Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ruggiero Pio Cassatella"'
Autor:
Vasiliki Panagiotakopoulou, Dina Ivanyuk, Silvia De Cicco, Wadood Haq, Aleksandra Arsić, Cong Yu, Daria Messelodi, Marvin Oldrati, David C. Schöndorf, Maria-Jose Perez, Ruggiero Pio Cassatella, Meike Jakobi, Nicole Schneiderhan-Marra, Thomas Gasser, Ivana Nikić-Spiegel, Michela Deleidi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
IFN-γ signalling is linked to regional neuronal vulnerability in Parkinson’s disease. The authors show that a PD-associated pathogenic LRRK2 missense mutation increases neuronal susceptibility to immune challenges via negative regulation of AKT ph
Externí odkaz:
https://doaj.org/article/352a040e1e54496bbea8ac57b66898c7
Autor:
Marvin Oldrati, Daria Messelodi, Ivana Nikić-Spiegel, Maria-Jose Perez, Cong Yu, Aleksandra Arsić, Thomas Gasser, David C. Schöndorf, Vasiliki Panagiotakopoulou, Dina Ivanyuk, Meike Jakobi, Ruggiero Pio Cassatella, Silvia De Cicco, Michela Deleidi, Wadood Haq, Nicole Schneiderhan-Marra
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4
Nature Communications
Nature Communications 11(1), 5163 (2020). doi:10.1038/s41467-020-18755-4
Parkinson’s disease-associated kinase LRRK2 has been linked to IFN type II (IFN-γ) response in infections and to dopaminergic neuronal loss. However, whether and how LRRK2 synergizes with IFN-γ remains unclear. In this study, we employed dopamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ac34786697a3cff0d6b047aa772ef7
http://link.springer.com/article/10.1038/s41467-020-18755-4
http://link.springer.com/article/10.1038/s41467-020-18755-4
Autor:
Aleksandra Arsić, David C. Schöndorf, Cong Yu, Ivana Nikić-Spiegel, Nicole Schneiderhan-Marra, Vasiliki Panagiotakopoulou, Michela Deleidi, Maria-Jose Perez, Silvia De Cicco, Meike Jakobi, Dina Ivanyuk, Wadood Haq, Thomas Gasser, Ruggiero Pio Cassatella
Increasing evidence suggests a role for interferons (IFNs) in neurodegeneration. Parkinson’s disease (PD) associated kinase LRRK2 has been implicated in IFN type II (IFN) response in infections and nigral neuronal loss. However, whether and how LRR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a64db894735af8f4c5dddd6329314aca
https://doi.org/10.1101/2020.01.30.925222
https://doi.org/10.1101/2020.01.30.925222
