Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ruhel Ahmad"'
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)
Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.
Externí odkaz:
https://doaj.org/article/b648848b74c14840be9be48f8be10660
Autor:
Nils Offen, Johannes Flemming, Hares Kamawal, Ruhel Ahmad, Wanja Wolber, Christian Geis, Holm Zaehres, Hans R. Schöler, Hannelore Ehrenreich, Albrecht M. Müller, Anna-Leena Sirén
Publikováno v:
Molecular Medicine, Vol 19, Iss 1, Pp 399-408 (2013)
Abstract Induced cell fate changes by reprogramming of somatic cells offers an efficient strategy to generate autologous pluripotent stem (iPS) cells from any adult cell type. The potential of iPS cells to differentiate into various cell types is wel
Externí odkaz:
https://doaj.org/article/07da94e9de7049ff8178c513fd1b70c5
Publikováno v:
Cells, Vol 7, Iss 9, p 140 (2018)
Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in thinking, perception, emotion, language, sense of self, and behavior. Epidemiological evidence suggests that subtle perturbations in early neurodevelopment i
Externí odkaz:
https://doaj.org/article/9684b131696c47bbbb4d08208fb4b039
Autor:
Ruhel Ahmad, Wanja Wolber, Sigrid Eckardt, Philipp Koch, Jessica Schmitt, Ruslan Semechkin, Christian Geis, Manfred Heckmann, Oliver Brüstle, John K McLaughlin, Anna-Leena Sirén, Albrecht M Müller
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42800 (2012)
Parent of origin imprints on the genome have been implicated in the regulation of neural cell type differentiation. The ability of human parthenogenetic (PG) embryonic stem cells (hpESCs) to undergo neural lineage and cell type-specific differentiati
Externí odkaz:
https://doaj.org/article/c57bc4aeedc64ee5a7df3b27f23bb6a2
Autor:
Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Publikováno v:
Nature Communications, 13(1):4819. Nature Publishing Group UK
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Schmidt, S, Luecken, M D, Trümbach, D, Hembach, S, Niedermeier, K M, Wenck, N, Pflügler, K, Stautner, C, Böttcher, A, Lickert, H, Ramirez-Suastegui, C, Ahmad, R, Ziller, M J, Fitzgerald, J C, Ruf, V, van de Berg, W D J, Jonker, A J, Gasser, T, Winner, B, Winkler, J R, Vogt Weisenhorn, D M, Giesert, F, Theis, F J & Wurst, W 2022, ' Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease ', Nature Communications, vol. 13, no. 1, 4819 . https://doi.org/10.1038/s41467-022-32229-9
Nature Communications 13(1), 4819 (2022). doi:10.1038/s41467-022-32229-9
Parkinson’s disease (PD) as a progressive neurodegenerative disorder arises from multiple genetic and environmental factors. However, underlying pathological mechanisms remain poorly understood. Using multiplexed single-cell transcriptomics, we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbe9488b2ba42a49814c207703256ed
https://pubmed.ncbi.nlm.nih.gov/35974013
https://pubmed.ncbi.nlm.nih.gov/35974013
Publikováno v:
Translational Neuroscience ISBN: 9781489976529
Neural stem cells (NSCs) are potentially attractive cell sources for reconstruction of injured spinal cord circuits. Recent studies demonstrate that NSCs can survive grafting into sites of severe spinal cord injury (SCI) and extend very large numbers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647dd1ec6687bd1df31b15c61d25f138
https://doi.org/10.1007/978-1-4899-7654-3_16
https://doi.org/10.1007/978-1-4899-7654-3_16
Publikováno v:
Cells, Vol 7, Iss 9, p 140 (2018)
Cells
CELLS
Cells
CELLS
Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in thinking, perception, emotion, language, sense of self, and behavior. Epidemiological evidence suggests that subtle perturbations in early neurodevelopment i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a148bddfd9f3973d3cb4efcf8010b7d2
https://doi.org/10.3390/cells7090140
https://doi.org/10.3390/cells7090140
Autor:
Gunnar Poplawski, Ruhel Ahmad, Paul Lu, Yaozhi Wang, Di Wu, Grace Woodruff, Matt Hunt, John H. Brock, Mark H. Tuszynski, Lawrence S.B. Goldstein, Eileen Boehle, Lori Graham
Publikováno v:
Neuron, vol 83, iss 4
Summary Human induced pluripotent stem cells (iPSCs) from a healthy 86-year-old male were differentiated into neural stem cells and grafted into adult immunodeficient rats after spinal cord injury. Three months after C5 lateral hemisections, iPSCs su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df86e439ddf970dfdd833598d79771ac
https://escholarship.org/uc/item/956176gw
https://escholarship.org/uc/item/956176gw
Autor:
Wanja Wolber, Christian Geis, Albrecht M. Müller, Hannelore Ehrenreich, Holm Zaehres, Ruhel Ahmad, Nils Offen, Anna-Leena Sirén, Hares Kamawal, Hans R. Schöler, Johannes Flemming
Publikováno v:
Molecular Medicine
Induced cell fate changes by reprogramming of somatic cells offers an efficient strategy to generate autologous pluripotent stem (iPS) cells from any adult cell type. The potential of iPS cells to differentiate into various cell types is well establi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b73607a2f6a2856db24001ccf98470c
https://pubmed.ncbi.nlm.nih.gov/24408113
https://pubmed.ncbi.nlm.nih.gov/24408113
Autor:
Wanja Wolber, Ruhel Ahmad, Christian Geis, Sigrid Eckardt, McLaughlin Kj, Jessica Schmitt, Anna-Leena Sirén, Manfred Heckmann, Albrecht M. Müller, Soon Won Choi
Uniparental zygotes with two paternal (androgenetic, AG) or two maternal genomes (gynogenetic, GG) cannot develop into viable offsprings but form blastocysts from which pluripotent embryonic stem (ES) cells can be derived. For most organs, it is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae0f1a6ae445f7c2b96b316a82a457c
https://europepmc.org/articles/PMC4733915/
https://europepmc.org/articles/PMC4733915/