Supervised Exercise Patterns among Diabetic and Non-diabetic Portuguese Adults

Autor: Maria Esteves, Ana Gouveia, Ricardo Rodrigues, Paulo Pinheiro, Rui Bras, Kelly O'Hara, Paulo Duarte

Publikováno v: Annals of Applied Sport Science, Vol 7, Iss 3, Pp 49-56 (2019)

Background. Physical activity (PA) is a keystone of diabetes management, but although self-exercise is beneficial, supervised exercise (SE), adapted to individual characteristics, and is more effective. Objectives. The main research goal is to compar

Externí odkaz: https://doaj.org/article/403dc6139f494bbebc6ca9301abb8248

Preclinical assessment of cisplatin-based therapy versus docetaxel-based therapy on a panel of human non-small-cell lung cancer xenografts

Autor: Jean-Gabriel Judde, Pierre Laurent-Puig, Catherine Daniel, Fariba Nemati, Marie-France Poupon, Gonzague de Pinieux, Rui Bras-Gonçalves, Patricia de Cremoux, Vincent Bordier, Jean-Jacques Fontaine, Alain Livartowski, Didier Decaudin, A. Chapelier

Publikováno v: Anti-Cancer Drugs. 20:932-940

The success of treatment of advanced non-small-cell lung cancer (NSCLC) remains very poor. The aim of this study was, on a series of NSCLC xenografts, to compare the efficacy of standard cisplatin-based or docetaxel-based chemotherapy. Seven human xe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cf0418bebb3d921e8e829604bc1908
https://doi.org/10.1097/cad.0b013e32833009cc

Geraniol, a component of plant essential oils, modulates DNA synthesis and potentiates 5-fluorouracil efficacy on human colon tumor xenografts

Autor: Rui Bras-Gonçalves, S. Carnesecchi, Francine Gossé, Amyaouch Bradaïa, Francis Raul, Marie-France Poupon, Mirjam B. Zeisel

Publikováno v: Cancer Letters. 215:53-59

We investigated on colon cancer cells the effect of geraniol on thymidylate synthase and thymidine kinase expression, two enzymes related to 5-fluorouracil cytotoxicity. The anti-tumoral efficacy of geraniol and 5-fluorouracil were also evaluated on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf912ace69ec99c25293bd00bddfac5
https://doi.org/10.1016/j.canlet.2004.06.019

Breast tumor PDXs are genetically plastic and correspond to a subset of aggressive cancers prone to relapse

Autor: Tien-Tuan Nguyen, Laurence Lasorsa, Frédéric Bibeau, Charles Theillet, Béatrice Orsetti, Blandine Massemin, Florence Boissière, Rui Bras-Gonçalves, William Jacot, Stanislas du Manoir, Pierre-Emmanuel Colombo

Publikováno v: Molecular Oncology
Molecular Oncology, Elsevier, 2014, pp.431-43. ⟨10.1016/j.molonc.2013.11.010⟩
Molecular Oncology, 2014, pp.431-43. ⟨10.1016/j.molonc.2013.11.010⟩

Patient derived xenografts (PDXs) are increasingly appreciated models in cancer research, particularly for preclinical testing, as they reflect the patient's tumor biology more accurately than cancer cell lines. We have established a collection of 20

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e442a496348e4c5c7548787cfa7aa1
https://www.hal.inserm.fr/inserm-00942392/file/du_manoir_Ml_Onc_Figures_principales.pdf

Distinct Experimental Efficacy of Anti-Fas/APO-1/CD95 Receptor Antibody in Human Tumors

Autor: Dany Rouillard, Yveline Bourgeois, Arnaud Beurdeley-Thomas, Marie-France Poupon, Rui Bras Gonçalves, Laurent Miccoli, Pierre Pouillart, Didier Decaudin, Fariba Nemati

Publikováno v: Experimental Cell Research. 268:162-168

Ligation of the Fas receptor (FasR) is a key step in apoptosis induction. Using a series of human tumor cells (SNB19, SNB79, 143N2, and SHEP), we observed a distinct efficacy of human anti-FasR antibody with an apparent correlation with Fas cell surf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0be14e32cfb599f2793bbbb416d0fd1
https://doi.org/10.1006/excr.2001.5287