Zobrazeno 1 - 10 of 28 pro vyhledávání: '"RuiJuan Yin"'
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Akademický článek
Protective Effects of Marine Alkaloid Neolamellarin A Derivatives against Glutamate Induced PC12 Cell Apoptosis
Autor: Kai Zhang, Xian Guan, Xiao Zhang, Lu Liu, Ruijuan Yin, Tao Jiang
Publikováno v: Marine Drugs, Vol 20, Iss 4, p 262 (2022)
Marine alkaloids obtained from sponges possess a variety of biological activities and potential medicinal value. The pyrrole-derived lamellarin-like alkaloids, especially their permethyl derivatives, show low cytotoxicity and potent MDR reversing act
Externí odkaz: https://doaj.org/article/98a7c34819a642c8bed46d69fe95787f
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4
Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo
Autor: Guorui Zhang, Ruijuan Yin, Xiufei Dai, Guanzhao Wu, Xin Qi, Rilei Yu, Jing Li, Tao Jiang
Publikováno v: European journal of medicinal chemistry. 241
A series of novel 7-substituted 10,11-methylenedioxy-camptothecin (FL118) derivatives were designed, synthesized, and biologically evaluated. All the FL118 analogues showed significant cytotoxic activities in vitro with IC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643b009d2561911f8031099abebe0e1a
https://pubmed.ncbi.nlm.nih.gov/35932565
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6
Design, Synthesis and Structure-activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors
Autor: JianQiang Zhang, Rui Li, XueYang Dong, Na He, RuiJuan Yin, MengKe Yang, JieYu Liu, RiLei Yu, ChenYang Zhao, Tao Jiang
Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 2199
Hyperactivation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling is an attractive therapeutic target for tumor therapy. Herein, forty-eight novel meridianin derivatives were designed and synthesized, and thei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b888441471123ef743c17fd89b15b7b
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7
Design, Synthesis, and In Vitro/In Vivo Anti-Cancer Activities of Novel (20S)-10,11-Methylenedioxy-Camptothecin Heterocyclic Derivatives
Autor: Ruijuan Yin, Xiaomin Zhang, Guanzhao Wu, Qi Xin, Tao Jiang, Jing Li, Yixuan Zhang, Xiufen Dai
Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences, Vol 21, Iss 8495, p 8495 (2020)
A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6234365dc09995a18b42bb80c7fa738c
http://europepmc.org/articles/PMC7697887
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8
Synthesis and Neuroprotective Activity of Neolamellarin A Analogues
Autor: Yiran Zhang, Lijuan Zhang, Meng Zhang, Tao Jiang, Ruijuan Yin, Cui Hao
Publikováno v: Journal of Ocean University of China. 17:967-972
Alkaloids are a class of natural products with a wide range of biological activities. Due to the special living environment, the alkaloids from marine sponges have exhibited different biological activities and promising medical application potential.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79ba4779fdf73b86d842ddf680e3d695
https://doi.org/10.1007/s11802-018-3530-x
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9
Self-assembling nanoparticles of dually hydrophobic prodrugs constructed from camptothecin analogue for cancer therapy
Autor: Xueting Wang, Rilei Yu, Yixuan Zhang, Guanzhao Wu, Tao Jiang, Ruijuan Yin, Mingming Yu, Xuemeng Liu, Jiannan Liu, Hua-Shi Guan
Publikováno v: European journal of medicinal chemistry. 200
Nanomedicines have shown success in cancer therapy in recent years because of their excellent solubility in aqueous solution and drug accumulation through controlled release in tumor tissues, but the preparation of most nanomedicines still requires i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3598c5b7832957bc3c46b698f02832
https://pubmed.ncbi.nlm.nih.gov/32460113
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10
Guanidine modifications enhance the anti-herpes simplex virus activity of (E,E)-4,6-bis(styryl)-pyrimidine derivatives in vitro and in vivo
Autor: Wenmiao Li, Jinpeng Wang, Dongping Wang, Rilei Yu, Tao Jiang, Ruijuan Yin, Jianqiang Zhang, Cuijing Xu, Wei Wang
Publikováno v: Br J Pharmacol
Background and purpose The worldwide prevalence of herpes simplex virus (HSV) and shortage of efficient therapeutic strategies to counteract it are global concerns. In terms of treatment, the widely utilized anti-HSV drugs such as acyclovir have seri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0a65521d31cd67c5734a0b0d415959
https://pubmed.ncbi.nlm.nih.gov/31709511
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