Zobrazeno 1 - 10 of 97 pro vyhledávání: '"Rui M M, Victorino"'
1
Akademický článek
Monozygotic Twins Concordant for Common Variable Immunodeficiency: Strikingly Similar Clinical and Immune Profile Associated With a Polygenic Burden
Autor: Susana L. Silva, Mariana Fonseca, Marcelo L. M. Pereira, Sara P. Silva, Rita R. Barbosa, Ana Serra-Caetano, Elena Blanco, Pedro Rosmaninho, Martin Pérez-Andrés, Ana Berta Sousa, Alexandre A. S. F. Raposo, Margarida Gama-Carvalho, Rui M. M. Victorino, Lennart Hammarstrom, Ana E. Sousa
Publikováno v: Frontiers in Immunology, Vol 10 (2019)
Monozygotic twins provide a unique opportunity to better understand complex genetic diseases and the relative contribution of heritable factors in shaping the immune system throughout life. Common Variable Immunodeficiency Disorders (CVID) are primar
Externí odkaz: https://doaj.org/article/f08925a14492451396341b37449e3910
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2
Akademický článek
Blood cultures on internal medicine: utilization profile and clinical implications
Autor: Gustavo Nobre de Jesus, João Trindade Nave, Luís Santos Pinheiro, João Meneses Santos, Margarida Lucas, Rui M. M. Victorino
Publikováno v: Medicina, Vol 50, Iss 4 (2017)
Introduction: recent literature suggests that excessive use of blood cultures could prolong length of stay and hospital costs. Moreover, low positive rates have been reported and positivity predictive scores have recently been proposed. Methods: we c
Externí odkaz: https://doaj.org/article/a2144c50c8044e2ba3a6bec98bb6c0c9
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3
Akademický článek
Major CD4 T-Cell Depletion and Immune Senescence in a Patient with Chronic Granulomatous Disease
Autor: Adriana S. Albuquerque, Susana M. Fernandes, Rita Tendeiro, Rémi Cheynier, Margarida Lucas, Susana L. Silva, Rui M. M. Victorino, Ana E. Sousa
Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Chronic granulomatous disease (CGD) results from primary defects in phagocytic reactive oxygen species (ROS) production. T-cell evaluation is usually neglected during patients’ follow-up, although T-cell depletion has been reported in CGD through u
Externí odkaz: https://doaj.org/article/9c8f501011654e078d685f5de6eca40c
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4
Akademický článek
Disseminated Necrotizing Leukoencephalopathy Complicating Septic Shock in an Immunocompetent Patient
Autor: Pedro Gaspar-da-Costa, Sofia Reimão, Sandra Braz, João Meneses Santos, Rui M. M. Victorino
Publikováno v: Case Reports in Critical Care, Vol 2017 (2017)
Disseminated necrotizing leukoencephalopathy (DNL) is characterized by multiple microscopic foci of white matter necrosis. DNL was initially thought to be exclusively associated with immunosuppression conditions but it has been recently described in
Externí odkaz: https://doaj.org/article/635db93a206840e7864fd229e08074e2
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5
Akademický článek
Autoimmunity and allergy control in adults submitted to complete thymectomy early in infancy.
Autor: Susana L Silva, Adriana Albuquerque, Andreia J Amaral, Quan-Zhen Li, Catarina Mota, Rémi Cheynier, Rui M M Victorino, M Conceição Pereira-Santos, Ana E Sousa
Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180385 (2017)
The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict cr
Externí odkaz: https://doaj.org/article/4e5ab41235134d03abccbbe83e467049
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6
Akademický článek
Massive Bleeding as the First Clinical Manifestation of Metastatic Prostate Cancer due to Disseminated Intravascular Coagulation with Enhanced Fibrinolysis
Autor: Mónica Palma Anselmo, Gustavo Nobre de Jesus, João Madeira Lopes, Rui M. M. Victorino, João Meneses Santos
Publikováno v: Case Reports in Hematology, Vol 2016 (2016)
Disseminated intravascular coagulation (DIC) is the most frequent coagulation disorder associated with metastatic prostate adenocarcinoma. However, DIC with enhanced fibrinolysis as an initial presentation of prostate cancer is extremely rare. The ap
Externí odkaz: https://doaj.org/article/ebc9da2478424ea29885fd8631471902
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8
Akademický článek
Human FOXN1-deficiency is associated with αβ double-negative and FoxP3+ T-cell expansions that are distinctly modulated upon thymic transplantation.
Autor: Adriana S Albuquerque, José G Marques, Susana L Silva, Dario Ligeiro, Blythe H Devlin, Jacques Dutrieux, Rémi Cheynier, Claudio Pignata, Rui M M Victorino, M Louise Markert, Ana E Sousa
Publikováno v: PLoS ONE, Vol 7, Iss 5, p e37042 (2012)
Forkhead box N1 (FOXN1) is a transcription factor crucial for thymic epithelium development and prevention of its involution. Investigation of a patient with a rare homozygous FOXN1 mutation (R255X), leading to alopecia universalis and thymus aplasia
Externí odkaz: https://doaj.org/article/9f3b322d36ec49c49ade3fd6d5172c7d
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10
Akademický článek
Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.
Autor: Rita R Barbosa, Sara P Silva, Susana L Silva, Alcinda Campos Melo, Elisa Pedro, Manuel P Barbosa, M Conceição Pereira-Santos, Rui M M Victorino, Ana E Sousa
Publikováno v: PLoS ONE, Vol 6, Iss 8, p e22848 (2011)
IL-17 is a pro-inflammatory cytokine implicated in autoimmune and inflammatory conditions. The development/survival of IL-17-producing CD4 T cells (Th17) share critical cues with B-cell differentiation and the circulating follicular T helper subset w
Externí odkaz: https://doaj.org/article/67e7bfd0fa2d4302a11151d91282c83e
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