Výsledky vyhledávání - "Rui, Appelberg"

Akademický článek

IFNγ and iNOS-Mediated Alterations in the Bone Marrow and Thymus and Its Impact on Mycobacterium avium-Induced Thymic Atrophy

Autor: Palmira Barreira-Silva, Rita Melo-Miranda, Claudia Nobrega, Susana Roque, Cláudia Serre-Miranda, Margarida Borges, Gisela Armada, Daniela de Sá Calçada, Samuel M. Behar, Rui Appelberg, Margarida Correia-Neves

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Disseminated infection with the high virulence strain of Mycobacterium avium 25291 leads to progressive thymic atrophy. We previously showed that M. avium-induced thymic atrophy results from increased glucocorticoid levels that synergize with nitric

Externí odkaz: https://doaj.org/article/ef3b24afbdd0410794d401fc7fc77615

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Akademický článek

Advances on the Role and Applications of Interleukin-1 in Tuberculosis

Autor: Diogo Silvério, Rute Gonçalves, Rui Appelberg, Margarida Saraiva

Publikováno v: mBio, Vol 12, Iss 6 (2021)

ABSTRACT Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to its role in promoting inflammation and recruiting immune cells to the site of infection. In tuberculosis (TB), tight regulation of IL-1 responses is critical to

Externí odkaz: https://doaj.org/article/56361ddab88e4d21bf19c1fca8530659

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Akademický článek

Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection

Autor: Filipe Marques, Sílvia Vale-Costa, Tânia Cruz, Joana Moreira Marques, Tânia Silva, João Vilares Neves, Sofia Cortes, Ana Fernandes, Eduardo Rocha, Rui Appelberg, Pedro Rodrigues, Ana M. Tomás, Maria Salomé Gomes

Publikováno v: Parasites & Vectors, Vol 8, Iss 1, Pp 1-12 (2015)

Abstract Background Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L. infantum is the commonest agent of visc

Externí odkaz: https://doaj.org/article/dca6a0bfb58c45f5949929d36e8dafdf

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Advances on the Role and Applications of Interleukin-1 in Tuberculosis

Autor: Margarida Saraiva, Diogo Silvério, Rute Gonçalves, Rui Appelberg

Publikováno v: mBio, Vol 12, Iss 6 (2021)
CIÊNCIAVITAE
mBio

Interleukin-1 (IL-1) is a key player in the immune response to pathogens due to its role in promoting inflammation and recruiting immune cells to the site of infection. In tuberculosis (TB), tight regulation of IL-1 responses is critical to ensure ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89393d7ca3402d32fa6edf181475b4ae
https://journals.asm.org/doi/10.1128/mBio.03134-21

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IFNγ and iNOS-mediated alterations in the bone marrow and thymus and its impact onMycobacterium avium-induced thymic atrophy

Autor: Claudia Nobrega, Rita Melo-Miranda, Daniela de Sá Calçada, Margarida Borges, Samuel M. Behar, Palmira Barreira-Silva, Susana Roque, Margarida Correia-Neves, Rui Appelberg, Cláudia Serre-Miranda

Disseminated infection with the high virulence strain ofMycobacterium avium25291 lead to progressive thymic atrophy. We previously uncovered thatM. avium-induced thymic atrophy is due to increased levels of glucocorticoids synergizing with nitric oxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dbbf9a4e19e658c05d549d44a7cc118
https://doi.org/10.1101/2021.02.23.432464

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Akademický článek

Mycobacterium avium infection induces H-ferritin expression in mouse primary macrophages by activating Toll-like receptor 2.

Autor: Sandro Silva-Gomes, Cécile Bouton, Tânia Silva, Paolo Santambrogio, Pedro Rodrigues, Rui Appelberg, Maria Salomé Gomes

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82874 (2013)

Important for both host and pathogen survivals, iron is a key factor in determining the outcome of an infectious process. Iron with-holding, including sequestration inside tissue macrophages, is considered an important strategy to fight infection. Ho

Externí odkaz: https://doaj.org/article/b966aba8a26c433a85c46e0965d7099e

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Akademický článek

Iron overload favors the elimination of Leishmania infantum from mouse tissues through interaction with reactive oxygen and nitrogen species.

Autor: Sílvia Vale-Costa, Sandra Gomes-Pereira, Carlos Miguel Teixeira, Gustavo Rosa, Pedro Nuno Rodrigues, Ana Tomás, Rui Appelberg, Maria Salomé Gomes

Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 2, p e2061 (2013)

Iron plays a central role in host-parasite interactions, since both intervenients need iron for survival and growth, but are sensitive to iron-mediated toxicity. The host's iron overload is often associated with susceptibility to infection. However,

Externí odkaz: https://doaj.org/article/b919dd1cb3764a2f97a61b02ba68eb44

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Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils

Publikováno v: Mucosal Immunology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Modulation of immunity and disease by glycans is increasingly recognized. However, how host glycosylation shapes and is shaped by tuberculosis remains poorly understood. We show that deficiency in the glucosaminyl (N-acetyl) transferase 1 (Gcnt1), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e459be3f9d4c377b3b5219f99c2aa7
https://ddd.uab.cat/record/238780

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Akademický článek

Leishmania mitochondrial peroxiredoxin plays a crucial peroxidase-unrelated role during infection: insight into its novel chaperone activity.

Autor: Helena Castro, Filipa Teixeira, Susana Romao, Mariana Santos, Tânia Cruz, Manuela Flórido, Rui Appelberg, Pedro Oliveira, Frederico Ferreira-da-Silva, Ana M Tomás

Publikováno v: PLoS Pathogens, Vol 7, Iss 10, p e1002325 (2011)

Two-cysteine peroxiredoxins are ubiquitous peroxidases that play various functions in cells. In Leishmania and related trypanosomatids, which lack catalase and selenium-glutathione peroxidases, the discovery of this family of enzymes provided the mol

Externí odkaz: https://doaj.org/article/570e7538ecc04c528517a049fc35542d

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TNF-mediated compensatory immunity to mycobacterium avium in the absence of macrophage activation by IFN-γ

Autor: Marcos S. Cardoso, Margarida Borges, António G. Castro, Ricardo Fróis-Martins, Michael B. Jordan, Rui Appelberg, Mariana Resende

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Granuloma formation is a hallmark of several infectious diseases, including those caused by Mycobacterium sp These structures are composed of accumulations of inflammatory cells, and it has been shown that cytokines such as IFN-γ and TNF-α are requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca87af55fcd092a067035b73d433069
https://hdl.handle.net/1822/67360

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