Innovative strategies for measuring kinase activity to accelerate the next wave of novel kinase inhibitors

Autor: Veth, Tim S., Kannegieter, Nynke M., de Graaf, Erik L., Ruijtenbeek, Rob, Joore, Jos, Ressa, Anna, Altelaar, Maarten

Publikováno v: In Drug Discovery Today March 2024 29(3)

Esterified derivatives of DHA and EPA increase bortezomib cytotoxicity in human multiple myeloma cells

Autor: Chen, Jing, Ruijtenbeek, Rob, Garssen, Johan, Redegeld, Frank A.

Publikováno v: In European Journal of Pharmacology 5 May 2022 922

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Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib

Autor: Diekstra, Meta HM, Swen, Jesse J, Van Der Zanden, Loes FM, Vermeulen, Sita H, Boven, Epie, Mathijssen, Ron HJ, Fukunaga, Koya, Mushiroda, Taisei, Hongo, Fumiya, Oosterwijk, Egbert, Cambon-Thomsen, Anne, Castellano, Daniel, Fritsch, Achim, Donas, Jesus Garcia, Rodriguez-Antona, Cristina, Ruijtenbeek, Rob, Radu, Marius T, Eisen, Tim, Junker, Kerstin, Roessler, Max, Jaehde, Ulrich, Miki, Tsuneharu, Böhringer, Stefan, Kubo, Michiaki, Kiemeney, Lambertus ALM, Guchelaar, Henk-Jan

Publikováno v: Cancers, 14(12):2838. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, 14
Cancers; Volume 14; Issue 12; Pages: 2838
Diekstra, M H M, Swen, J J, van der Zanden, L F M, Vermeulen, S H, Boven, E, Mathijssen, R H J, Fukunaga, K, Mushiroda, T, Hongo, F, Oosterwijk, E, Cambon-Thomsen, A, Castellano, D, Fritsch, A, Donas, J G, Rodriguez-Antona, C, Ruijtenbeek, R, Radu, M T, Eisen, T, Junker, K, Roessler, M, Jaehde, U, Miki, T, Böhringer, S, Kubo, M, Kiemeney, L A L M & Guchelaar, H-J 2022, ' Genome-Wide Meta-Analysis Identifies Variants in DSCAM and PDLIM3 That Correlate with Efficacy Outcomes in Metastatic Renal Cell Carcinoma Patients Treated with Sunitinib ', Cancers, vol. 14, no. 12, 2838 . https://doi.org/10.3390/cancers14122838
Cancers, 14, 12
Cancers, 14(12). MDPI

Contains fulltext : 251723.pdf (Publisher’s version ) (Open Access) Individual response to sunitinib in metastatic renal cell carcinoma (mRCC) patients is highly variable. Earlier, sunitinib outcome was related to single nucleotide polymorphisms (S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb9208a069dc8f7ed5a030818380125
https://pure.eur.nl/en/publications/cccc1405-5fd8-44d6-86c5-01ccfa346d2c

C‐Terminal Tag Location Hampers in Vitro Profiling of OGT Peptide Substrates by mRNA Display

Autor: Shi, Jie, Sharif, Suhela, Balsollier, Cyril, Ruijtenbeek, Rob, Pieters, Roland J., Jongkees, Seino A.K., Afd Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery

Publikováno v: Chembiochem
ChemBioChem, 22(4), 666. Wiley-VCH Verlag

O‐GlcNAc transferase (OGT) is the only enzyme that catalyzes the post‐translational modification of proteins at Ser/Thr with a single β‐N‐acetylglucosamine (O‐GlcNAcylation). Its activity has been associated with chronic diseases such as c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ae442166e8e41af3122d2aac2c1fef
http://europepmc.org/articles/PMC7894566