Three-Dimensional Cell Cultures as a Model System to Evaluate the Biological Activity of Gemcitabine (2′, 2′-Difluoro-2′deoxycytidine).

Autor: Peters, Godefridus J., Smitskamp-Wilms, Evelien, Veerman, Gijsbert, Pizao, Paulo E., Ruiz van Haperen, Veronique W. T., Pinedo, Herbert M.

Publikováno v: Nucleosides & Nucleotides; May1995, Vol. 14 Issue 3-5, p661-664, 4p

Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine.

Autor: Honeywell RJ; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands., Ruiz van Haperen VW; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands; Advisory Council on Health Research, PO Box 16052, 2500 BB The Hague, The Netherlands., Veerman G; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands; INC research, Amsterdam, The Netherlands., Smid K; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands., Peters GJ; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: gj.peters@vumc.nl.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2015 Mar; Vol. 60, pp. 73-81. Date of Electronic Publication: 2015 Jan 03.

In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant.

Autor: Bergman AM; Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Eijk PP, Ruiz van Haperen VW, Smid K, Veerman G, Hubeek I, van den Ijssel P, Ylstra B, Peters GJ

Publikováno v: Cancer research [Cancer Res] 2005 Oct 15; Vol. 65 (20), pp. 9510-6.