Hemoglobin Interacts with Endothelial Nitric Oxide Synthase to Regulate Vasodilation in Human Resistance Arteries

Autor: Ma D, Smith R, Hans Ackerman, Juraj Kabat, Sundar Ganesan, Kamenyeva O, Brant E. Isakson, Ruhl Ap, Jeremy L. Davis, Phillip Cruz, Zeng X, Steven David Brooks

BackgroundIn small arteries, constriction of vascular smooth muscle triggers local release of nitric oxide from the adjacent endothelial cell. This feedback vasodilation is a homeostatic mechanism that opposes vasoconstriction. Here, we investigate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a974a231e05f46a40579ef6bbcd433d8
https://doi.org/10.1101/2021.04.06.21255004

Charting the Waters of Sickle Cell Disease With Target Trial Emulation.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.; Critical Care Medicine and Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Hsieh MM; Cellular and Molecular Therapeutics Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland., Stuart EA; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

Publikováno v: JAMA internal medicine [JAMA Intern Med] 2024 Nov 01; Vol. 184 (11), pp. 1372-1373.

Association of alpha globin gene copy number with exhaled nitric oxide in a cross-sectional study of healthy Black adults.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA parker.ruhl@nih.gov.; Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA., Jackson JM; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Carhuas CJ; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Niño de Rivera JG; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Fay MP; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Weinberg JB; Department of Medicine and Division of Hematology, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA., Que LG; Department of Medicine and Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University School of Medicine and Durham VA Medical Centers, Durham, North Carolina, USA., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Publikováno v: BMJ open respiratory research [BMJ Open Respir Res] 2023 Dec 20; Vol. 10 (1). Date of Electronic Publication: 2023 Dec 20.

Alpha globin gene copy number and hypertension risk among Black Americans.

Autor: Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America., Jeffries N; Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America., Yang Y; Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Rockville, Maryland, United States of America., Gutierrez OM; Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Muntner P; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Naik RP; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Pecker LH; Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America., Mott BT; University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States of America., Zakai NA; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America., Safford MM; Department of Medicine, Weill Cornell Medicine, New York, New York, United States of America., Lange LA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado, Denver, Colorado, United States of America., Winkler CA; Basic Research Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America., Cushman M; Department of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America.; Department of Pathology & Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, United States of America., Ackerman HC; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Publikováno v: PloS one [PLoS One] 2022 Jul 14; Vol. 17 (7), pp. e0271031. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).

Long-term tolerability of phosphodiesterase-5 inhibitors in pulmonary hypertension of sickle cell disease.

Autor: Cramer-Bour C; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Ruhl AP; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Nouraie SM; Division of Pulmonary, Asthma and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Emeh RO; Howard University College of Medicine, Washington, DC, USA., Ruopp NF; Division of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, MA, USA., Thein SL; Sickle Cell Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Weir NA; Pulmonary Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Klings ES; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; The Pulmonary Center, Boston University School of Medicine, Boston, MA, USA.

Publikováno v: European journal of haematology [Eur J Haematol] 2021 Jul; Vol. 107 (1), pp. 54-62. Date of Electronic Publication: 2021 Apr 15.