Adenosine A2A receptors control synaptic remodeling in the adult brain

Autor: Xinli Xu, Rui O. Beleza, Francisco Q. Gonçalves, Sergio Valbuena, Sofia Alçada-Morais, Nélio Gonçalves, Joana Magalhães, João M. M. Rocha, Sofia Ferreira, Ana S. G. Figueira, Juan Lerma, Rodrigo A. Cunha, Ricardo J. Rodrigues, Joana M. Marques

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)

Abstract The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber (MF) sprouting found in diseases such as temporal lobe epilepsy. T

Externí odkaz: https://doaj.org/article/eb8f8fcddb564941b72eac2840610363

Adenosine A2breceptors control A1receptor-mediated inhibition of synaptic transmission in the mouse hippocampus

Autor: Ricardo Gouveia Rodrigues, Cristina Lemos, Paula M. Canas, Joana Marques, Attila Köfalvi, Anna Pliássova, Rodrigo A. Cunha, Daniel Rial, Rui O. Beleza, Francisco Q. Gonçalves, Johny Pires

Publikováno v: European Journal of Neuroscience. 41:878-888

Adenosine is a neuromodulator mostly acting through A1 (inhibitory) and A2A (excitatory) receptors in the brain. A2B receptors (A(2B)R) are G(s/q)--protein-coupled receptors with low expression in the brain. As A(2B)R function is largely unknown, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d970d155018e5da03a7437e0e170aa99
https://doi.org/10.1111/ejn.12851

Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain

Autor: Bárbara S. Pinheiro, Rui O. Beleza, Cristina Lemos, Ricardo Gouveia Rodrigues, Attila Köfalvi, Joana Marques, Rodrigo A. Cunha, Daniel Rial

ATP consumption during intense neuronal activity leads to peaks of both extracellular adenosine levels and increased glucose uptake in the brain. Here, we investigated the hypothesis that the activation of the low-affinity adenosine receptor, the A2B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a83fd4bf9539b77142d6badb6a0f7e61
https://europepmc.org/articles/PMC4648789/

Adenosine A2A receptors control synaptic remodeling in the adult brain.

Autor: Xu, Xinli^1,2 (AUTHOR), Beleza, Rui O.¹ (AUTHOR), Gonçalves, Francisco Q.^1,2 (AUTHOR), Valbuena, Sergio³ (AUTHOR), Alçada-Morais, Sofia^1,2 (AUTHOR), Gonçalves, Nélio^1,2 (AUTHOR), Magalhães, Joana^1,2 (AUTHOR), Rocha, João M. M.^1,2 (AUTHOR), Ferreira, Sofia^1,2 (AUTHOR), Figueira, Ana S. G.¹ (AUTHOR), Lerma, Juan³ (AUTHOR), Cunha, Rodrigo A.^1,4 (AUTHOR), Rodrigues, Ricardo J.^1,2 (AUTHOR) ricardojrodrigues@gmail.com, Marques, Joana M.^1,2 (AUTHOR)

Publikováno v: Scientific Reports. 8/29/2022, Vol. 12 Issue 1, p1-17. 17p.

Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 receptor activation.

Autor: Simões, Ana P., Silva, Carla G., Marques, Joana M., Pochmann, Daniela, Porciúncula, Lisiane O., Ferreira, Sofia, Oses, Jean P., Beleza, Rui O., Real, Joana I., Köfalvi, Attila, Bahr, Ben A., Lerma, Juan, Cunha, Rodrigo A., Rodrigues, Ricardo J.

Publikováno v: Cell Death & Disease; Mar2018, Vol. 9 Issue 3, p1-1, 1p