Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Rui J Sousa"'
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Changes in intracellular GTP levels are not considered as a regulatory event in RAC1 activation in live cells since total GTP levels are substantially higher than the RAC1 GTP dissociation constant determined in vitro. Here, the authors demonstrate t
Externí odkaz:
https://doaj.org/article/8aee079d643942f4a47c971818bffc85
Autor:
Anna Bianchi-Smiraglia, David W. Wolff, Daniel J. Marston, Zhiyong Deng, Zhannan Han, Sudha Moparthy, Rebecca M. Wombacher, Ashley L. Mussell, Shichen Shen, Jialin Chen, Dong-Hyun Yun, Anderson O’Brien Cox, Cristina M. Furdui, Edward Hurley, Maria Laura Feltri, Jun Qu, Thomas Hollis, Jules Berlin Nde Kengne, Bernard Fongang, Rui J. Sousa, Mikhail E. Kandel, Eugene S. Kandel, Klaus M. Hahn, Mikhail A. Nikiforov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/09f7fc50b96d4098b94d7fd143a62297
Autor:
Thomas Hollis, Maria Laura Feltri, Anderson O’Brien Cox, Jun Qu, Jules Berlin Nde Kengne, Zhiyong Deng, Jialin Chen, Rebecca M. Wombacher, Anna Bianchi-Smiraglia, Mikhail E. Kandel, Klaus M. Hahn, Shichen Shen, Sudha Moparthy, David W. Wolff, Bernard Fongang, Ashley L. Mussell, Eugene S. Kandel, Cristina M. Furdui, Rui J Sousa, Mikhail A. Nikiforov, Daniel J. Marston, Zhannan Han, Dong Hyun Yun, Edward Hurley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Autor:
Klaus M. Hahn, Shichen Shen, Jules Berlin Nde Kengne, Rebecca M. Wombacher, Anna Bianchi-Smiraglia, Mikhail A. Nikiforov, Jun Qu, Zhiyong Deng, Daniel J. Marston, Eugene S. Kandel, Zhannan Han, Cristina M. Furdui, Bernard Fongang, Dong Hyun Yun, Mikhail E. Kandel, Edward Hurley, Maria Laura Feltri, Anderson O’Brien Cox, Ashley L. Mussell, Jialin Chen, Thomas Hollis, Sudha Moparthy, David W. Wolff, Rui J Sousa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than th
Autor:
Rui J Sousa, Anna Bianchi-Smiraglia, Dominic J. Smiraglia, Mitra S. Rana, Brittany C. Lipchick, Sudha Moparthy, Edward Hurley, Hayley C. Affronti, Leslie M. Paul, Archis Bagati, Eugene S. Kandel, C E Foley, Kalyana Moparthy, Maria Laura Feltri, Mikhail A. Nikiforov, Emily E. Fink, Andrei V. Bakin
Publikováno v:
Nature methods
GTP is a major regulator of multiple cellular processes, but tools for quantitative evaluation of GTP levels in live cells have not been available. We report the development and characterization of genetically encoded GTP sensors, which we constructe
Autor:
Eileen M. Lafer, Rui J Sousa
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2334 (2019)
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2334 (2019)
Hsp70s use ATP to generate forces that disassemble protein complexes and aggregates, and that translocate proteins into organelles. Entropic pulling has been proposed as a novel mechanism, distinct from the more familiar power-stroke and Brownian rat
Autor:
Susan M. L. Banks, Rui J Sousa, Eileen M. Lafer, Subhojit Roy, Jennifer R. Morgan, Molly McQuillan, Ana Sofia Ibarraran-Viniegra, David J. Busch, Audrey T. Medeiros
α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b1cd344a8082e9f23805bb2d70afda
https://doi.org/10.1101/517524
https://doi.org/10.1101/517524
Publikováno v:
Neural Regeneration Research
Neural Regeneration Research, Vol 16, Iss 6, Pp 1198-1199 (2021)
Neural Regeneration Research, Vol 16, Iss 6, Pp 1198-1199 (2021)
Autor:
Suping Jin, Hsien-Shun Liao, Rui J Sousa, Albert J. Jin, Jorge Cuéllar, José M. Valpuesta, Eileen M. Lafer
Publikováno v:
Nature structural & molecular biology
Hsp70s use ATP hydrolysis to disrupt protein-protein associations and to move macromolecules. One example is the Hsc70- mediated disassembly of the clathrin coats that form on vesicles during endocytosis. Here, we exploited the exceptional features o
Autor:
Eileen M. Lafer, Ana Sofia Ibarraran-Viniegra, Audrey T. Medeiros, Jennifer R. Morgan, Molly McQuillan, Rui J Sousa, Susan M. L. Banks, David J. Busch
Publikováno v:
eNeuro
α-Synuclein overexpression and aggregation are linked to Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and several other neurodegenerative disorders. In addition to effects in the cell body, α-synuclein accumulation occurs at presyna