Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Rugang, Zhang"'
Autor:
Chen Wang, Hideki Tanizawa, Connor Hill, Aaron Havas, Qiang Zhang, Liping Liao, Xue Hao, Xue Lei, Lu Wang, Hao Nie, Yuan Qi, Bin Tian, Alessandro Gardini, Andrew V. Kossenkov, Aaron Goldman, Shelley L. Berger, Ken-ichi Noma, Peter D. Adams, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract METTL3 is the catalytic subunit of the methyltransferase complex, which mediates m6A modification to regulate gene expression. In addition, METTL3 regulates transcription in an enzymatic activity-independent manner by driving changes in high
Externí odkaz:
https://doaj.org/article/510df8c88f934aa994ca58141deaa581
Autor:
Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J. Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T. Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it’s unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored. Here, we show tha
Externí odkaz:
https://doaj.org/article/f6c6df012ec140a7a4fd2deb6a11201f
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/07f6269bbc404c9d86382e706a5b365b
Autor:
Nan Zhang, Toshitha Kannan, Andrew Kossenkov, Taito Miyamoto, Brennah Murphy, Bryan Manning, Daniel Claiborne, Rugang Zhang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/08afa674686d414ba293995783f8d990
Autor:
Abdurrahman Elbasir, Ying Ye, Daniel E. Schäffer, Xue Hao, Jayamanna Wickramasinghe, Konstantinos Tsingas, Paul M. Lieberman, Qi Long, Quaid Morris, Rugang Zhang, Alejandro A. Schäffer, Noam Auslander
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here, Elbasir et al. develop viRNAtrap, a deep learning approach for detection of viruses from tumor RNA sequencing data, which they showcase on an RNA dataset of different cancer types, revealing tumor expression of divergent viruses that had not be
Externí odkaz:
https://doaj.org/article/421e42058eca41a19dcd684464f627fa
Publikováno v:
Molecular Oncology, Vol 16, Iss 18, Pp 3319-3332 (2022)
Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and grow
Externí odkaz:
https://doaj.org/article/2930a253d0f34aad9cb9a2f9fa3f44d6
Autor:
Devivasha Bordoloi, Pratik S. Bhojnagarwala, Alfredo Perales-Puchalt, Abhijeet J. Kulkarni, Xizhou Zhu, Kevin Liaw, Ryan P. O’Connell, Daniel H. Park, Daniel W. Kulp, Rugang Zhang, David B. Weiner
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor cells and
Externí odkaz:
https://doaj.org/article/a607704c926640839bde5206f6333f01
Autor:
Jianhuang Lin, Heng Liu, Takeshi Fukumoto, Joseph Zundell, Qingqing Yan, Chih-Hang Anthony Tang, Shuai Wu, Wei Zhou, Dajiang Guo, Sergey Karakashev, Chih-Chi Andrew Hu, Kavitha Sarma, Andrew V. Kossenkov, Rugang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The unfolded protein response (UPR) promotes cell survival in cancers with hyperactive ER stress response. Here the authors show that CARM1, an arginine methyltransferase, controls the IRE1α/XBP1 pathway of the UPR and the inhibition of this pathway
Externí odkaz:
https://doaj.org/article/30c7f569e8f14f29b50078b914b06fde
Autor:
Hyoung Kim, Haineng Xu, Erin George, Dorothy Hallberg, Sushil Kumar, Veena Jagannathan, Sergey Medvedev, Yasuto Kinose, Kyle Devins, Priyanka Verma, Kevin Ly, Yifan Wang, Roger A. Greenberg, Lauren Schwartz, Neil Johnson, Robert B. Scharpf, Gordon B. Mills, Rugang Zhang, Victor E. Velculescu, Eric J. Brown, Fiona Simpkins
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Patients with ovarium cancer frequently develop resistance to platinum chemotherapy and PARP inhibitors (PARPi). Here, the authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PARPi and platinum resistant
Externí odkaz:
https://doaj.org/article/cc35bbdbfeb9477db7745da1954cd683
Autor:
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inf
Externí odkaz:
https://doaj.org/article/f687034dd13c48c997ad226023ef1a47