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A small molecule inhibitor of caspase-1 inhibits NLRP3 inflammasome activation and pyroptosis to alleviate gouty inflammation

Autor: Dong-yi Cao, Zhong-hui Zhang, Run-ze Li, Xiao-ke Shi, Rui-ying Xi, Guo-lin Zhang, Fu Li, Fei Wang

Publikováno v: Immunology letters. 244

Caspase-1 is an integral regulator of innate immunity, which plays a key role in inflammasome activation and the release of pro-inflammatory cytokines. The development of novel non-peptidic small molecule caspase-1 inhibitors is an important strategy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ccde7eefbe1969ab452ac3d4f70d634
https://pubmed.ncbi.nlm.nih.gov/35288207

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Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways

Autor: Nai-jie Fu, Rui-ying Xi, Xiao-ke Shi, Run-ze Li, Zhong-hui Zhang, Ling-yu Li, Guo-lin Zhang, Fei Wang

Publikováno v: Toxicology and applied pharmacology. 441

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations account for 35% of the genetic alterations in non-small cell lung cancer (NSCLC). The Src-homology region 2-containing protein tyrosine phosphatase 2 (SHP2), encoded by PTPN11, is closely in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6471415569d436cc23c21ea5b02d6b3e
https://pubmed.ncbi.nlm.nih.gov/35307375

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