Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ruggero Galici"'
Autor:
Claudia Meyer, Daniel Adkins, Koyena Pal, Ruggero Galici, Augusto Garcia-Agundez, Carsten Eickhoff
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: A steep increase in new drug applications has increased the overhead of writing technical documents such as medication guides. Natural language processing can contribute to reducing this burden.Objective: To generate medication guides fro
Externí odkaz:
https://doaj.org/article/9d4a6f1835874d0e86bb98377a053078
Autor:
Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser, Brian Lord, Timothy W Lovenberg, Ruggero Galici
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20210 (2011)
The role of 5-HT₇ receptor has been demonstrated in various animal models of mood disorders; however its function in cognition remains largely speculative. This study evaluates the effects of SB-269970, a selective 5-HT₇ antagonist, in a translat
Externí odkaz:
https://doaj.org/article/625bbaacd439475e85ab2b3777ebb702
Autor:
James A. Palmer, Natalie Welty, James R. Shoblock, Leah Aluisio, Nicholas I. Carruthers, Ian Fraser, Pascal Bonaventure, S. Timothy Motley, Timothy W. Lovenberg, Ruggero Galici, Kirsten L. Morton, Jamin D. Boggs
Publikováno v:
Psychopharmacology. 215:191-203
Orexin-1 receptor antagonists have been shown to block the reinforcing effects of drugs of abuse and food. However, whether blockade of orexin-2 receptor has similar effects has not been determined. We have recently described the in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfa317e6424220ebfe6fb5bc1300091
https://doi.org/10.1007/s00213-010-2127-x
https://doi.org/10.1007/s00213-010-2127-x
Autor:
Ruggero Galici, Amir H. Rezvani, Timothy W. Lovenberg, Leah Aluisio, Edward D. Levin, Natalie Welty, Pascal Bonaventure, Christine Dugovic, Jamin D. Boggs, S. Timothy Motley, Michael A. Letavic, Nicholas I. Carruthers, James R. Shoblock, Brian Lord, Ian Fraser
Publikováno v:
Psychopharmacology. 214:829-841
A few recent studies suggest that brain histamine levels and signaling via H(3) receptors play an important role in modulation of alcohol stimulation and reward in rodents.The present study characterized the effects of a novel, selective, and brain p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10df79c01db76937c8b84ea0062099d2
https://doi.org/10.1007/s00213-010-2092-4
https://doi.org/10.1007/s00213-010-2092-4
Autor:
Yi Nong, Tomas de Paulis, Ruggero Galici, P. Jeffrey Conn, Nicholas G. Echemendia, K. Hemstapat, Carrie K. Jones, Lilly C. Williams
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 318:173-185
Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide a novel approach for the treatment of anxiety disorders and schizophrenia. However, the relative contributions of the mG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938a7830da275316b9d68c6ccc4393c
https://doi.org/10.1124/jpet.106.102046
https://doi.org/10.1124/jpet.106.102046
Autor:
W. Anthony Owens, Rajkumar J. Sevak, Ruggero Galici, Xiaoying Chang, Martin A. Javors, Aurelio Galli, Charles P. France, Lynette C. Daws
Publikováno v:
Journal of Neurochemistry. 94:1402-1410
Insulin affects brain reward pathways and there is converging evidence that this occurs through insulin regulation of the dopamine (DA) transporter (DAT). In rats made hypoinsulinemic by fasting, synaptosomal DA uptake is reduced. Interestingly, [3H]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5999b1d35950de80647831db8ca14ac
https://doi.org/10.1111/j.1471-4159.2005.03289.x
https://doi.org/10.1111/j.1471-4159.2005.03289.x
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1181-1187
Recent studies suggest that agonists of group II metabotropic glutamate (mGlu) receptors (mGlu2/3) have potential utility as novel therapeutic agents for treatment of psychiatric disorders such as anxiety and schizophrenia. Agonists of mGlu2/3 recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0c1b8c48bffe486d44a74b93ab6a59
https://doi.org/10.1124/jpet.105.091074
https://doi.org/10.1124/jpet.105.091074
Autor:
Ruggero Galici, Aurelio Galli, David J. Jones, Teresa A. Sanchez, Christine Saunders, Alan Frazer, Georgianna G. Gould, Richard Z. Lin, Charles P. France
Publikováno v:
Neuroendocrinology. 77:132-140
The dopamine transporter (DAT) regulates extracellular dopamine DA levels and is an important site of action for amphetamine and cocaine. Amphetamine and cocaine increase extracellular levels of DA by acting on the DAT; thus, variations in DAT bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80fffc64fe221c37b23d1617123b1ed
https://doi.org/10.1159/000068650
https://doi.org/10.1159/000068650
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2719-2723
Abrupt termination of the treatment of humans with benzodiazepines (BDZs) leads to a rapid onset of discontinuation syndrome characterized by anxiety, muscle spasms, and occasionally convulsions. For this reason, it is recommended in clinical practic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca8381b82df766e6cf7a76df06ba00d
https://doi.org/10.1073/pnas.94.6.2719
https://doi.org/10.1073/pnas.94.6.2719
Autor:
Curt A. Dvorak, S. Timothy Motley, Timothy W. Lovenberg, Leah Aluisio, Diane Nepomuceno, Kirsten L. Morton, John R. Atack, Steve W. Sutton, Pascal Bonaventure, Nicholas I. Carruthers, Ian Fraser, Lisa Dvorak, Swanson Devin M, Natalie Welty, Ruggero Galici, James R. Shoblock, Brian Lord
Publikováno v:
Psychopharmacology. 208(2)
The lack of potent, selective, brain penetrant Y(2) receptor antagonists has hampered in vivo functional studies of this receptor.Here, we report the in vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f28510e95db447c14acfad885c2d99a
https://pubmed.ncbi.nlm.nih.gov/19953226
https://pubmed.ncbi.nlm.nih.gov/19953226