Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Ruibo, Wu"'
Publikováno v:
JACS Au, Vol 4, Iss 7, Pp 2492-2502 (2024)
Externí odkaz:
https://doaj.org/article/3245f8d9092f45d491530e5f6accf0f1
Publikováno v:
Pharmaceutical Science Advances, Vol 2, Iss , Pp 100054- (2024)
Externí odkaz:
https://doaj.org/article/fcd442c9fa53489388d54f82471d87b6
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The synthesis of allenyl boronates is an important yet challenging topic in organic synthesis. Reported herein is an NHC‐gold‐catalyzed 1,3‐H shift toward allenyl boronates synthesis from simple propargylic B(MIDA)s. Mechanistic studie
Externí odkaz:
https://doaj.org/article/f7dba9e03f834b3ba99b0ed130b29b11
Autor:
Zhong Li, Lilan Zhang, Kangwei Xu, Yuanyuan Jiang, Jieke Du, Xingwang Zhang, Ling-Hong Meng, Qile Wu, Lei Du, Xiaoju Li, Yuechan Hu, Zhenzhen Xie, Xukai Jiang, Ya-Jie Tang, Ruibo Wu, Rey-Ting Guo, Shengying Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Diterpene synthase VenA is responsible for assembling venezuelaene A with a unique 5-5-6-7 tetracyclic skeleton from geranylgeranyl pyrophosphate. VenA also demonstrates substrate promiscuity by accepting geranyl pyrophosphate and farnesyl p
Externí odkaz:
https://doaj.org/article/edd63d160b41477f8f37ff2ed99ab384
Publikováno v:
Molecules, Vol 29, Iss 8, p 1867 (2024)
Natural products (NPs) have diverse biological activity and significant medicinal value. The structural diversity of NPs is the mainstay of drug discovery. Expanding the chemical space of NPs is an urgent need. Inspired by the concept of fragment-ass
Externí odkaz:
https://doaj.org/article/933ffc73df2b4f86a21ff4dbf65310ff
Autor:
Yunjun Pan, Guobang Li, Ruxin Liu, Jiawei Guo, Yunjie Liu, Mingyu Liu, Xingwang Zhang, Luping Chi, Kangwei Xu, Ruibo Wu, Yuzhong Zhang, Yuezhong Li, Xiang Gao, Shengying Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The 20 proteinogenic amino acids cannot always satisfy the requirements of protein engineering. Here, the authors practice semi-rational non-canonical amino acid mutagenesis for a cytochrome P450 enzyme, leading to unnatural activities and significan
Externí odkaz:
https://doaj.org/article/506ff1a116c343bdb4d427ee37445c79
Autor:
Chuwei Liu, Arabella H. Wan, Heng Liang, Lei Sun, Jiarui Li, Ranran Yang, Qinghai Li, Ruibo Wu, Kunhua Hu, Yuedong Yang, Shirong Cai, Guohui Wan, Weiling He
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 4540-4551 (2023)
Tumor mutation burden (TMB) has emerged as an essential biomarker for assessing the efficacy of cancer immunotherapy. However, due to the inherent complexity of tumors, TMB is not always correlated with the responsiveness of immune checkpoint inhibit
Externí odkaz:
https://doaj.org/article/c98c0952daaa4ce08c6716815fd5db9d
Autor:
Shuangjia Zheng, Tao Zeng, Chengtao Li, Binghong Chen, Connor W. Coley, Yuedong Yang, Ruibo Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The complete biosynthetic pathway from most natural products (NPs) are unknown. Here, the authors report BioNavi-NP, a computational toolkit for bio-retrosynthetic pathway elucidation or reconstruction for both NPs and NP-like compounds.
Externí odkaz:
https://doaj.org/article/827dd85e0c6944e990ba1c7ab32d1d53
Autor:
Wenlong Zha, Fan Zhang, Jiaqi Shao, Xingmei Ma, Jianxun Zhu, Pinghua Sun, Ruibo Wu, Jiachen Zi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Controlling the component ratios of plant essential oils is challenging in their heterologous bioproduction. Here, the authors combine metabolic and enzymatic engineering strategies to achieve the production of sandalwood oil with a desirable compone
Externí odkaz:
https://doaj.org/article/163fe29074a443c4b5ffd56d1ecd1652
Publikováno v:
Clinical Laboratory; 2024, Vol. 70 Issue 11, p2063-2070, 8p