Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy

Autor: Jessica R. Terrill, Marisa N. Duong, Rufus Turner, Caroline Le Guiner, Amber Boyatzis, Anthony J. Kettle, Miranda D. Grounds, Peter G. Arthur

Publikováno v: Redox Biology, Vol 9, Iss C, Pp 276-286 (2016)

Duchenne Muscular Dystrophy (DMD) is a fatal skeletal muscle wasting disease presenting with excessive myofibre necrosis and increased inflammation and oxidative stress. In the mdx mouse model of DMD, homeostasis of the amino acid taurine is altered,

Externí odkaz: https://doaj.org/article/29ad5a16f08b4faf8c2a2376d98d4d97

Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites

Autor: Kara J. Filbey, Anthony J. Kettle, Rufus Turner, Ramon M. Eichenberger, Paul R. Giacomin, Jodie Chandler, Graham Le Gros, Mali Camberis

Publikováno v: Filbey, K, Camberis, M, Chandler, J, Turner, R, Kettle, A, Eichenberger, R, Giacomin, P & Le Gros, G 2018, ' Intestinal helminth infection promotes IL-5-and CD4+ T cell-dependent immunity in the lung against migrating parasites. ', Mucosal Immunology . https://doi.org/10.1038/s41385-018-0102-8

The ability of helminths to manipulate the immune system of their hosts to ensure their own survival is often credited with affecting responses to other pathogens. We undertook co-infection experiments in mice to determine how infection with the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f554e3ad95a3fb2e1b16d12e3ba000fc
https://doi.org/10.1038/s41385-018-0102-8

Intestinal helminth infection promotes IL-5- and CD4

Autor: Kara J, Filbey, Mali, Camberis, Jodie, Chandler, Rufus, Turner, Anthony J, Kettle, Ramon M, Eichenberger, Paul, Giacomin, Graham, Le Gros

Publikováno v: Mucosal immunology. 12(2)

The ability of helminths to manipulate the immune system of their hosts to ensure their own survival is often credited with affecting responses to other pathogens. We undertook co-infection experiments in mice to determine how infection with the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55613139f4196ebeeb11401ace318a82
https://pubmed.ncbi.nlm.nih.gov/30401814

Oxidation of calprotectin by hypochlorous acid prevents chelation of essential metal ions and allows bacterial growth: Relevance to infections in cystic fibrosis

Autor: Nicholas J. Magon, Peter D. Sly, Richard B. Gearry, Mark B. Hampton, Rufus Turner, Anthony J. Kettle

Publikováno v: Free Radical Biology and Medicine. 86:133-144

Calprotectin provides nutritional immunity by sequestering manganese and zinc ions. It is abundant in the lungs of patients with cystic fibrosis but fails to prevent their recurrent infections. Calprotectin is a major protein of neutrophils and compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3599a3881a96aeb43d7ebaa7233ebd98
https://doi.org/10.1016/j.freeradbiomed.2015.05.022

Measuring chlorine bleach in biology and medicine

Autor: Anna L.P. Chapman, Amelia M. Albrett, Louisa V. Forbes, Rufus Turner, Anthony J. Kettle, Nina Dickerhof, Irada Khalilova

Publikováno v: Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:781-793

Background Chlorine bleach, or hypochlorous acid, is the most reactive two-electron oxidant produced in appreciable amounts in our bodies. Neutrophils are the main source of hypochlorous acid. These champions of the innate immune system use it to fig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b39cdcf738786d06ed14f3e21e30c4
https://doi.org/10.1016/j.bbagen.2013.07.004