HIF1α-Dependent Induction of TFRC by a Combination of Intestinal Inflammation and Systemic Iron Deficiency in Inflammatory Bowel Disease

Autor: Raphael R. Fagundes, Arno R. Bourgonje, Shixian Hu, Ruggero Barbieri, Bernadien H. Jansen, Nienke Sinnema, Tjasso Blokzijl, Cormac T. Taylor, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-

Externí odkaz: https://doaj.org/article/e4a7a598a9e746c48a15192845949bc6

U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma

Autor: Sandra Vorlova, Gina Blahetek, Ruggero Barbieri, Yvonne Kerstan, Annabelle Rosa, Maja Bundalo, Manuel Egg, Elke Butt, Erik Henke, Lars Dölken, Roland Houben, Bastian Schilling, Utz Fischer, Florian Erhard, Alma Zernecke

Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of mammalian miRNAs are also located within intronic regions of protein-coding genes and are transcriptionally co-expressed with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3fa6794ad75c63929b52c2ce9853e14
https://doi.org/10.1101/2022.06.01.479622

Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis

Autor: Henkjan J. Verkade, Cleo C. van Diemen, Sjoukje-Marije Haisma, Obbe F. Norbruis, Barbara A. E. de Koning, Rinse K. Weersma, Bart G. P. Koot, Jukka Koskela, Marijn C. Visschedijk, Christine Stevens, Manuel A. Rivas, Tim G. J. de Meij, Ruggero Barbieri, Eleonora A. M. Festen, Mark J. Daly, Victorien M. Wolters, Patrick F. van Rheenen, Maria E. Joosse, Ramnik J. Xavier, Dianne Jansen

Publikováno v: Liver International. Wiley
Liver international, 41(5), 1044-1057. Wiley-Blackwell
Liver International, 41(5), 1044-1057. Wiley-Blackwell Publishing Ltd
Haisma, S-M, Weersma, R K, Joosse, M E, de Koning, B A E, de Meij, T, Koot, B G P, Wolters, V, Norbruis, O, Daly, M J, Stevens, C, Xavier, R J, Koskela, J, Rivas, M A, Visschedijk, M C, Verkade, H J, Barbieri, R, Jansen, D B H, Festen, E A M, van Rheenen, P F & van Diemen, C C 2021, ' Exome sequencing in patient-parent trios suggests new candidate genes for early-onset primary sclerosing cholangitis ', Liver International, vol. 41, no. 5, pp. 1044-1057 . https://doi.org/10.1111/liv.14831
Liver International
Liver International, 41(5), 1044-1057. Wiley-Blackwell

BACKGROUND & AIMS: Primary sclerosing cholangitis (PSC) is a rare bile duct disease strongly associated with inflammatory bowel disease (IBD). Whole-exome sequencing (WES) has contributed to understanding the molecular basis of very early-onset IBD,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e15a5798fae6fd996d88d4f01b0b0a
https://research.rug.nl/en/publications/b71feb2a-c6ae-4606-b1b4-5a2d03b6fdb0

Correction to

Autor: Morris A. Swertz, A Vich Vila, Valerie Collij, Floris Imhann, K. W. J. Van der Sloot, K. J. van der Velde, Ruggero Barbieri, Marijn C. Visschedijk, Rinse K. Weersma, H. M. van Dullemen, Rudi Alberts, Lieke M. Spekhorst, Vera Peters, Eleonora A. M. Festen, Gerard Dijkstra, Michiel Voskuil

Publikováno v: BMC Gastroenterology
BMC Gastroenterology, Vol 19, Iss 1, Pp 1-1 (2019)

Background Inflammatory bowel disease (IBD) is a chronic complex disease of the gastrointestinal tract. Patients with IBD can experience a wide range of symptoms, but the pathophysiological mechanisms that cause these individual differences in clinic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d318c378e72a183b1035d26b3a7adb54
https://doi.org/10.1186/s12876-019-0938-8

MOLGENIS research: advanced bioinformatics data software for non-bioinformaticians

Autor: Bart Charbon, Floris Imhann, Mark de Haan, K. Joeri van der Velde, Rinse K. Weersma, Fleur Kelpin, Ruggero Barbieri, Sido Haakma, Morris A. Swertz, Eleonora A. M. Festen, Dennis Hendriksen, Tommy de Boer, Rudi Alberts, Gert-Jan M. van de Geijn, Connor Stroomberg, Chao Pang, David van Enckevort, Salome Scholtens, Mariska Slofstra

Publikováno v: Bioinformatics
Bioinformatics (Oxford, England), 35(6), 1076-1078. Oxford University Press

Motivation The volume and complexity of biological data increases rapidly. Many clinical professionals and biomedical researchers without a bioinformatics background are generating big ’-omics’ data, but do not always have the tools to manage, pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4709459e8dc1f9a07d92d36791f11631
https://pubmed.ncbi.nlm.nih.gov/30165396