Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ruhi Deshmukh"'
Autor:
Tobias Ackermann, Engy Shokry, Ruhi Deshmukh, Jayanthi Anand, Laura C A Galbraith, Louise Mitchell, Giovanny Rodriguez-Blanco, Victor H Villar, Britt Amber Sterken, Colin Nixon, Sara Zanivan, Karen Blyth, David Sumpton, Saverio Tardito
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 11, Pp 2749-2774 (2024)
Abstract The limited availability of therapeutic options for patients with triple-negative breast cancer (TNBC) contributes to the high rate of metastatic recurrence and poor prognosis. Ferroptosis is a type of cell death caused by iron-dependent lip
Externí odkaz:
https://doaj.org/article/10957b6640e845b78b80022107f4701b
Autor:
Giuseppe Taurino, Ruhi Deshmukh, Victor H. Villar, Martina Chiu, Robin Shaw, Ann Hedley, Engy Shokry, David Sumpton, Erica Dander, Giovanna D'Amico, Ovidio Bussolati, Saverio Tardito
Publikováno v:
Molecular Metabolism, Vol 63, Iss , Pp 101532- (2022)
Bone marrow mesenchymal stromal cells (MSCs) have immunomodulatory and regenerative potential. However, culture conditions govern their metabolic processes and therapeutic efficacy. Here we show that culturing donor-derived MSCs in Plasmax™, a phys
Externí odkaz:
https://doaj.org/article/47c59b78a8d14a85bc297a7ea42c62d0
Autor:
Victor H. Villar, Maria Francesca Allega, Ruhi Deshmukh, Tobias Ackermann, Mark A. Nakasone, Johan Vande Voorde, Thomas M. Drake, Janina Oetjen, Algernon Bloom, Colin Nixon, Miryam Müller, Stephanie May, Ee Hong Tan, Lars Vereecke, Maude Jans, Gillian Blancke, Daniel J. Murphy, Danny T. Huang, David Y. Lewis, Thomas G. Bird, Owen J. Sansom, Karen Blyth, David Sumpton, Saverio Tardito
Publikováno v:
NATURE CHEMICAL BIOLOGY
Villar, V H, Allega, M F, Deshmukh, R, Ackermann, T, Nakasone, M A, Voorde, J V, Drake, T, Oetjen, J, Bloom, A, Nixon, C, Vereecke, L, Jans, M, Blancke, G, Bird, T G, Lewis, D, Sansom, O J, Blyth, K, Sumpton, D & Tardito, S 2022, ' Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer ', Nature Chemical Biology . https://doi.org/10.1038/s41589-022-01154-9
Villar, V H, Allega, M F, Deshmukh, R, Ackermann, T, Nakasone, M A, Voorde, J V, Drake, T, Oetjen, J, Bloom, A, Nixon, C, Vereecke, L, Jans, M, Blancke, G, Bird, T G, Lewis, D, Sansom, O J, Blyth, K, Sumpton, D & Tardito, S 2022, ' Hepatic glutamine synthetase controls N5-methylglutamine in homeostasis and cancer ', Nature Chemical Biology . https://doi.org/10.1038/s41589-022-01154-9
Glutamine synthetase (GS) activity is conserved from prokaryotes to humans, where the ATP-dependent production of glutamine from glutamate and ammonia is essential for neurotransmission and ammonia detoxification. Here, we show that mammalian GS uses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d644a6f88baef6ab2fcb6f68543200e9
https://doi.org/10.1038/s41589-022-01154-9
https://doi.org/10.1038/s41589-022-01154-9
Autor:
Giulia Avellino, Ruhi Deshmukh, Stephanie N. Rogers, D. Stephen Charnock-Jones, Gordon C. S. Smith, Saverio Tardito, Irving L. M. H. Aye
Human trophoblast cultures provide powerful tools to model key processes of placental development. In vitro trophoblast studies to date have relied on commercial media that contains nonphysiological levels of nutrients, and the impact of these condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6540e2f35fac0056ab9f754a6f0f30
Publikováno v:
Trends in molecular medicine. 27(11)
The frequent occurrence of neomorphic isocitrate dehydrogenase 1 (IDH1) mutations in low-grade glioma led to an IDH-centric classification of these tumors. However, exploiting metabolic alterations of glioma for diagnostic imaging and treatment has m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04711e9a77e8f0456e35f827223602e5
https://pubmed.ncbi.nlm.nih.gov/34489164
https://pubmed.ncbi.nlm.nih.gov/34489164
Autor:
Marc Sitbon, Michaela Fontenay, Marie Daumur, Julien Papoin, Naomi Taylor, Hongxia Yan, Ira Phadke, Anne-Sophie Dumé, Sandrina Kinet, Narla Mohandas, Valérie S. Zimmermann, Phuong-Nhi Bories, Xiuli An, Ruhi Deshmukh, Manuela Romano, Pedro Gonzalez-Menendez, Xiaoli Qu, Valerie Dardalhon, Cédric Mongellaz, Saverio Tardito, Patrick G. Gallagher, Leal Oburoglu, Lionel Blanc
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (5), pp.108723. ⟨10.1016/j.celrep.2021.108723⟩
Cell Rep
Cell Reports, Elsevier Inc, 2021, 34 (5), pp.108723. ⟨10.1016/j.celrep.2021.108723⟩
Cell Rep
The metabolic changes controlling the stepwise differentiation of hematopoietic stem and progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that HSPC development to an erythroid-committed proerythroblast results in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ccb8919a4bd55b40eb15cb7db34acc
https://hal.archives-ouvertes.fr/hal-03161590
https://hal.archives-ouvertes.fr/hal-03161590