Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming

Autor: Li Tan, Zhonghe Ke, Gregory Tombline, Nicholas Macoretta, Kevin Hayes, Xiao Tian, Ruitu Lv, Julia Ablaeva, Michael Gilbert, Natarajan V. Bhanu, Zuo-Fei Yuan, Benjamin A. Garcia, Yujiang G. Shi, Yang Shi, Andrei Seluanov, Vera Gorbunova

Publikováno v: Stem Cell Reports, Vol 9, Iss 5, Pp 1721-1734 (2017)

Summary: Naked mole rat (NMR) is a valuable model for aging and cancer research due to its exceptional longevity and cancer resistance. We observed that the reprogramming efficiency of NMR fibroblasts in response to OSKM was drastically lower than th

Externí odkaz: https://doaj.org/article/555f64213cd742b0b9d42f0735085c92

Genome-Wide Mapping of 5mC and 5hmC Identified Differentially Modified Genomic Regions in Late-Onset Severe Preeclampsia: A Pilot Study.

Autor: Lisha Zhu, Ruitu Lv, Lingchun Kong, Haidong Cheng, Fei Lan, Xiaotian Li

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0134119 (2015)

Preeclampsia (PE) is a leading cause of perinatal morbidity and mortality. However, as a common form of PE, the etiology of late-onset PE is elusive. We analyzed 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) levels in the placentas of lat

Externí odkaz: https://doaj.org/article/ca4a6e8a5d6846b5a7ba89ddacfea987

The histone methyltransferase SETD2 is required for expression of acrosin-binding protein 1 and protamines and essential for spermiogenesis in mice

Autor: Li Li, Xiaoli Zuo, Bowen Rong, Fei Lan, Ming-Han Tong, Ruitu Lv

Publikováno v: Journal of Biological Chemistry. 293:9188-9197

Spermatogenesis is precisely controlled by complex gene expression programs and involves epigenetic reprogramming, including histone modification and DNA methylation. SET domain–containing 2 (SETD2) is the predominant histone methyltransferase cata

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bb32eb66661f4704c53f9cddedb86e
https://doi.org/10.1074/jbc.ra118.002851

HNF1B-mediated repression of SLUG is suppressed by EZH2 in aggressive prostate cancer

Autor: Chenxi He, Huihui Zhou, Jianqing Wang, Ke Zhang, Ruitu Lv, Caibin Fan, Qidong Zhou, Siqing Wang, Jian Sun, Guanxiong Ding, Fei Lan, Peng Gao

Publikováno v: Oncogene

Prostate cancer is the most common malignancy in men in developed countries. Overexpression of enhancer of zeste homolog 2 (EZH2), the major histone H3 lysine 27 methyltransferase, has been connected to prostate cancer malignancy. However, its downst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f85fc77477cff886f3ebef167ee9a8
https://pubmed.ncbi.nlm.nih.gov/31636385

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Autor: Yang Shi, Jia Fan, Jia-Bin Cai, Kai Chen, Yujiang Geno Shi, Tao Pan, Honghui Ma, Xiaoyun Wang, Zhike Lu, Bruno P. Klaholz, Fei Lan, Hao Chen, Chuan He, S. Kundhavai Natchiar, Ruitu Lv, Qing Dai

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2019, 15 (1), pp.88-94. ⟨10.1038/s41589-018-0184-3⟩
Nature Chemical Biology, 2019, 15 (1), pp.88-94. ⟨10.1038/s41589-018-0184-3⟩

International audience; N6-Methyladenosine (m6A) RNA modification is present in messenger RNAs (mRNA), ribosomal RNAs (rRNA), and spliceosomal RNAs (snRNA) in humans. Although mRNA m6A modifications have been extensively studied and shown to play cri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb2a954501d90b20961326e60a31dee
https://www.hal.inserm.fr/inserm-02409786