Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Ruibin, Xi"'
Autor:
Dong-Jin Han, Sunmin Kim, Seo-Young Lee, Youngbeen Moon, Su Jung Kang, Jinseon Yoo, Hye Young Jeong, Hae Jin Cho, Jeong Yang Jeon, Byeong Chang Sim, Jaehoon Kim, Seungho Lee, Ruibin Xi, Tae-Min Kim
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Determining the impact of somatic mutations requires understanding the functional relationship of genes acquiring mutations; however, it is largely unknown how mutations in functionally related genes influence each other. Methods
Externí odkaz:
https://doaj.org/article/f2bc79ae35be430a9afb4d75ad0ce6bf
Autor:
Dongning Rao, Jiaxin Li, Mao Zhang, Siyuan Huang, Lu Meng, Guohe Song, Jiaqiang Ma, Yingcheng Wu, Yifei Cheng, Shuyi Ji, Gaohua Wu, Lv Chen, Yuming Liu, Yang Shi, Jian Zhou, Fan Jia, Xiaoming Zhang, Ruibin Xi, Qiang Gao
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Gallbladder cancer (GBC) is the most common and lethal malignancy of the biliary tract that lacks effective therapy. In many GBC cases, infiltration into adjacent organs or distant metastasis happened long before the diagnosis, es
Externí odkaz:
https://doaj.org/article/56b923b3915241cfaaee43ede419f5ad
Publikováno v:
Cell Reports: Methods, Vol 4, Iss 7, Pp 100810- (2024)
Summary: In single-cell RNA sequencing (scRNA-seq) studies, cell types and their marker genes are often identified by clustering and differentially expressed gene (DEG) analysis. A common practice is to select genes using surrogate criteria such as v
Externí odkaz:
https://doaj.org/article/9c98a4c4e88d421a8008ba293e5a7534
Autor:
Zijie Xu, Siyuan Huang, Yifan Song, Chao Xu, Hongyu Yan, Ouyang Linkun, Bo Lv, Fuzhen Yuan, Bingbing Xu, Haijun Wang, Ruibin Xi, Jia-Kuo Yu
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109697- (2024)
Summary: The inheritance of recurrent patellar dislocation (RPD) is known, but the susceptible gene remains unidentified. Here, we performed the first whole exome sequencing (WES) cohort study to identify the susceptible genes. The results showed eig
Externí odkaz:
https://doaj.org/article/5c2f820abd8246d784c0e4a3078a669a
Autor:
Tianyun Zhang, Hanying Jia, Tairan Song, Lin Lv, Doga C. Gulhan, Haishuai Wang, Wei Guo, Ruibin Xi, Hongshan Guo, Ning Shen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Identifying expressed somatic mutations from single-cell RNA sequencing data de novo is challenging but highly valuable. We propose RESA – Recurrently Expressed SNV Analysis, a computational framework to identify expressed somatic mutation
Externí odkaz:
https://doaj.org/article/ad06594af069403b885f96af7a6cbad2
Autor:
Yuchao Xia, Zijie Jin, Chengsheng Zhang, Linkun Ouyang, Yuhao Dong, Juan Li, Lvze Guo, Biyang Jing, Yang Shi, Susheng Miao, Ruibin Xi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Single-molecule Real-time Isoform Sequencing (Iso-seq) of transcriptomes by PacBio can generate very long and accurate reads, thus providing an ideal platform for full-length transcriptome analysis. We present an integrated computational too
Externí odkaz:
https://doaj.org/article/b2b5f4d3b91d40688dae21b0a8b02864
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract Background Neoantigens are critical for anti-tumor immunity and have been long-envisioned as promising therapeutic targets. However, current neoantigen analyses mostly focus on single nucleotide variations (SNVs) and indel mutations and seld
Externí odkaz:
https://doaj.org/article/b853ef7e03ba4267ae89db9c43a34f8d
Autor:
Guohe Song, Yang Shi, Lu Meng, Jiaqiang Ma, Siyuan Huang, Juan Zhang, Yingcheng Wu, Jiaxin Li, Youpei Lin, Shuaixi Yang, Dongning Rao, Yifei Cheng, Jian Lin, Shuyi Ji, Yuming Liu, Shan Jiang, Xiaoliang Wang, Shu Zhang, Aiwu Ke, Xiaoying Wang, Ya Cao, Yuan Ji, Jian Zhou, Jia Fan, Xiaoming Zhang, Ruibin Xi, Qiang Gao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The molecular classification and tumour microenvironment in intrahepatic cholangiocarcinoma (iCCA) need further characterisation. Here, the authors perform single cell RNA-sequencing from 14 pairs of iCCA tumours and non-tumour liver tissues and prop
Externí odkaz:
https://doaj.org/article/d1872e649e1344dba5a7cc26ee3c1275
Autor:
Zijie Jin, Wenjian Huang, Ning Shen, Juan Li, Xiaochen Wang, Jiqiao Dong, Peter J. Park, Ruibin Xi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Gene fusions are an important class of mutations in tumor genomes. Here, the authors develop a single-cell gene fusion detection method scFusion and demonstrate its applications in cancer single-cell studies.
Externí odkaz:
https://doaj.org/article/7aa3f7c6ef974ef386e0c2edf0651096
Autor:
Guohe Song, Yang Shi, Meiying Zhang, Shyamal Goswami, Saifullah Afridi, Lu Meng, Jiaqiang Ma, Yi Chen, Youpei Lin, Juan Zhang, Yuming Liu, Zijie Jin, Shuaixi Yang, Dongning Rao, Shu Zhang, Aiwu Ke, Xiaoying Wang, Ya Cao, Jian Zhou, Jia Fan, Xiaoming Zhang, Ruibin Xi, Qiang Gao
Publikováno v:
Cell Discovery, Vol 6, Iss 1, Pp 1-15 (2020)
Abstract Diverse immune cells in the tumor microenvironment form a complex ecosystem, but our knowledge of their heterogeneity and dynamics within hepatocellular carcinoma (HCC) still remains limited. To assess the plasticity and phenotypes of immune
Externí odkaz:
https://doaj.org/article/c5a666494abc4fdc99a5041b4b14afe1