activity . Based on these prior observations, we postula
Externí odkaz:
https://doaj.org/article/97c04b22a9c842eaa229ae967f87828c
Publikováno v:
ADMET and DMPK, Vol 9, Iss 3 (2021)
ADMET and DMPK
Volume 9
Issue 3
ADMET and DMPK
Volume 9
Issue 3
Fraction Lipophicity Index (FLI) has been developed as a composite drug-like metric combining logP and logD in a weighted manner. In the present study an extended data set confirmed the previously established drug-like FLI range 0-8 using two calcula
Autor:
Peter Sieger, Cyril Desevaux, Ines Truebenbach, Klaus Klinder, Alan Long, Achim Sauer, Yunhai Cui
Publikováno v:
Pharmaceutics, Vol 13, Iss 1146, p 1146 (2021)
Pharmaceutics
Volume 13
Issue 8
Pharmaceutics
Volume 13
Issue 8
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport proteins involv
Autor:
Serpil Eryılmaz
Publikováno v:
Volume: 22, Issue: 6 1638-1647
Sakarya University Journal of Science
Sakarya University Journal of Science
In this study, global reactivity descriptors such as ionization potential, electron affinity, electronegativity, chemical hardness, softness and electrophilicity index of norbornadiene derivatives which include some halogen atoms and atom groups, hav
Autor:
Dirk Menche
Publikováno v:
Chemmedchem
Natural products provide important lead structures for development of pharmaceutical agents or present attractive tools for medicinal chemistry. However, structurally complex and thus less accessible metabolites defying conventional drug‐like prope