Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ruggero Dondi"'
Autor:
Elnaz Yaghini, Ruggero Dondi, Kunal M. Tewari, Marilena Loizidou, Ian M. Eggleston, Alexander J. MacRobert
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can s
Externí odkaz:
https://doaj.org/article/4f1101065e3c429892ad59ab68c9d579
Autor:
Jonathan R. Dilworth, Helena C. Quilter, Gabriele Kociok-Köhn, Rüdiger M. Exner, Sophia Sarpaki, Fernando Cortezon-Tamarit, Sofia I. Pascu, Philip A. Waghorn, Ruggero Dondi, Ian M. Eggleston, Valeria Ciaffaglione, Haobo Ge, Stanley W. Botchway, Samuel P. Godfrey
Publikováno v:
Bioconjugate Chemistry
Over the past decade, porphyrin derivatives have emerged as invaluable synthetic building blocks and theranostic kits for the delivery of cellular fluorescence imaging and photodynamic therapy. Tetraphenylporphyrin (TPP), its metal complexes, and rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::758379037a58e95d1c238a7b33b97dd1
http://europepmc.org/articles/PMC8299459
http://europepmc.org/articles/PMC8299459
Autor:
Ian M. Eggleston, Elnaz Yaghini, Ruggero Dondi, Kunal M. Tewari, Karen J. Edler, Marilena Loizidou, Alexander J. MacRobert
Publikováno v:
ECS Meeting Abstracts. :985-985
The conjugation of photosensitisers to proteins or targeting peptides is a well-established approach for enhancing solubility and tissue selectivity for both photodynamic therapy (PDT) of cancer and light-activated drug delivery. A key innovation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4415b03b32eb25ffe30dff56956bf845
https://doi.org/10.1149/ma2022-0114985mtgabs
https://doi.org/10.1149/ma2022-0114985mtgabs
Autor:
Kunal M. Tewari, Elnaz Yaghini, Charareh Pourzand, A. J. MacRobert, Ruggero Dondi, Ian M. Eggleston
Publikováno v:
Tewari, K M, Dondi, R, Yaghini, E, Pourzand, C, MacRobert, A J & Eggleston, I M 2021, ' Peptide-targeted dendrimeric prodrugs of 5-aminolevulinic acid : A novel approach towards enhanced accumulation of protoporphyrin IX for photodynamic therapy ', Bioorganic Chemistry, vol. 109, 104667 . https://doi.org/10.1016/j.bioorg.2021.104667
Photodynamic therapy (PDT) is a promising approach for the targeted treatment of cancer and various other human disorders. An effective, clinically approved approach in PDT involves the administration of 5-aminolevulinic acid (ALA) to generate elevat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee01693a97faa8102da17f8b5766a966
https://pubmed.ncbi.nlm.nih.gov/33611140
https://pubmed.ncbi.nlm.nih.gov/33611140
Autor:
Elnaz Yaghini, Karen J. Edler, Ruggero Dondi, Alexander J. MacRobert, Ian M. Eggleston, Marilena Loizidou
Publikováno v:
Nanoscale. 10:20366-20376
Endosomal entrapment is a key issue for the intracellular delivery of many nano-sized biotherapeutics to their cytosolic or nuclear targets. Photochemical internalisation (PCI) is a novel light-based solution that can be used to trigger the endosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::438125a22b080706190298577e16827f
https://doi.org/10.1039/c8nr04048f
https://doi.org/10.1039/c8nr04048f
Autor:
L. Wang, Ruggero Dondi, Ian M. Eggleston, Marilena Loizidou, Francesca Giuntini, A. J. MacRobert, Elnaz Yaghini, Kunal M. Tewari
Publikováno v:
Organic & Biomolecular Chemistry
Amphiphilic cell-penetrating peptide–porphyrin conjugates have been developed for application in light-based therapeutic techniques.
Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of biocon
Efficient syntheses of cell-penetrating peptide–porphyrin conjugates are described using a variety of biocon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fce615a52863af0292310adf0bd798b
https://doi.org/10.1039/c6ob02135b
https://doi.org/10.1039/c6ob02135b
Autor:
Alasdair W. Clark, Heba A. Kashmery, Glenn A. Burley, Ruggero Dondi, Paul M. Cullis, Andrew J. Fallows
Publikováno v:
European Journal of Inorganic Chemistry. 2014:4886-4895
This manuscript describes a one-pot method for the synthesis of size- and shape-selected silver nanoparticles (AgNPs) using Tollens' reagent [Ag(NH3)2OH] as the silver source. Sugar triazole ligands facilitate the formation of monodisperse AgNPs in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e0753d7f9cf8eb376698253c430e24
https://doi.org/10.1002/ejic.201402593
https://doi.org/10.1002/ejic.201402593
Publikováno v:
Small (Weinheim an Der Bergstrasse, Germany)
A mild, facile one-step synthetic strategy for the preparation of size- and shape-controlled silver nanoparticles (AgNPs) is presented. The high degree of size- and shape-control of these AgNPs is achieved by the use of triazole sugar ligands scaffol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa1a9da9a8ca36ca0b5a39688a9a9b3
http://europepmc.org/articles/PMC3818698
http://europepmc.org/articles/PMC3818698
Autor:
Duncan Graham, Glenn A. Burley, Samuel Mabbott, Ruggero Dondi, Alasdair W. Clark, Heba A. Kashmery, David G. Thompson
Publikováno v:
Chemical communications (Cambridge, England). 51(65)
Two advances in the development of a one-pot method to prepare silver nanoparticles (AgNPs) using the Tollens' reagent are described. First, a template-directed process of AgNP synthesis using resorcinol triazole ligands bearing two pendent galactose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8daf20d6db952c26cf66207cbfb60ac
https://pubmed.ncbi.nlm.nih.gov/26179948
https://pubmed.ncbi.nlm.nih.gov/26179948
Autor:
Alistair Taverner, Randall J. Mrsny, Ian M. Eggleston, Ruggero Dondi, Floriane Laurent, Nikoletta Fotaki, Siân-Eleri Owens, Khaled Almansour
Publikováno v:
Journal of Controlled Release
Taverner, A, Dondi, R, Almansour, K, Laurent, F, Owens, S-E, Eggleston, I M, Fotaki, N & Mrsny, R J 2015, ' Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation ', Journal of Controlled Release, vol. 210, pp. 189-197 . https://doi.org/10.1016/j.jconrel.2015.05.270
Taverner, A, Dondi, R, Almansour, K, Laurent, F, Owens, S-E, Eggleston, I M, Fotaki, N & Mrsny, R J 2015, ' Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation ', Journal of Controlled Release, vol. 210, pp. 189-197 . https://doi.org/10.1016/j.jconrel.2015.05.270
The intestinal epithelium functions to effectively restrict the causal uptake of luminal contents but has been demonstrated to transiently increase paracellular permeability properties to provide an additional entry route for dietary macromolecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2711402ee0f6d1dd6738453c4a9d862e
https://pubmed.ncbi.nlm.nih.gov/25980620
https://pubmed.ncbi.nlm.nih.gov/25980620