Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ruijie K. Zhang"'
Publikováno v:
ACS Central Science, Vol 1, Iss 2, Pp 89-93 (2015)
Externí odkaz:
https://doaj.org/article/916a75cfe6e84b9684eaee992cf698d4
Autor:
Ryan M. Phelan, Michael J. Abrahamson, Jesse T. C. Brown, Ruijie K. Zhang, Christian R. Zwick
Publikováno v:
Organic Process Research & Development. 26:1944-1959
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c800739f89685c97952a7084acd46048
https://doi.org/10.1021/acs.oprd.1c00467
https://doi.org/10.1021/acs.oprd.1c00467
Publikováno v:
Nature. 565:67-72
Although abundant in organic molecules, carbon–hydrogen (C–H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent advances in C–H functionalization technology have begun to transform this logic, while emp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30f9a3559d0c25439dd925d6cb753257
https://doi.org/10.1038/s41586-018-0808-5
https://doi.org/10.1038/s41586-018-0808-5
Publikováno v:
J Am Chem Soc
Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that Pseudomonas savastanoi ethylene-forming enzyme (PsEFE), a non-heme iron enzyme, can catalyze olefin aziridination and nitrene C–H insertion, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb1aba006212962763f16a8834ee47f
https://resolver.caltech.edu/CaltechAUTHORS:20191125-092520827
https://resolver.caltech.edu/CaltechAUTHORS:20191125-092520827
Selective C-H bond functionalization with engineered heme proteins: new tools to generate complexity
C—H functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of C—H oxidations in biology. Recent work has coupled concepts from synthetic chemis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5760156f26b6c761e207fe390bfa1ae
https://resolver.caltech.edu/CaltechAUTHORS:20181029-094838266
https://resolver.caltech.edu/CaltechAUTHORS:20181029-094838266
Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unpro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4045db16d52904dd5e9c79fccedc91ec
https://resolver.caltech.edu/CaltechAUTHORS:20190102-135256908
https://resolver.caltech.edu/CaltechAUTHORS:20190102-135256908
Autor:
Ruijie K, Zhang, Kai, Chen, Xiongyi, Huang, Lena, Wohlschlager, Hans, Renata, Frances H, Arnold
Publikováno v:
Nature
Although abundant in organic molecules, carbon-hydrogen (C-H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent advances in C-H functionalization technology have begun to transform this logic, while emphasizi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a13fcbfe233fdacc82095d32315f230
https://pubmed.ncbi.nlm.nih.gov/30568304
https://pubmed.ncbi.nlm.nih.gov/30568304
Double rings made with heme Cyclic organic structures with adjacent three-carbon rings—bicyclobutanes—are useful starting materials for chemical and materials synthesis owing to their extreme ring strain. Constructing these molecules is a challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cc5c15e511e46b39923a15c148ed72
https://resolver.caltech.edu/CaltechAUTHORS:20180405-130352978
https://resolver.caltech.edu/CaltechAUTHORS:20180405-130352978
Publikováno v:
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis ISBN: 9783527804085
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Artificial Metalloenzymes and MetalloDNAzymes in Catalysis
Directed evolution is a powerful algorithm for engineering proteins to have novel and useful properties. However, we do not yet fully understand the characteristics of an evolvable system. In this chapter, we present examples where directed evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc95a4efd23109dec635aa3e5b9a0121
https://doi.org/10.1002/9783527804085.ch5
https://doi.org/10.1002/9783527804085.ch5
Publikováno v:
ACS Central Science
ACS Central Science, Vol 1, Iss 2, Pp 89-93 (2015)
ACS Central Science, Vol 1, Iss 2, Pp 89-93 (2015)
One of the greatest challenges in protein design is creating new enzymes, something evolution does all the time, starting from existing ones. Borrowing from nature’s evolutionary strategy, we have engineered a bacterial cytochrome P450 to catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe1c49dafb54c32735c499c4432b62d
https://doi.org/10.1021/acscentsci.5b00056
https://doi.org/10.1021/acscentsci.5b00056