Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rui-Xun Zhao"'
Autor:
Qian-Hui Sun, Yi-Shu Wang, Guolong Liu, Hong-Lan Zhou, Yong-Ping Jian, Ming-Di Liu, Dan Zhang, Qiang Ding, Rui-Xun Zhao, Jian-Feng Chen, Yi-Ning Li, Jiyong Liang, Yu-Lin Li, Cheng-Shi Quan, Zhi-Xiang Xu
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Background: Treatment of Crohn's disease (CD) remains to be a challenge due to limited insights for its pathogenesis. We aimed to determine the role of O-Linked β-N-acetylglucosamine (O-GlcNAc) in the development of CD and evaluate therapeutic effec
Externí odkaz:
https://doaj.org/article/4b9e38c85ca54b078c52a29c2fd8865a
Autor:
Ying Zhao, Zhi-Xiang Xu, Long-Jiang Xu, Rui-Xun Zhao, Yong Wang, Kaitlin D. Werle, Li-Yan Jin, Feng-Mei Cui, Xiao-Long Liu, Zhuo-Jun Wu, Kui Zhao, Ke Zhang, Qiu Chen, Guo-Qin Jiang
Publikováno v:
Aging (Albany NY)
Inactivating mutations in the liver kinase B1 (LKB1) tumor suppressor gene underlie Peutz-Jeghers syndrome (PJS) and occur frequently in various human cancers. We previously showed that LKB1 regulates centrosome duplication via PLK1. Here, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51f312cbb8829af96b46071fc46c520
https://doi.org/10.18632/aging.103473
https://doi.org/10.18632/aging.103473
Autor:
Wei Hang, Dong-Dong Li, Rui-Xun Zhao, Yu-Lin Li, Cheng-Shi Quan, Qinghua Zeng, Xiangfeng Shen, Qian-Hui Sun, Qiang Ding, Yong-Ping Jian, Yang-He Zhang, Zhi-Xian Yin, Yishu Wang, Gang Liu, Zhi-Xiang Xu
Publikováno v:
Oncotarget
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. Mutations of TP53 may reach 70% - 85% in HNSCC patients without human papillomavirus (HPV) infection. Recurrence rate remains particularly high for HNSCC patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a0815cadd187bd54a59bcdaf1042dd
http://europepmc.org/articles/PMC5788606
http://europepmc.org/articles/PMC5788606
Autor:
Yu-Lin Li, Jianfeng Chen, Zhi-Xiang Xu, Shuai Wang, Huibo Wang, Yong Ping Jian, Yi Shu Wang, Xiang Feng Shen, Qinghua Zeng, Jian-Wei Wang, Rutao Cui, Rui Xun Zhao, Kaitlin D. Werle, Jiyong Liang, Cheng Shi Quan, Ying Xian Zhai, Wei Hang, Feng-Mei Cui
Publikováno v:
Oncotarget
Liver kinase B1 (LKB1) functions as a tumor suppressor encoded by STK11, a gene that mutated in Peutz-Jeghers syndrome and in sporadic cancers. Previous studies showed that LKB1 participates in IR- and ROS-induced DNA damage response (DDR). However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6527303855cd37a4ccb743fcd8422b61
https://doi.org/10.18632/oncotarget.12334
https://doi.org/10.18632/oncotarget.12334
Autor:
Fengmei Cui, Li-Yan Jin, Rui-Xun Zhao, Xiao-Long Liu, Qiu Chen, Ke Zhang, Ying Zhao, Guo-Qin Jiang, Zhi-Xiang Xu
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b92c967d61bd3b42d16e8e279c482fa3
https://doi.org/10.2139/ssrn.3212954
https://doi.org/10.2139/ssrn.3212954
Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1
Autor:
Yu-Lin Li, Yishu Wang, Zhi-Xiang Xu, Qinghua Zeng, Dong-Dong Li, Yong-Ping Jian, Qian-Hui Sun, Rui-Xun Zhao, Zhi-Xian Yin, Wei Hang, Xiangfeng Shen, Yang-He Zhang, Cheng-Shi Quan, Gang Liu
Publikováno v:
Oncogene
TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively explored to identify agents that target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cb87e462051b14a6c159253089a9aa
https://pubmed.ncbi.nlm.nih.gov/29348462
https://pubmed.ncbi.nlm.nih.gov/29348462
Autor:
Hyung-Gyoon Kim, Yu-Lin Li, Yibing Lu, Xuxian Xiao, Zhi-Xiang Xu, Ying-Xian Zhai, Jianfeng Chen, Kaitlin D. Werle, Rui-Xun Zhao, Hua-Guo Xu, Rutao Cui, Richard D. Lopez, Jian-Wei Wang, Jiyong Liang, Cheng-Shi Quan, Qiongqiong He
Publikováno v:
Oncogene
Liver kinase B1 (LKB1, also known as serine/threonine kinase 11, STK11) is a tumor suppressor mutated in Peutz-Jeghers syndrome and in a variety of sporadic cancers. Herein, we demonstrate that LKB1 controls the levels of intracellular reactive oxyge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9198d0d92398d8e71ccbb6feca9604f2
https://doi.org/10.1038/onc.2014.315
https://doi.org/10.1038/onc.2014.315
Autor:
Zhi-Xiang Xu, Rui-Xun Zhao
Publikováno v:
Current Drug Targets. 15:32-52
LKB1 (also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in Peutz-Jeghers syndrome (PJS) and in a variety of cancers. Physiologically, LKB1 possesses multiple cellular functions in the regulation of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de971489feb8e052cc910be7437613c2
https://doi.org/10.2174/1389450114666140106095811
https://doi.org/10.2174/1389450114666140106095811
Autor:
Wei Ming Zhang, Xiao Long Liu, Louise T. Chow, Yu-Lin Li, Jiyong Liang, Mariam Youssef, Rutao Cui, Zhi-Xiang Xu, Jianfeng Chen, Rui Xun Zhao, Yining Li, Ying Xian Zhai, Yi Shu Wang, Cheng Shi Quan, Xiang Dong Li, Qinghua Zeng, Nicholas J. Genovese, Jian-Wei Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(33)
High-risk human papillomaviruses (HPVs) are causative agents of anogenital cancers and a fraction of head and neck cancers. The mechanisms involved in the progression of HPV neoplasias to cancers remain largely unknown. Here, we report that O-linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a34ae434dd406b000198926e8b8f690
https://pubmed.ncbi.nlm.nih.gov/27482104
https://pubmed.ncbi.nlm.nih.gov/27482104
Autor:
Qinghua Zeng, Nicholas J. Genovese, Jianfeng Chen, Cheng-Shi Quan, Kaitlin D. Werle, Rutao Cui, Yining Li, Yishu Wang, Louise T. Chow, Yu-Lin Li, Mariam Youssef, Zhi-Xiang Xu, Jian-Wei Wang, Ying-Xian Zhai, Jiyong Liang, Rui-Xun Zhao
Publikováno v:
Oncogene
Liver kinase B1 (LKB1) is mutationally inactivated in Peutz-Jeghers syndrome and in a variety of cancers including human papillomavirus (HPV)-caused cervical cancer. However, the significance of LKB1 mutations in cervical cancer initiation and progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991f73ae650ffe39d9625fc5cf1414d0
https://pubmed.ncbi.nlm.nih.gov/27546620
https://pubmed.ncbi.nlm.nih.gov/27546620