Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ruidong, Xiang"'
Autor:
Mohammad Ghoreishifar, Amanda J. Chamberlain, Ruidong Xiang, Claire P. Prowse-Wilkins, Thomas J. Lopdell, Mathew D. Littlejohn, Jennie E. Pryce, Michael E. Goddard
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-11 (2024)
Abstract Background Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as those marked by certain histone modifications. These variants are believed to influence gen
Externí odkaz:
https://doaj.org/article/909bbb2cefc147078721ba74bc8405dd
Autor:
Irene van den Berg, Amanda J. Chamberlain, Iona M. MacLeod, Tuan V. Nguyen, Mike E. Goddard, Ruidong Xiang, Brett Mason, Susanne Meier, Claire V. C. Phyn, Chris R. Burke, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Female fertility is an important trait in dairy cattle. Identifying putative causal variants associated with fertility may help to improve the accuracy of genomic prediction of fertility. Combining expression data (eQTL) of genes,
Externí odkaz:
https://doaj.org/article/eb916b93e29a4197bc37af791abba3ff
Publikováno v:
Evolutionary Applications, Vol 17, Iss 6, Pp n/a-n/a (2024)
Abstract As an invaluable Chinese sheep germplasm resource, Hu sheep are renowned for their high fertility and beautiful wavy lambskins. Their distinctive characteristics have evolved over time through a combination of artificial and natural selectio
Externí odkaz:
https://doaj.org/article/182c300d3bfe4631ae235ebcecae337b
Autor:
Ruidong Xiang, Martin Kelemen, Yu Xu, Laura W. Harris, Helen Parkinson, Michael Inouye, Samuel A. Lambert
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Polygenic scores (PGS) can be used for risk stratification by quantifying individuals’ genetic predisposition to disease, and many potentially clinically useful applications have been proposed. Here, we review the latest potential benefits
Externí odkaz:
https://doaj.org/article/afd2a65ad1024f02a94ecb4905c69f5e
Autor:
Monica Kanki, Artika P. Nath, Ruidong Xiang, Stephanie Yiallourou, Peter J. Fuller, Timothy J. Cole, Rodrigo Cánovas, Morag J. Young
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Disrupted circadian rhythms have been linked to an increased risk of hypertension and cardiovascular disease. However, many studies show inconsistent findings and are not sufficiently powered for targeted subgroup analyses. Using the UK Biob
Externí odkaz:
https://doaj.org/article/e6d31206a7c94d4d87347ab8e8d4bf47
Autor:
Consuelo Amor S. Estrella, Kathryn L. Gatford, Ruidong Xiang, Ali Javadmanesh, Mani Ghanipoor-Samami, Greg S. Nattrass, Entesar Shuaib, Milton M. McAllister, Ian Beckman, Dana A. Thomsen, Vicki L. Clifton, Julie A. Owens, Claire T. Roberts, Stefan Hiendleder, Karen L. Kind
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2024)
IntroductionSex differences in prenatal growth may contribute to sex-dependent programming effects on postnatal phenotype. MethodsWe integrated for the first time phenotypic, histomorphological, clinico-chemical, endocrine and gene expression analyse
Externí odkaz:
https://doaj.org/article/1ba89041b5af490ead28df8a7c01ae87
Autor:
Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100385- (2023)
Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) o
Externí odkaz:
https://doaj.org/article/97272e77d4a5469f8c556d16c5b5034e
Autor:
Tuan V. Nguyen, Christy J. Vander Jagt, Jianghui Wang, Hans D. Daetwyler, Ruidong Xiang, Michael E. Goddard, Loan T. Nguyen, Elizabeth M. Ross, Ben J. Hayes, Amanda J. Chamberlain, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-15 (2023)
Abstract Studies have demonstrated that structural variants (SV) play a substantial role in the evolution of species and have an impact on Mendelian traits in the genome. However, unlike small variants (
Externí odkaz:
https://doaj.org/article/659b18ddcf7241ca859ede196b0ba0f0
Autor:
Claire P. Prowse-Wilkins, Thomas J. Lopdell, Ruidong Xiang, Christy J. Vander Jagt, Mathew D. Littlejohn, Amanda J. Chamberlain, Michael E. Goddard
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background Causal variants for complex traits, such as eQTL are often found in non-coding regions of the genome, where they are hypothesised to influence phenotypes by regulating gene expression. Many regulatory regions are marked by histone
Externí odkaz:
https://doaj.org/article/bc8d9d89f6eb439bb8e78fb640312239
Publikováno v:
Frontiers in Animal Science, Vol 4 (2023)
Selection decisions are generally based on estimated breeding values (EBV) for a combination of traits that are polygenic (e.g. milk production). However, in some cases, there is additional intense selection for a single allele, or SNP, for a perceiv
Externí odkaz:
https://doaj.org/article/ec1c49fc7a0e44768f9cbdbc87ca1a8e