Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Ruiz Altaba, Ariel"'
1
A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12
Autor: Duquet, Arnaud, Melotti, Alice, Mishra, Sonakshi, Malerba, Monica, Seth, Chandan, Conod, Arwen, Ruiz Altaba, Ariel
Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol. 6, No 7 (2014) pp. 882-901
The progression of tumors to the metastatic state involves the loss of metastatic suppressor functions. Finding these, however, is difficult as in vitro assays do not fully predict metastatic behavior, and the majority of studies have used cloned cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6ae57d73be8e79c7371b176c166363a1
http://europepmc.org/articles/PMC4119353
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2
Hedgehog signaling and the Gli code in stem cells, cancer, and metastases
Autor: Ruiz Altaba, Ariel
Publikováno v: Science Signaling, Vol. 4, No 200 (2011) P. pt9
The Hedgehog (Hh)-Gli signaling pathway is an essential pathway involved in development and cancer. It controls the Gli code-the sum of all activator and repressor functions of the Gli transcription factors. Through the Gli code, and Gli1 in particul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::baf77ce19ff313855d9ac5b1d549fc28
https://pubmed.ncbi.nlm.nih.gov/22114144
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4
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code
Autor: Ruiz Altaba, Ariel, Nguyên, Vân, Palma, Veronica
Publikováno v: Current Opinion in Genetics & Development, Vol. 13, No 5 (2003) pp. 513-521
The Sonic hedgehog (Shh) pathway plays an important role in the development of many tissues and organs. The secreted ligand Shh has been shown to act as a mitogen, morphogen and survival factor in different contexts whereas the three Gli transcriptio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::8ea2771bf9242ae5df0c52c8ce211e3f
https://archive-ouverte.unige.ch/unige:154164
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5
Gli and hedgehog in cancer: tumours, embryos and stem cells
Autor: Ruiz Altaba, Ariel, Sánchez, Pilar, Dahmane, Nadia
Publikováno v: Nature Reviews Cancer, Vol. 2, No 5 (2002) pp. 361-372
Do tumours arise from stem cells, or are they derived from more differentiated cells that, for some reason, begin to recapitulate developmental programmes? Inappropriate activation of the Sonic hedgehog-Gli signalling pathway occurs in several types
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::35fa242b693098403158b130cd7eb180
https://archive-ouverte.unige.ch/unige:154168
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6
Hedgehog-Gli signalling and the growth of the brain
Autor: Ruiz Altaba, Ariel, Palma, Verónica, Dahmane, Nadia
Publikováno v: Nature Reviews Neuroscience, Vol. 3, No 1 (2002) pp. 24-33
The development of the vertebrate brain involves the creation of many cell types in precise locations and at precise times, followed by the formation of functional connections. To generate its cells in the correct numbers, the brain has to produce ma
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::d161da88f6d0d871ae090dc77737d6ce
https://archive-ouverte.unige.ch/unige:154169
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7
Embryonic regionalization of the neocortex
Autor: Ruiz Altaba, Ariel, Gitton, Y, Dahmane, N
Publikováno v: Mechanisms of Development, Vol. 107, No 1-2 (2001) pp. 3-11
Understanding the development of the vertebrate brain and in particular that of the neocortex, where high brain functions reside, remains one of the most difficult and exciting tasks in biology. In this review, we discuss recent experimental evidence
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::de3eefbf789c0e67292c48b85a4cbc8c
https://archive-ouverte.unige.ch/unige:154171
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9
Coexpression of HNF-3 beta and Isl-1/2 and mixed distribution of ventral cell types in the early neural tube
Autor: Ruiz Altaba, Ariel
Publikováno v: International Journal of Developmental Biology, Vol. 40, No 6 (1996) pp. 1081-1088
Pattern formation in the vertebrate ventral neural tube has been proposed to depend on the ability of notochord-derived signals to induce the differentiation of distinct cell types in a distance-dependent manner. To determine whether the distribution
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d1a972f4f63a9aaac0e69c4b17d5b10c
https://pubmed.ncbi.nlm.nih.gov/9032013
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10
Pattern formation in the vertebrate neural plate
Autor: Ruiz Altaba, Ariel
Publikováno v: Trends in Neurosciences, Vol. 17, No 6 (1994) pp. 233-243
Recent advances have been made in the understanding of the cellular and molecular mechanisms involved in the formation and patterning of the neural plate of vertebrate embryos. Both planar and vertical signaling pathways appear to be involved in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::93282120bbe9f5e7483a14441a1f57e5
https://archive-ouverte.unige.ch/unige:154199
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