Výsledky vyhledávání - "Rui T. Peixoto"

Abnormal Striatal Development Underlies the Early Onset of Behavioral Deficits in Shank3B−/− Mice

Autor: Wengang Wang, Rui T. Peixoto, James Levasseur, Lynne Chantranupong, Tasha Merchant, Richard Hakim, Bernardo L. Sabatini, Kelly Gorman, Bogdan Budnik

Publikováno v: Cell Reports, Vol 29, Iss 7, Pp 2016-2027.e4 (2019)
Cell reports

SUMMARY The neural substrates and pathophysiological mechanisms underlying the onset of cognitive and motor deficits in autism spectrum disorders (ASDs) remain unclear. Mutations in ASD-associated SHANK3 in mice (Shank3B−/−) result in the acceler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0810bd2b565ede94a1a1b3080d90884
http://www.sciencedirect.com/science/article/pii/S221112471931321X

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Interfacing with small brain volumes with tapered fiber-based optrode

Autor: Leonardo Sileo, Ferruccio Pisanello, Rui T. Peixoto, Bernardo L. Sabatini, M. DeVittorio, Marco Pisanello, Filippo Pisano, Barbara Spagnolo, John A. Assad

Publikováno v: Scopus-Elsevier

Optogenetics offers the possibility of understanding behavior-related neuronal circuits, using light to trigger neuronal response. The exploitation of unconventional microfabrication techniques has led to the development of different optoelectronic d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8330b09d3335b280cdf4210ab009c81c
https://doi.org/10.1364/boda.2021.jtu4a.14

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Integrated tapered fibertrode for simultaneous control and readout of neural activity over small brain volumes with reduced light-induced artefacts

Autor: M. De Vittorio, Leonardo Sileo, Barbara Spagnolo, Bernardo L. Sabatini, Ferruccio Pisanello, John A. Assad, Rui T. Peixoto, Marco Pisanello, Filippo Pisano

Recognizing the neural patterns underlying different brain functions is essential to achieve a more comprehensive view on how small sets of neurons organize in complex 3D networks to determine different behaviours. In this framework, optogenetic tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9bf2075c66ed746934e953d9676cefb
https://doi.org/10.1101/2020.07.31.226795

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Striatal circuit development and synapse maturation

Autor: Yevgenia Kozorovitskiy, Rui T. Peixoto

Publikováno v: Synapse Development and Maturation ISBN: 9780128236727

The basal ganglia are a series of subcortical nuclei essential for goal-directed motor actions and reward-based behavior in vertebrates. The goal of this chapter is to review the development of the striatum which is the largest nucleus and the main p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a59a202ee4951d5d38ae5f0458b0f7b1
https://doi.org/10.1016/b978-0-12-823672-7.00021-1

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Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production

Autor: José-Manuel Baizabal, Michael Y. Tolstorukov, Lauren A. English, Ya-Jun Xie, Diana N. Tran, Salvador Ignacio Brito, Corey C. Harwell, Wengang Wang, Matthew A. Booker, Rui T. Peixoto, Christopher M. Reid, Miguel Turrero García, Manal A. Adam

Publikováno v: Development

The mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from the dorsal telencephalon, while inhibitory interneurons are generated in its ventral port

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cbde1cf75d4e19fb52aefd22c565d1
https://doi.org/10.1242/dev.187526

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Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production

Autor: Rui T. Peixoto, Wengang Wang, Miguel Turrero García, Matthew A. Booker, José-Manuel Baizabal, Salvador Ignacio Brito, Ya-Jun Xie, Michael Y. Tolstorukov, Manal A. Adam, Diana A. Tran, Corey C. Harwell

SUMMARYThe mammalian cortex is populated by neurons derived from neural progenitors located throughout the embryonic telencephalon. Excitatory neurons are derived from progenitors located in the dorsal telencephalon, while inhibitory interneurons are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f819d7011c713b062f907fbaa9511f5

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Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice

Autor: Rui T. Peixoto, Yevgenia Kozorovitskiy, Donyell M Croney, Bernardo L. Sabatini, Wengang Wang

Publikováno v: Nature neuroscience

Some autistic individuals exhibit abnormal development of the caudate nucleus and associative cortical areas, suggesting potential dysfunction of cortico-basal ganglia (BG) circuits. Using optogenetic and electrophysiological approaches in mice, we i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9546907e6d056a0e703844329c3160b1
http://europepmc.org/articles/PMC4846490

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Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships

Autor: Hong Lu, Peng Zhang, Parastoo Azadi, Kenji F. Tanaka, Mary Pines, Tabrez J. Siddiqui, Yicheng Xie, Michael D. Gordon, Bernardo L. Sabatini, Wenlan Wu, Rachel O.L. Wong, Shinichiro Oku, Rui T. Peixoto, Yuan Ge, A. Radu Aricescu, Ann Marie Craig, Stephanie A. Archer-Hartmann, Keitaro Yoshida

Publikováno v: Cell. 174(6)

Synapses are fundamental units of communication in the brain. The prototypical synapse-organizing complex neurexin-neuroligin mediates synapse development and function and is central to a shared genetic risk pathway in autism and schizophrenia. Neure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f344b8e4500ba98ef21ff6ed9af83000
https://pubmed.ncbi.nlm.nih.gov/30193105

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