Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rujuta A Bam"'
Autor:
Mini Balakrishnan, Stephen R Yant, Luong Tsai, Christopher O'Sullivan, Rujuta A Bam, Angela Tsai, Anita Niedziela-Majka, Kirsten M Stray, Roman Sakowicz, Tomas Cihlar
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74163 (2013)
HIV-1 integrase (IN) is the target for two classes of antiretrovirals: i) the integrase strand-transfer inhibitors (INSTIs) and ii) the non-catalytic site integrase inhibitors (NCINIs). NCINIs bind at the IN dimer interface and are thought to interfe
Externí odkaz:
https://doaj.org/article/ab7f85858d794836a0e3f22e87f9d8d3
Autor:
Hu Li, Jin Xia, Dimitri Bennett, Fatima Roque, Rujuta A. Bam, Ana Bárbara Tadeu Tavares, Mugdha Gokhale, Fidelia Ida, Jinnie Jiwon Rhee, Montse Soriano Gabarro, Yiqing Song
Publikováno v:
Therapeutic Advances in Infectious Disease, Vol 10 (2023)
Background: A growing interest in long-term sequelae of COVID-19 has prompted several systematic literature reviews (SLRs) to evaluate long-COVID-19 effects. However, many of these reviews lack in-depth information on the timing, duration, and severi
Externí odkaz:
https://doaj.org/article/b5a9d8cdc0b24fc69d9e5a27ae3f8e4a
Autor:
David A. Wohl, Aprille A. Espinueva, Lauren Dau, Chen-Yu Wang, Alexandra Lachmann, Rujuta A. Bam, Aaditya Rawal, Kerris Chappell-Smith, Juergen K. Rockstroh
Publikováno v:
ERJ Open Research, Vol 8, Iss 4 (2022)
Owing to condensed development processes, expanding evidence and differences in healthcare system characteristics, many COVID-19 guidelines differ in their quality and treatment recommendations, which has consequences for clinical practice. This revi
Externí odkaz:
https://doaj.org/article/3806ddb353ed461a9063df18df9957d5
Autor:
Qi Liu, Chien-Hung Chou, Eda Canales, Roman Sakowicz, Steven Bondy, Tomas Cihlar, Albert Liclican, Diana M. Brainard, Anita Niedziela-Majka, William Rowe, Nikolai Novikov, Shekeba Ahmadyar, John R. Somoza, Randall L. Halcomb, Cheryl K. McDonald, Carina E. Cannizzaro, Nicolas Margot, Debi Jin, George Stepan, Qiaoyin Wu, Eric Hu, Judy Mwangi, Stephanie A. Leavitt, Todd C. Appleby, Robert L. Anderson, Scott E. Lazerwith, Schroeder Scott D, Tse Winston C, Gediminas Brizgys, Rebecca Begley, Yili Xu, Scott Sellers, Scott A. Wolckenhauer, Wesley I. Sundquist, Derek Hansen, Philip Morganelli, Andrew Mulato, Sheila Clancy, Xiaohong Liu, Anna Chiu, Eric S. Daar, Renee R. Ram, S. Swaminathan, Anne E. Chester, Melanie H. Wong, Ya-Pei Liu, John O. Link, Michael Graupe, Luong K. Tsai, Christian Callebaut, Latesh Lad, William E. Lee, Rujuta A. Bam, Terrence Z. Cai, Bing Lu, John K. Ling, Roland D. Saito, Magdeleine Hung, Armando G. Villaseñor, Peter Ruane, Nikos Pagratis, Martin S. Rhee, David Koditek, Gordon Crofoot, Giuseppe A. Papalia, Stephen R. Yant, Rob Hyland, Helen Yu, Jim Zheng, Jennifer R. Zhang, Gary I. Sinclair, Jiayao Li, Eric Singer
Publikováno v:
Nature
Oral antiretroviral agents provide life-saving treatments for millions of people living with HIV, and can prevent new infections via pre-exposure prophylaxis1–5. However, some people living with HIV who are heavily treatment-experienced have limite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5892a90808b40581a09439f9529aaaa6
https://doi.org/10.1038/s41586-020-2443-1
https://doi.org/10.1038/s41586-020-2443-1
Autor:
Kuoting Wu, Clifford Wong, Margaret Neighbors, Erik E. Karrer, Yasuyuki Higashi, Madan M. Paidhungat, Steven J. Chapin, Steven H. Bass, Bruce H. Devens, Shinsuke Oshima, Margaret Reed, Brent R. Larsen, Yonghong Chen, Francisco A. Anderson, Marc Whitlow, Rujuta A. Bam, Sridhar Viswanathan, Rong A. Fan, Qian Zhang
Publikováno v:
Protein Engineering Design and Selection. 29:159-167
The CTLA4-Ig therapeutics abatacept and belatacept inhibit CD28-mediated T cell activation by binding CD80 (B7-1) and CD86 (B7-2) co-stimulatory ligands. Both compounds preferentially bind CD80, yet CD86 has been implicated as the dominant co-stimula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16578a205d00bb45328a4431b02b5c0
https://doi.org/10.1093/protein/gzw002
https://doi.org/10.1093/protein/gzw002
Autor:
Rujuta A. Bam, Luong Tsai, Kirsten M. Stray, Madeleine Willkom, Gabriel Birkus, Tomas Cihlar, Christian R. Frey, Stephen R. Yant
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:316-322
Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV). Previous studies suggested a principal role for the lysosomal serine protease cathepsin A (CatA) in the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70e847c93d1018d75dd66f963ec56336
https://doi.org/10.1128/aac.01834-15
https://doi.org/10.1128/aac.01834-15
Autor:
Tomas Cihlar, Andrew Mulato, Derek Hansen, Joseph Hesselgesser, Rujuta A. Bam, Alivelu Irrinki, Stephen R. Yant, Gregg S. Jones, Christian R. Frey
Publikováno v:
Antimicrobial Agents and Chemotherapy
GS-9620 is a potent and selective oral Toll-like receptor 7 (TLR7) agonist that directly activates plasmacytoid dendritic cells (pDCs). GS-9620 suppressed hepatitis B virus (HBV) in animal models of chronic infection and transiently activated HIV exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bed99910500a2eaae76627a1fcc88401
https://doi.org/10.1128/aac.01369-16
https://doi.org/10.1128/aac.01369-16
Publikováno v:
Antiviral Therapy. 19:687-692
Background Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir that shows enhanced antiretroviral effect and reduced plasma tenofovir exposures at approximately one-tenth the clinically approved dose of tenofovir disoproxil fumarate (TDF). Te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d585cb4750742fd9e1ec3c91c84e16
https://doi.org/10.3851/imp2770
https://doi.org/10.3851/imp2770
Publikováno v:
Antiviral therapy. 19(7)
Background Tenofovir alafenamide (TAF) is a novel investigational prodrug of tenofovir (TFV) that permits enhanced delivery of TFV into peripheral blood mono-nuclear cells (PBMCs) and lymphatic tissues. A critical step in the intracellular metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9488597bc95c05bd8d06197df1c4760c
https://pubmed.ncbi.nlm.nih.gov/24625459
https://pubmed.ncbi.nlm.nih.gov/24625459
Autor:
Tomas Cihlar, Jia Hao, Kirsten M. Stray, Stephen R. Yant, Adrian S. Ray, Rujuta A. Bam, Gabriel Birkus, Eve-Irene Lepist
A once-daily single-tablet antiretroviral regimen containing tenofovir (TFV) disoproxil fumarate, emtricitabine (FTC), elvitegravir (EVG), and cobicistat (COBI) is an approved combination for the treatment of patients infected with HIV. COBI and TFV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0caec3e59526bfa9b1bdc7fb5257b59
https://europepmc.org/articles/PMC3811427/
https://europepmc.org/articles/PMC3811427/
