Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rujuta Yashodhan, Gadgil"'
Autor:
Stanley Dean Rider, French J. Damewood, Rujuta Yashodhan Gadgil, David C. Hitch, Venicia Alhawach, Resha Shrestha, Matilyn Shanahan, Nathen Zavada, Michael Leffak
Publikováno v:
Genes
Volume 14
Issue 2
Pages: 398
Volume 14
Issue 2
Pages: 398
Short tandem DNA repeats are drivers of genome instability. To identify suppressors of break-induced mutagenesis human cells, unbiased genetic screens were conducted using a lentiviral shRNA library. The recipient cells possessed fragile non-B DNA th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d94a0733e22bf786421a2757a61b6c9
Autor:
René M. Linka, Todd Lewis, Paul R. Andreassen, Joanna Barthelemy, Feng Zhang, Elizabeth L. Virts, Felicia M. Kennedy, Rujuta Yashodhan Gadgil, Constanze Wiek, Michael Leffak, Helmut Hanenberg
Publikováno v:
Nucleic Acids Research
The primary function of the UBE2T ubiquitin conjugase is in the monoubiquitination of the FANCI-FANCD2 heterodimer, a central step in the Fanconi anemia (FA) pathway. Genetic inactivation of UBE2T is responsible for the phenotypes of FANCT patients;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64ac306774afc22be28fec62515c953
http://europepmc.org/articles/PMC6468168
http://europepmc.org/articles/PMC6468168
Autor:
S. Dean Rider, Rujuta Yashodhan Gadgil, David C. Hitch, French J. Damewood, Nathen Zavada, Matilyn Shanahan, Venicia Alhawach, Resha Shrestha, Kazuo Shin-ya, Michael Leffak
Publikováno v:
Journal of Biological Chemistry. 298:101947
G-quadruplex (G4)-prone structures are abundant in mammalian genomes, where they have been shown to influence DNA replication, transcription, and genome stability. In this article, we constructed cells with a single ectopic homopurine/homopyrimidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6647b269fb70a559ab06211d1bb06a
https://doi.org/10.1016/j.jbc.2022.101947
https://doi.org/10.1016/j.jbc.2022.101947
Autor:
Kazuo Shin-ya, Michael Leffak, Helmut Hanenberg, Joanna Barthelemy, Eric J. Romer, French J. Damewood, Rujuta Yashodhan Gadgil, Caitlin C. Goodman, S. Dean Rider
Publikováno v:
J Biol Chem
Short tandemly repeated DNA sequences, termed microsatellites, are abundant in the human genome. These microsatellites exhibit length instability and susceptibility to DNA double-strand breaks (DSBs) due to their tendency to form stable non-B DNA str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb6ade166034d57c32f3ad98c17bd825
https://www.ncbi.nlm.nih.gov/pubmed/32873711
https://www.ncbi.nlm.nih.gov/pubmed/32873711
Publikováno v:
Biophysical Chemistry. 225:38-48
Microsatellites are short, tandemly repeated DNA motifs of 1–6 nucleotides, also termed simple sequence repeats (SRSs) or short tandem repeats (STRs). Collectively, these repeats comprise approximately 3% of the human genome Subramanian et al. (200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431cd9e8abe7f91e89e679c110635334
https://doi.org/10.1016/j.bpc.2016.11.007
https://doi.org/10.1016/j.bpc.2016.11.007
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2056
Expansions of CNG microsatellite tracts are responsible for several neurodegenerative diseases, including myotonic dystrophy type 1, Huntington disease, and spinocerebellar ataxia type 8. Here we show that expanded (CNG)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84ceb7ae6dc398924c465b7ce7c432e0
https://pubmed.ncbi.nlm.nih.gov/31586345
https://pubmed.ncbi.nlm.nih.gov/31586345
Publikováno v:
Methods in Molecular Biology ISBN: 9781493997831
Expansions of CNG microsatellite tracts are responsible for several neurodegenerative diseases, including myotonic dystrophy type 1, Huntington disease, and spinocerebellar ataxia type 8. Here we show that expanded (CNG)n repeats are susceptible not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdea909757b00ea2ff87afe5557a3206
https://doi.org/10.1007/978-1-4939-9784-8_8
https://doi.org/10.1007/978-1-4939-9784-8_8