Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Rui-tian Liu"'
Autor:
Ling-Jie Li, Xiao-Ying Sun, Ya-Ru Huang, Shuai Lu, Yu-Ming Xu, Jing Yang, Xi-Xiu Xie, Jie Zhu, Xiao-Yun Niu, Dan Wang, Shi-Yu Liang, Xiao-Yu Du, Sheng-Jie Hou, Xiao-Lin Yu, Rui-Tian Liu
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2024)
Abstract Background Deoxyribonuclease 2 (DNase II) plays a key role in clearing cytoplasmic double-stranded DNA (dsDNA). Deficiency of DNase II leads to DNA accumulation in the cytoplasm. Persistent dsDNA in neurons is an early pathological hallmark
Externí odkaz:
https://doaj.org/article/7a9b0bec679c43d4b8d1202c43f3c6dc
Autor:
Sheng-jie Hou, Ya-ru Huang, Jie Zhu, Ying-bo Jia, Xiao-yun Niu, Jin-ju Yang, Xiao-lin Yu, Xiao-yu Du, Shi-yu Liang, Fang Cui, Ling-jie Li, Chen Tian, Rui-tian Liu
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-18 (2024)
Abstract The elderly frequently present impaired blood–brain barrier which is closely associated with various neurodegenerative diseases. However, how the albumin, the most abundant protein in the plasma, leaking through the disrupted BBB, contribu
Externí odkaz:
https://doaj.org/article/f9daa4180fdd4446bfb2696aee353476
Autor:
Xiao-yun Niu, Xi-xiu Xie, Hou-zhen Tuo, Cui-ping Lv, Ya-ru Huang, Jie Zhu, Shi-yu Liang, Xiao-yu Du, Cheng-gang Yang, Sheng-jie Hou, Xiao-ying Sun, Ling-jie Li, Fang Cui, Qi-xin Huang, Ying-bo Jia, Yu-jiong Wang, Rui-tian Liu
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. We here first found that thr
Externí odkaz:
https://doaj.org/article/74621297ce3f44dbbbe78cb2be9d79f1
Autor:
Yinchuan Li, Lei Li, Guanghao Wu, Gangcai Xie, Lirong Yi, Jie Zhu, ShiYu Liang, Ya‐ru Huang, Juan Chen, Shaoyang Ji, Fei Sun, Rui‐tian Liu
Publikováno v:
MedComm, Vol 4, Iss 5, Pp n/a-n/a (2023)
Abstract Aged male patients are more vulnerable to severe or critical symptoms of COVID‐19, but the underlying mechanism remains elusive. In this study, we analyzed previously published scRNA‐seq data from a large cohort of COVID‐19 patients, c
Externí odkaz:
https://doaj.org/article/bc60874592334979887655ac7b59b49f
Autor:
Xiao-ying Sun, Xiao-lin Yu, Jie Zhu, Ling-jie Li, Lun Zhang, Ya-ru Huang, Dong-qun Liu, Mei Ji, Xun Sun, Ling-xiao Zhang, Wei-wei Zhou, Dongming Zhang, Jianwei Jiao, Rui-tian Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease (AD). However, almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitiv
Externí odkaz:
https://doaj.org/article/e1dfffcdcd3a499c9362a619cc60c54a
Autor:
Ya-ru Huang, Xi-xiu Xie, Jing Yang, Xiao-ying Sun, Xiao-yun Niu, Cheng-gang Yang, Ling-jie Li, Lun Zhang, Dan Wang, Chun-yu Liu, Sheng-jie Hou, Chen-yang Jiang, Yu-ming Xu, Rui-tian Liu
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112624- (2023)
Summary: Amyloid-β (Aβ) plays an important role in the neuropathology of Alzheimer’s disease (AD), but some factors promoting Aβ generation and Aβ oligomer (Aβo) neurotoxicity remain unclear. We here find that the levels of ArhGAP11A, a Ras ho
Externí odkaz:
https://doaj.org/article/0fc98a5893394101a62f5db921a73f36
Autor:
Xiao-ying Sun, Ling-jie Li, Quan-Xiu Dong, Jie Zhu, Ya-ru Huang, Sheng-jie Hou, Xiao-lin Yu, Rui-tian Liu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-14 (2021)
Abstract Background Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies. During disease progression, abnormally phosphorylated forms of tau aggregate and accumulate into neurofibrillary tangles, leading to synapse loss, ne
Externí odkaz:
https://doaj.org/article/6b577e9e1eee4e68bb1f8166bdba0d99
Autor:
Xiao-ge Liu, Lun Zhang, Shuai Lu, Dong-qun Liu, Ya-ru Huang, Jie Zhu, Wei-wei Zhou, Xiao-lin Yu, Rui-tian Liu
Publikováno v:
Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-13 (2020)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder. No disease-modifying strategy to prevent or delay AD progression currently exists. Aβ oligomers (AβOs), rather than monomers or fibrils, are considered as t
Externí odkaz:
https://doaj.org/article/96ff639954c94c9cba334d83b238166b
Autor:
Ya-ru Huang, Xi-xiu Xie, Mei Ji, Xiao-lin Yu, Jie Zhu, Ling-xiao Zhang, Xiao-ge Liu, Chen Wei, Gang Li, Rui-tian Liu
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 202-217 (2019)
It has been suggested that aggregation of α-synuclein (α-syn) into oligomers leads to neurodegeneration in Parkinson's disease (PD), but intravenous immunoglobulin (IVIG) which contains antibodies against α-syn monomers and oligomers fails to trea
Externí odkaz:
https://doaj.org/article/e32fd0b6658847ebacb36342141d1ef6
Autor:
Mei Ji, Xi-xiu Xie, Dong-qun Liu, Xiao-lin Yu, Yue Zhang, Ling-Xiao Zhang, Shao-wei Wang, Ya-ru Huang, Rui-tian Liu
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2018)
Abstract Background Truncated mis-disordered tau protein plays an important role in the pathogenesis of Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau294–305, an epitope in the truncated tau, is essential for pathological tau-tau
Externí odkaz:
https://doaj.org/article/f50953cb30a846db91d8dca212459126