Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rujia Dai"'
Autor:
Kangli Wang, Rujia Dai, Yan Xia, Jianghua Tian, Chuan Jiao, Tatiana Mikhailova, Chunling Zhang, Chao Chen, Chunyu Liu
Publikováno v:
Epigenetics, Vol 17, Iss 10, Pp 1110-1127 (2022)
DNA methylation (DNAm) that occurs on promoter regions is primarily considered to repress gene expression. Previous studies indicated that DNAm could also show positive correlations with gene expression. Both DNAm and gene expression profiles are kno
Externí odkaz:
https://doaj.org/article/85034ee54e114fa99caea54930176900
Autor:
Yunting Zhu, Maree J. Webster, Caitlin E. Murphy, Frank A. Middleton, Paul T. Massa, Chunyu Liu, Rujia Dai, Cyndi Shannon Weickert
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Approximately 40% of people with schizophrenia are classified as having “high inflammation.” This subgroup has worse neuropathology than patients with “low inflammation.” Thus, one would expect the resident microglia and possibly monocyte-der
Externí odkaz:
https://doaj.org/article/73e83ffade6b4cb7bee7ea95c2f2594a
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 17, Iss 4, Pp 402-414 (2019)
Neuropsychiatric disorders affect hundreds of millions of patients and families worldwide. To decode the molecular framework of these diseases, many studies use human postmortem brain samples. These studies reveal brain-specific genetic and epigeneti
Externí odkaz:
https://doaj.org/article/8c513ad446c14805840720f910ef6524
Autor:
Jiacheng Dai, Yu Chen, Rujia Dai, Yi Jiang, Jianghua Tian, Sihan Liu, Meng Xu, Miao Li, Jiaqi Zhou, Chunyu Liu, Chao Chen
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Agonal factors, the conditions that occur just prior to death, can impact the molecular quality of postmortem brains, influencing gene expression results. Our study used gene expression data of 262 samples from ROSMAP with the detailed terminal state
Externí odkaz:
https://doaj.org/article/bc53f850eedd422cb332df2ec140b3f2
Autor:
Rujia Dai1, Tianyao Chu2, Ming Zhang2, Xuan Wang2, Jourdon, Alexandre3, Feinan Wu3, Mariani, Jessica3, Vaccarino, Flora M.3,4, Donghoon Lee5, Fullard, John F.5, Hoffman, Gabriel E.5, Roussos, Panos5, Yue Wang6, Xusheng Wang7, Pinto, Dalila8, Wang, Sidney H.9, Chunling Zhang10, Chao Chen2, Chunyu Liu1,2,10 liuch@upstate.edu
Publikováno v:
Science Advances. 5/24/2024, Vol. 10 Issue 21, p1-13. 13p.
Autor:
Rujia Dai
Sample-wise deconvolution methods estimate cell-type proportions and gene expressions in bulk-tissue samples, yet their performance and biological applications remain unexplored, particularly in human brain transcriptomic data. Here, nine deconvoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b9500d5b1edf8839ca09984117ab59
Autor:
Le Wang, Vincent R. Mirabella, Rujia Dai, Xiao Su, Ranjie Xu, Azadeh Jadali, Matteo Bernabucci, Ishnoor Singh, Yu Chen, Jianghua Tian, Peng Jiang, Kevin Y. Kwan, ChangHui Pak, Chunyu Liu, Davide Comoletti, Ronald P. Hart, Chao Chen, Thomas C. Südhof, Zhiping P. Pang
Publikováno v:
Molecular Psychiatry.
Mutations in many synaptic genes are associated with autism spectrum disorders (ASDs), suggesting that synaptic dysfunction is a key driver of ASD pathogenesis. Among these mutations, the R451C-substitution in the NLGN3 gene that encodes the postsyna
Autor:
Rujia Dai, Richard F. Kopp, Chunling Zhang, Yi Jiang, Shishi Min, Ma-Li Wong, Wei-Dong Yao, Chunyu Liu, Hongyu Ruan, Chao Chen, Yan Xia, Qingtuan Meng, Chaodong Ding, Liz Kuney, Le Wang
Publikováno v:
Molecular psychiatry
Schizophrenia (SCZ) is a neuropsychiatric disorder with aberrant expression of multiple genes. However, identifying its exact causal genes remains a considerable challenge. The brain-specific transcription factor POU3F2 (POU domain, class 3, transcri
Alternative splicing (AS) contributes to the increased cellular and functional tissue complexity that is substantial in the brain. AS is tightly regulated because it is critical to many biological processes. Defective splicing is observed in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ca35a68476d0ab956977af6f70d192
https://doi.org/10.21203/rs.3.rs-1184033/v1
https://doi.org/10.21203/rs.3.rs-1184033/v1
Autor:
Kangli Wang, Chunling Zhang, Chuan Jiao, Jianghua Tian, Rujia Dai, Yan Xia, Chao Chen, Chunyu Liu, Tatiana Mikhailova
Publikováno v:
Epigenetics
DNA methylation (DNAm) that occurs on promoter regions is primarily considered to repress gene expression. Previous studies indicated that DNAm could also show positive correlations with gene expression. Both DNAm and gene expression profiles are kno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45d8a16e489350de02d902d727a91794
https://doi.org/10.1101/2021.05.12.443776
https://doi.org/10.1101/2021.05.12.443776