GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Autor: Lagou V; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium., Jiang L; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Ulrich A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., Zudina L; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., González KSG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica., Balkhiyarova Z; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK., Faggian A; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy., Maina JG; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Chen S; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Todorov PV; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Sharapov S; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., David A; Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK., Marullo L; Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rujan RM; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Gao Η; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK., Εvangelou Ε; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Benyamin B; Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.; Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Isaacs A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.; Department of Physiology, Maastricht University, Maastricht, the Netherlands., Zhao JH; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Willems SM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Johnson T; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Gieger C; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Grallert H; Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Meisinger C; Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany., Strawbridge RJ; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK., Goel A; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Rybin D; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Albrecht E; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Jackson AU; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Corrêa IR Jr; New England Biolabs, Ipswich, MA, USA., Farber-Eger E; Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Uitterlinden AG; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Munroe PB; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Brown MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Schmidberger J; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Holmen O; Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Hveem K; K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway., Wilsgaard T; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Wang Z; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Shmeliov A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK., den Hoed M; The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA., Kratzer W; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Haenle M; Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany., Koenig W; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany., Boehm BO; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore., Tan TM; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK., Tomas A; Section of Cell Biology and Functional Genomics, Imperial College London, London, UK., Salem V; Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK., Barroso I; Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK., Tuomilehto J; Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Florez JC; Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Hamsten A; Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.; Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden., Watkins H; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Njølstad I; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.; Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway., Wichmann HE; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Caulfield MJ; Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Khaw KT; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., van Duijn CM; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Centre for Medical Systems Biology, Leiden, the Netherlands.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Hofman A; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Whitfield JB; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia., Montgomery G; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia., Scapoli C; Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy., Tzoulaki I; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Elliott P; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.; MRC Centre for Environment and Health, Imperial College London, London, UK.; National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK., Thorsteinsdottir U; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Stefansson K; deCODE genetics/Amgen, Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavík, Iceland., Brittain EL; Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Froguel P; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France., Sexton PM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wootten D; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Groop L; Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.; Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Deganutti G; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK., Demirkan A; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.; Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands., Pers TH; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark., Reynolds CA; Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.; School of Life Sciences, University of Essex, Colchester, UK., Aulchenko YS; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.; Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.; MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia., Kaakinen MA; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk., Jones B; Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk., Prokopenko I; Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.; UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.

Publikováno v: Nature genetics [Nat Genet] 2023 Sep; Vol. 55 (9), pp. 1448-1461. Date of Electronic Publication: 2023 Sep 07.

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist.

Autor: Pickford P; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Lucey M; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Rujan RM; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK., McGlone ER; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Bitsi S; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Ashford FB; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK., Corrêa IR; New England Biolabs, Ipswich, MA, USA., Hodson DJ; Institute of Metabolism and Systems Research (IMSR) and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK., Tomas A; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Deganutti G; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK., Reynolds CA; Centre for Sport, Exercise, and Life Sciences, Faculty of Health and Life Sciences, Coventry University, Alison Gingell Building, CV1 5FB, UK; School of Life Sciences, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK., Owen BM; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Tan TM; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Minnion J; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK., Jones B; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK. Electronic address: ben.jones@imperial.ac.uk., Bloom SR; Section of Endocrinology and Investigative Medicine, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, W12 0NN, UK.

Publikováno v: Molecular metabolism [Mol Metab] 2021 Sep; Vol. 51, pp. 101242. Date of Electronic Publication: 2021 Apr 30.

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors.

Autor: Hendrikse ER; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Liew LP; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand., Bower RL; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Bonnet M; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand., Jamaluddin MA; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Prodan N; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand., Richards KD; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand., Walker CS; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Pairaudeau G; Hit Discovery, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom., Smith DM; Emerging Innovations, Discovery Sciences, R&D, AstraZeneca, Cambridge CB2 0SL, United Kingdom., Rujan RM; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Sudra R; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Reynolds CA; School of Life Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom., Booe JM; Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Pioszak AA; Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, United States., Flanagan JU; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Hay MP; Auckland Cancer Society Research Centre, University of Auckland, Auckland 1023, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand., Hay DL; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, Auckland 1010, New Zealand.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2020 Mar 12; Vol. 3 (2), pp. 305-320. Date of Electronic Publication: 2020 Mar 12 (Print Publication: 2020).