The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis.

Autor: Skov M; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Ruijs TQ; Centre for Human Drug Research, 2333 CL Leiden, Netherlands.; Leiden University Medical Centre, 2333 ZA Leiden, Netherlands., Grønnebæk TS; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Skals M; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Riisager A; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Winther JB; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Dybdahl KLT; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Findsen A; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Morgen JJ; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Huus N; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Broch-Lips M; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Nielsen OB; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Ole Worms Alle 4, 8000 Aarhus C, Denmark., de Cuba CMKE; Centre for Human Drug Research, 2333 CL Leiden, Netherlands.; Leiden University Medical Centre, 2333 ZA Leiden, Netherlands., Heuberger JAAC; Centre for Human Drug Research, 2333 CL Leiden, Netherlands., de Kam ML; Centre for Human Drug Research, 2333 CL Leiden, Netherlands., Tannemaat M; Leiden University Medical Centre, 2333 ZA Leiden, Netherlands., Verschuuren JJGM; Leiden University Medical Centre, 2333 ZA Leiden, Netherlands., Knutsen LJS; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Kelly NM; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Jensen KG; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Arnold WD; NextGen Precision Health, University of Missouri, 1030 Hitt St, Columbia, MO 65212, USA., Burghes AH; Department of Biological Chemistry and Pharmacology, Ohio State University Wexner Medical Center, 1060 Carmack Road, Columbus, OH 43210, USA.; Department of Neurology, Neuromuscular Division, Ohio State University Wexner Medical Center, 395 W. 12(th) Ave, Columbus, OH 43210, USA., Olesen C; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Ole Worms Alle 4, 8000 Aarhus C, Denmark., Bold J; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Petersen TK; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Quiroz JA; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Hutchison J; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Chin ER; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark., Groeneveld GJ; Centre for Human Drug Research, 2333 CL Leiden, Netherlands.; Leiden University Medical Centre, 2333 ZA Leiden, Netherlands., Pedersen TH; NMD Pharma A/S, Palle Juul-Jensens Boulevard 82, 8200 Aarhus N, Denmark.; Department of Biomedicine, Aarhus University, Ole Worms Alle 4, 8000 Aarhus C, Denmark.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Mar 20; Vol. 16 (739), pp. eadk9109. Date of Electronic Publication: 2024 Mar 20.

Effects of Mexiletine and Lacosamide on Nerve Excitability in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study.

Autor: Ruijs TQ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Koopmans IW; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., de Kam ML; Centre for Human Drug Research, Leiden, The Netherlands., van Esdonk MJ; Centre for Human Drug Research, Leiden, The Netherlands., Koltzenburg M; National Hospital for Neurology and Neurosurgery, London, UK., Groeneveld GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Centre, Leiden, The Netherlands., Heuberger JAAC; Centre for Human Drug Research, Leiden, The Netherlands.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Nov; Vol. 112 (5), pp. 1008-1019. Date of Electronic Publication: 2022 Jul 19.

Transcranial magnetic stimulation as a translational biomarker for AMPA receptor modulation.

Autor: O'Donnell P; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA. Patricio.odonnell@takeda.com.; McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA. Patricio.odonnell@takeda.com., Dijkstra FM; Centre for Human Drug Research (CHDR), Leiden, The Netherlands.; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Damar U; Neuromodulation Program, Department of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Quanhong L; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., de Goede AA; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Xu L; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., Pascual-Leone A; Neuromodulation Program, Department of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Buhl DL; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., Zuiker R; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Ruijs TQ; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., Heuberger JAAC; Centre for Human Drug Research (CHDR), Leiden, The Netherlands., MacMullin P; Neuromodulation Program, Department of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Lubell M; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., Asgharnejad M; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., Murthy V; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA., Rotenberg A; Neuromodulation Program, Department of Neurology and F.M. Kirby Center for Neurobiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Jacobs GE; Centre for Human Drug Research (CHDR), Leiden, The Netherlands.; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands., Rosen L; Takeda Pharmaceuticals International, Inc., Cambridge, MA, USA.

Publikováno v: Translational psychiatry [Transl Psychiatry] 2021 May 27; Vol. 11 (1), pp. 325. Date of Electronic Publication: 2021 May 27.