Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine.

Autor: Honeywell RJ; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands., Ruiz van Haperen VW; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands; Advisory Council on Health Research, PO Box 16052, 2500 BB The Hague, The Netherlands., Veerman G; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands; INC research, Amsterdam, The Netherlands., Smid K; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands., Peters GJ; Department of Medical Oncology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands. Electronic address: gj.peters@vumc.nl.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2015 Mar; Vol. 60, pp. 73-81. Date of Electronic Publication: 2015 Jan 03.

[The Health Council of the Netherlands' advice 'A closer look at Lyme disease'].

Autor: Ruiz van Haperen VW; Gezondheidsraad, Den Haag, the Netherlands. v.ruiz@gr.nl, Dondorp CA, Groeneveld K

Publikováno v: Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2013; Vol. 157 (29), pp. A6613.

Pancreatic ductal adenocarcinoma: the latest on diagnosis, molecular profiling, and systemic treatments.

Autor: Bugazia, Doaa, Al-Najjar, Ebtesam, Esmail, Abdullah, Abdelrahim, Saifudeen, Abboud, Karen, Abdelrahim, Adham, Umoru, Godsfavour, Rayyan, Hashem A., Abudayyeh, Ala, Al Moustafa, Ala-Eddin, Abdelrahim, Maen

Publikováno v: Frontiers in Oncology; 2024, p1-16, 16p

Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel.

Autor: Wei, Mengyan^1,2 (AUTHOR), Wang, Pu^1,2 (AUTHOR), Zhu, Xiufang^1,2 (AUTHOR), Morishima, Masaki³ (AUTHOR), Liu, Yangong^1,2 (AUTHOR), Zheng, Mingqi¹ (AUTHOR), Liu, Gang¹ (AUTHOR), Osanai, Hiroki² (AUTHOR), Yoshimura, Kenshi² (AUTHOR), Kume, Shinichiro² (AUTHOR), Kurokawa, Tatsuki² (AUTHOR), Ono, Katsushige² (AUTHOR) ono@oita-u.ac.jp

Publikováno v: PLoS ONE. 2/2/2023, Vol. 17 Issue 2, p1-22. 22p.

Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.

Autor: Bergman AM; Department of Oncology, University Hospital VU, Amsterdam, The Netherlands., Pinedo HM, Jongsma AP, Brouwer M, Ruiz van Haperen VW, Veerman G, Leyva A, Eriksson S, Peters GJ

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 1999 Feb 15; Vol. 57 (4), pp. 397-406.