The spatial-temporal dynamics of pulmonary blood flow are altered in pulmonary arterial hypertension

Autor: Abhilash S. Kizhakke Puliyakote, G. Kim Prisk, Ann R. Elliott, Nick H. Kim, Beni Pazar, Rui Carlos Sá, Amran K. Asadi, Susan R. Hopkins

Publikováno v: Journal of Applied Physiology. 134:969-979

Using proton MRI-arterial spin labeling to obtain serial images of pulmonary perfusion, we show that global fluctuation dispersion (FDglobal), a metric of temporal fluctuations in the spatial distribution of perfusion, was significantly increased in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b272778c3110b6ab2624783d6ca36aa7
https://doi.org/10.1152/japplphysiol.00463.2022

Ventilatory heterogeneity in the normal human lung is unchanged by controlled breathing

Autor: Eric T. Geier, G. Kim Prisk, Gregory M Petersen, Rui Carlos Sá

Publikováno v: J Appl Physiol (1985)

Measurement of ventilation heterogeneity with the multiple-breath nitrogen washout (MBW) is usually performed using controlled breathing with a fixed tidal volume and breathing frequency. However, it is unclear whether controlled breathing alters the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a2d3eb9c1204824c10488478463555
https://doi.org/10.1152/japplphysiol.00278.2020

Prone positioning redistributes gravitational stress in the lung in normal conditions and in simulations of oedema

Autor: Liza Botros, Tatsuya J. Arai, Rui Carlos Sá, Abhilash S. Kizhakke Puliyakote, Susan R. Hopkins, Sebastiaan Holverda, G. Kim Prisk, Harm Jan Bogaard, Rebecca J. Theilmann

Publikováno v: Experimental Physiology. Wiley-Blackwell Publishing Ltd
Kizhakke Puliyakote, A S, Holverda, S, Sá, R C, Arai, T J, Theilmann, R J, Botros, L, Bogaard, H J, Prisk, G K & Hopkins, S R 2020, ' Prone positioning redistributes gravitational stress in the lung in normal conditions and in simulations of oedema ', Experimental Physiology . https://doi.org/10.1113/EP089037
Exp Physiol

New Findings: What is the central question of this study? How does the interaction between posture and gravity affect the stresses on the lung, particularly in highly inflated gravitationally non-dependent regions, which are potentially vulnerable to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b8a8846018fd640d97f720cd4e7bd4
https://research.vumc.nl/en/publications/78aa5a13-366a-4de5-a66a-a387aa426f18

Ventilation-perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O2

Autor: Ann R. Elliott, Jeremy E. Orr, Abhilash S. Kizhakke Puliyakote, Rui Carlos Sá, Peter D. Wagner, Beni J Pazar, G. Kim Prisk, Vincent Tedjasaputra, Harrieth Wagner, Susan R. Hopkins

Publikováno v: Physiological reports, vol 8, iss 13
Physiological Reports, Vol 8, Iss 13, Pp n/a-n/a (2020)

Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ((Formula presented.)) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5fc2edb01e0cda9c2e5951ff4dbee52
https://escholarship.org/uc/item/2g9825f9

Controlled Breathing Does Not Alter Heterogeneity of Specific Ventilation in the Normal Lung

Autor: B. Thompson, Rui Carlos Sá, Gordon Kim Prisk, Eric T. Geier

Publikováno v: B30. ARTHUR DUBOIS MEMORIAL SESSION: THE SMALL AND LARGE OF AIRWAY AND LUNG FUNCTION.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e02ee8faef09c937dde9bc818d049516
https://doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2997