Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ruixin Sun"'
Autor:
Jiaxing Liang, Tengchi Ma, Youlei Li, Ruixin Sun, Shuaishuai Zhao, Yuzhe Shen, Hui Gao, Yunhang Jing, Xinyue Bai, Mengze He, Qingyan Wang, Huilin Xi, Rui Shi, Yanling Yang
Publikováno v:
Heliyon, Vol 10, Iss 10, Pp e30699- (2024)
Background: Neurofilaments are neuron specific skeleton proteins maintaining axon transduction speed, leaked into cerebrospinal fluid and serum after axonal injury or neuron death. Sleep duration change has long related to many health issues but lack
Externí odkaz:
https://doaj.org/article/30f8800432594615859fad5448448118
Autor:
Yifan Liu, Yansha Sun, Peng Wang, Songling Li, Yiwei Dong, Min Zhou, Bizhi Shi, Hua Jiang, Ruixin Sun, Zonghai Li
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract Purpose The claudin 18.2 (CLDN18.2) antigen is frequently expressed in malignant tumors, including pancreatic ductal adenocarcinoma (PDAC). Although CLDN18.2-targeted CAR-T cells demonstrated some therapeutic efficacy in PDAC patients, furth
Externí odkaz:
https://doaj.org/article/5632fc3b3ee44b4581f2c8db46da73cd
Autor:
Yansha Sun, Yiwei Dong, Ruixin Sun, Yifan Liu, Yi Wang, Hong Luo, Bizhi Shi, Hua Jiang, Zonghai Li
Publikováno v:
Molecular Therapy: Oncolytics, Vol 25, Iss , Pp 160-173 (2022)
Chimeric antigen receptor (CAR) T cells targeting glypican-3 (GPC3) demonstrated early signs of therapeutic efficacy to hepatocellular carcinoma patients with a risk of cytokine release syndrome (CRS). Several adoptive cell therapies (ACTs) with T ce
Externí odkaz:
https://doaj.org/article/cf9ca9d3ef9b4f4d9976bf660510f421
Autor:
Hong Luo, Xiuqi Wu, Ruixin Sun, Jingwen Su, Yi Wang, Yiwei Dong, Bizhi Shi, Yansha Sun, Hua Jiang, Zonghai Li
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch) recept
Externí odkaz:
https://doaj.org/article/0a9398179cfa436fbfe038177d34ed5a
Autor:
Chuanlong Wu, Xuqiang Liu, Ruixin Sun, Yunhao Qin, Zhiqing Liu, Shengbing Yang, Tingting Tang, Zhenan Zhu, Degang Yu, Fengxiang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/9bc8d45e70e544dea448aa684752b6e7
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Incorporation of inverted cytokine receptor (ICR) such as interleukin (IL)-4 vs. IL-7 (4/7) ICR is one strategy to improve the antitumor activities of chimeric antigen receptor (CAR) modified T (CAR-T) cells facing immunosuppressive cytokines. Here w
Externí odkaz:
https://doaj.org/article/1375ea108da542feacb5a1582ea86159
Autor:
Muhua Chen, Ruixin Sun, Bizhi Shi, Yi Wang, Shengmeng Di, Hong Luo, Yansha Sun, Zonghai Li, Min Zhou, Hua Jiang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 113, Iss , Pp - (2019)
Chimeric antigen receptor (CAR) T cell therapy has shown remarkable success in hematological tumors. However, many challenges remain in improving the efficacy of CAR T cells in solid tumors. The epidermal growth factor receptor variant III (EGFRvIII)
Externí odkaz:
https://doaj.org/article/f28cf70ccb694b8b93bdafcbc55aa832
Autor:
Shengmeng Di, Min Zhou, Zeyan Pan, Ruixin Sun, Muhua Chen, Hua Jiang, Bizhi Shi, Hong Luo, Zonghai Li
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Chimeric antigen receptor modified T cells (CAR-T) therapy is an emerging immunotherapy against malignancies. However, only limited success was obtained in solid tumors. Polyinosinic-polycytidylic acid (poly I:C), ligand of TLR3, mediates innate immu
Externí odkaz:
https://doaj.org/article/f016762c5f3c46be8208de6b577b9d7c
Autor:
Chuanlong Wu, Xuqiang Liu, Ruixin Sun, Yunhao Qin, Zhiqing Liu, Shengbing Yang, Tingting Tang, Zhenan Zhu, Degang Yu, Fengxiang Liu
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Joint replacement is essential for the treatment of serious joint disease. However, prosthetic failure remains an important clinical issue, with periprosthesis osteolysis (PO), caused by osteoclastic bone resorption induced by wear particles, being t
Externí odkaz:
https://doaj.org/article/19ed46c2a8fc4de9a1d5aeab37530aec
Autor:
Xingliang Guo, Hua Jiang, Bizhi Shi, Min Zhou, Honghong Zhang, Zhimin Shi, Guoxiu Du, Hong Luo, Xiuqi Wu, Yi Wang, Ruixin Sun, Zonghai Li
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Cancer immunotherapy has made unprecedented breakthrough in the fields of chimeric antigen receptor-redirected T (CAR T) cell therapy and immune modulation. Combination of CAR modification and the disruption of endogenous inhibitory immune checkpoint
Externí odkaz:
https://doaj.org/article/9df19ee0d8f742d4a4fe8390aaa1faf1