Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rui Climaco, Pinto"'
Autor:
Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang, Rui Climaco Pinto, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan, Samantha H. Y. Loh, Jeff W. Barclay, L. Miguel Martins, Raha Pazoki
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Biological pathways between alcohol consumption and alcohol liver disease (ALD) are not fully understood. We selected genes with known effect on (1) alcohol consumption, (2) liver function, and (3) gene expression. Expression of the ortholog
Externí odkaz:
https://doaj.org/article/0325f1b64d454089b354873fd13c3280
Autor:
Raha Pazoki, Marijana Vujkovic, Joshua Elliott, Evangelos Evangelou, Dipender Gill, Mohsen Ghanbari, Peter J. van der Most, Rui Climaco Pinto, Matthias Wielscher, Matthias Farlik, Verena Zuber, Robert J. de Knegt, Harold Snieder, André G. Uitterlinden, Lifelines Cohort Study, Julie A. Lynch, Xiyun Jiang, Saredo Said, David E. Kaplan, Kyung Min Lee, Marina Serper, Rotonya M. Carr, Philip S. Tsao, Stephen R. Atkinson, Abbas Dehghan, Ioanna Tzoulaki, M. Arfan Ikram, Karl-Heinz Herzig, Marjo-Riitta Järvelin, Behrooz Z. Alizadeh, Christopher J. O’Donnell, Danish Saleheen, Benjamin F. Voight, Kyong-Mi Chang, Mark R. Thursz, Paul Elliott, the VA Million Veteran Program
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Plasma levels of liver enzymes provide insights into hepatic function and related diseases. Here, the authors perform a genome-wide association study on three liver enzymes, identifying genetic variants associated with their plasma concentration as w
Externí odkaz:
https://doaj.org/article/4be589280cfe4d8ca12d31bf23d6016e
Autor:
Raha Pazoki, Evangelos Evangelou, David Mosen-Ansorena, Rui Climaco Pinto, Ibrahim Karaman, Paul Blakeley, Dipender Gill, Verena Zuber, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Levels of sodium and potassium in urine are associated with cardiovascular traits. Here, Pazoki et al. perform genome-wide association studies for urinary sodium and potassium secretion and identify 50 and 13 novel loci, respectively, some of which s
Externí odkaz:
https://doaj.org/article/b0491cd806ba41cd9e56d38859fd1475
Autor:
Felix O’Farrell, Benjamin Aleyakpo, Rima Mustafa, Xiyun Jiang, Rui Climaco Pinto, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan, Samantha H. Y. Loh, Jeff W. Barclay, L. Miguel Martins, Raha Pazoki
Alcohol consumption continues to cause a significant health burden globally. The advent of genome-wide association studies has unraveled many genetic loci associated with alcohol consumption. However, the biological effect of these loci and the pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60d383f4aeda4a45c520b6a011217587
https://doi.org/10.1101/2023.04.11.536418
https://doi.org/10.1101/2023.04.11.536418
Autor:
Rui Climaco Pinto, Ibrahim Karaman, Matthew R. Lewis, Jenny Hällqvist, Manuja Kaluarachchi, Gonçalo Graça, Elena Chekmeneva, Brenan Durainayagam, Mohsen Ghanbari, M. Arfan Ikram, Henrik Zetterberg, Julian Griffin, Paul Elliott, Ioanna Tzoulaki, Abbas Dehghan, David Herrington, Timothy Ebbels
Publikováno v:
Analytical Chemistry, 94(14), 5493-5503. American Chemical Society
Integration of multiple datasets can greatly enhance bioanalytical studies, for example, by increasing power to discover and validate biomarkers. In liquid chromatography-mass spectrometry (LC-MS) metabolomics, it is especially hard to combine untarg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec38e3be39612021db9688ffedb3d63
https://doi.org/10.1021/acs.analchem.1c03592
https://doi.org/10.1021/acs.analchem.1c03592
Autor:
Abbas, Dehghan, Rui Climaco, Pinto, Ibrahim, Karaman, Jian, Huang, Brenan R, Durainayagam, Mohsen, Ghanbari, Areesha, Nazeer, Qi, Zhong, Sonia, Liggi, Luke, Whiley, Rima, Mustafa, Miia, Kivipelto, Alina, Solomon, Tiia, Ngandu, Takahisa, Kanekiyo, Tomonori, Aikawa, Carola I, Radulescu, Samuel J, Barnes, Gonçalo, Graça, Elena, Chekmeneva, Stephane, Camuzeaux, Matthew R, Lewis, Manuja R, Kaluarachchi, M Arfan, Ikram, Elaine, Holmes, Ioanna, Tzoulaki, Paul M, Matthews, Julian L, Griffin, Paul, Elliott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(43)
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer's disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44758504b5724d9b2d5c5ea4c29cba19
https://pubmed.ncbi.nlm.nih.gov/36269859
https://pubmed.ncbi.nlm.nih.gov/36269859
Autor:
Abbas Dehghan, Rui Climaco Pinto, Ibrahim Karaman, Jian Huang, Brenan R. Durainayagam, Mohsen Ghanbari, Areesha Nazeer, Qi Zhong, Sonia Liggi, Luke Whiley, Rima Mustafa, Miia Kivipelto, Alina Solomon, Tiia Ngandu, Takahisa Kanekiyo, Tomonori Aikawa, Carola I. Radulescu, Samuel J. Barnes, Gonçalo Graça, Elena Chekmeneva, Stephane Camuzeaux, Matthew R. Lewis, Manuja R. Kaluarachchi, M. Arfan Ikram, Elaine Holmes, Ioanna Tzoulaki, Paul M. Matthews, Julian L. Griffin, Paul Elliott
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 119(43):e2206083119. National Academy of Sciences
Genome-wide association studies (GWASs) have identified genetic loci associated with the risk of Alzheimer’s disease (AD), but the molecular mechanisms by which they confer risk are largely unknown. We conducted a metabolome-wide association study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673c19cb621adb590cf6d6076a05edd5
http://hdl.handle.net/10044/1/100823
http://hdl.handle.net/10044/1/100823
Autor:
James L. Alexander, Coral Barbas, Frank W. Bonner, Lorraine Brennan, Julia C. Fussell, Simon J. Cameron, Raphaële Castagné, Marc Chadeau-Hyam, Rui Climaco Pinto, Olga Deda, Abbas Dehghan, Warwick B. Dunn, Timothy M.D. Ebbels, Paul Elliott, Evangelos Evangelou, Jeremy R. Everett, Dieter Galea, Jianliang Gao, Antonia García, Helen Gika, Robert C. Glen, Joanna Godzien, Elaine Holmes, Lesley Hoyles, Frank J. Kelly, Ibrahim Karaman, James M. Kinross, Ivan Laponogov, Matthew R. Lewis, John C. Lindon, Ángeles López-Gonzálvez, Lynn Maslen, Jeremy K. Nicholson, Kevin S. O’Neill, John A. Parkinson, Jake T.M. Pearce, Robert S. Plumb, Joram M. Posma, Nikolaos Raikos, Noureddin Sadawi, Reza M. Salek, Jonathan Swann, Zoltan Takats, Georgios Theodoridis, Ioanna Tzoulaki, Babar Vaqas, Kirill Veselkov, Ian D. Wilson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9d13d3f9fd8f9acb3e8905a5f6bca9a
https://doi.org/10.1016/b978-0-12-812293-8.09992-8
https://doi.org/10.1016/b978-0-12-812293-8.09992-8
Autor:
Rui Climaco, Pinto
Publikováno v:
Advances in experimental medicine and biology. 965
Chemometrics has been a fundamental discipline for the development of metabolomics, while symbiotically growing with it. From design of experiments, through data processing, to data analysis, chemometrics tools are used to design, process, visualize,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::030b83aa9ff2473d82feec97ee31b44d
https://pubmed.ncbi.nlm.nih.gov/28132180
https://pubmed.ncbi.nlm.nih.gov/28132180
Autor:
Millie, Rådjursöga, Göran B, Karlsson, Helen M, Lindqvist, Anders, Pedersen, Cecilia, Persson, Rui Climaco, Pinto, Lars, Ellegård, Anna, Winkvist
Publikováno v:
Food chemistry. 231
It is challenging to measure dietary exposure with techniques that are both accurate and applicable to free-living individuals. We performed a cross-over intervention, with 24 healthy individuals, to capture the acute metabolic response of a cereal b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::220cc31ca532fc17a091200669fe121c
https://pubmed.ncbi.nlm.nih.gov/28450006
https://pubmed.ncbi.nlm.nih.gov/28450006