Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Rufus S. Day"'
Autor:
Junji Miyakoshi, Sibghat-Ullah Lari, Hiraku Takebe, David Murray, Aghdass Rasouli-Nia, Shigeru Tsunoda, Rufus S. Day, Kelly Dobler, James Meservy
Publikováno v:
Photochemistry and Photobiology. 70:217-227
An ongoing study in our laboratories is to examine the relationship of DNA repair defects to human cancer. Our underlying hypothesis has been that human tumors may arise that lack interesting DNA repair pathways if these pathways are important in pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5473bdc7ca2ee673848fa3ef483a09fa
https://doi.org/10.1111/j.1751-1097.1999.tb07992.x
https://doi.org/10.1111/j.1751-1097.1999.tb07992.x
Publikováno v:
Journal of Biological Chemistry. 271:20088-20095
The biological consequences of O6-methylguanine (m6G) in DNA are well recognized. When template m6G is encountered by DNA polymerases, replication is hindered and trans-lesion replication results in the preferential incorporation of dTMP opposite tem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabf8800cd3478deb644c2ea90f5f581
https://doi.org/10.1074/jbc.271.33.20088
https://doi.org/10.1074/jbc.271.33.20088
Autor:
Rufus S. Day, Sibghat-Ullah
Publikováno v:
Biochemistry. 34:6869-6875
Cell-free extract from human tumor cell line A1235 (lacking O6-methylguanine-DNA methyltransferase) was employed to compare incision at G:T base mispairs with that at O6-methylguanine (m6G):T pairs at two different sites (sites 20 and 25) in 45-bp he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057c4af2c3732b77d083d7fe62e89d2f
https://doi.org/10.1021/bi00020a034
https://doi.org/10.1021/bi00020a034
Publikováno v:
Journal of Radiation Research. 36:239-247
Effects of the introduction of the Simian virus 40 T-antigen (SV40 T-Ag) gene to cultured human cells were examined in relation to radiosensitivity. Two relatively radioresistant tumor cell lines (T98 and G361) became significantly radiosensitive aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b56c42cddd7c9b3eb834711f3f4c53
https://doi.org/10.1269/jrr.36.239
https://doi.org/10.1269/jrr.36.239
Autor:
Rufus S. Day, Dominic A. Scudiero, Sharon A. Meyer, Chuck H. J. Ziolkowski, Michael R. Mattern
Publikováno v:
Carcinogenesis. 1(1)
We have previously identified four human astrocytoma cell strains as defective in the repair of N-methyl-N' -nitro-N-nitrosoguanidine (MNNG) damaged adenovirus 5. We now show that two of these strains (the only two tested), in comparison to other tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5140008be77e766f9e1438775cd3e9e
https://pubmed.ncbi.nlm.nih.gov/22282976
https://pubmed.ncbi.nlm.nih.gov/22282976
Autor:
Sean V. Tavtigian, Jane Weaver-Feldhaus, Keith D Harshman, Bruce E. Johnson, Alexander Kamb, Qingyun Liu, Mark H. Skolnick, Nelleke A. Gruis, Elisabeth Stockert, Rufus S. Day
Publikováno v:
Science. 264:436-440
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region contained a gene, Multiple Tumor Suppressor 1 (MTS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e58bcad11c36232f8890012d1b22bba
https://doi.org/10.1126/science.8153634
https://doi.org/10.1126/science.8153634
Publikováno v:
Mutation Research/DNA Repair. 314:99-113
O6-Methylguanine (m6G) is an altered base produced in DNA by SN1 methylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). This lesion is repaired by the protein O6-methylguanine-DNA methyltransferase (MGMT) in normal human cell lines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9722264f4c8a98d4c2399380efac7728
https://doi.org/10.1016/0921-8777(94)90074-4
https://doi.org/10.1016/0921-8777(94)90074-4
Autor:
Sibghat-Ullah, Rufus S. Day
Publikováno v:
Biochemistry. 31:7998-8008
Human cell-free extracts were used to detect activities specifically incising O6-methylguanine (m6G) paired with C or T in DNA. A 45-bp double-stranded DNA containing one m6G across from a T (m6G:T) was the test substrate. Extracts from glioblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1114c47aa428260a424fa6d5fe2668
https://doi.org/10.1021/bi00149a034
https://doi.org/10.1021/bi00149a034
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 22:765-768
Two tumor cell lines were established from each of three human malignant glioma biopsy specimens (M059, M067, M071) and sensitivity to treatment with radiation or chemotherapeutic agents (BCNU, nitrogen mustard) was determined. The effects of recombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3164b41fc51c6c5e482d4bfd6036440f
https://doi.org/10.1016/0360-3016(92)90520-r
https://doi.org/10.1016/0360-3016(92)90520-r
Publikováno v:
Mutation Research/DNA Repair. 254:153-160
With increasing passage in culture, the human fibroblast cell strain GM11 lost the Mer+ phenotype (the ability to support the growth of adenovirus 5 damaged prior to infection by MNNG). All of 46 embryonic strains prepared either from various organs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4597f0f57f12050227100eeb390da6b
https://doi.org/10.1016/0921-8777(91)90006-b
https://doi.org/10.1016/0921-8777(91)90006-b