Výsledky vyhledávání - "Rufus M. Williamson"

Potent, Orally Active, Competitive N-Methyl-D-aspartate (NMDA) Receptor Antagonists Are Substrates for a Neutral Amino Acid Uptake System in Chinese Hamster Ovary Cells

Autor: Christopher F. Bigge, Jia-He Li, Susan A. Borosky, Rufus M. Williamson, Daniel F. Ortwine, Mark G. Vartanian

Publikováno v: Journal of Medicinal Chemistry. 38:1955-1965

A series of enantiomerically pure (phosphonomethyl)-substituted phenylalanine derivatives related to SDZ EAB 515 (1) were prepared as competitive N-methyl-D-aspartate (NMDA) receptor antagonists. Unlike most known competitive NMDA antagonists, analog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09fa37f51b06607d4543f8a0603d7df
https://doi.org/10.1021/jm00011a015

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Sequence and structural similarities between the leucine-specific binding protein and leucyl-tRNA synthetase of Escherichia coli

Autor: Rufus M. Williamson, Dale L. Oxender

Publikováno v: Proceedings of the National Academy of Sciences. 87:4561-4565

A role for the leucyl-tRNA synthetase (EC 6.1.1.4) has been established for regulating the transport of leucine across the inner membrane of Escherichia coli by the leucine, isoleucine, valine (LIV-I) transport system. This transport system is mediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c757ca4e9add0ada574375e5040b0e
https://doi.org/10.1073/pnas.87.12.4561

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Improved intestinal transport of PD 158473, an N-methyl-D-aspartate (NMDA) antagonist, by involvement of multiple transporters

Autor: Christopher F. Bigge, Gordon L. Amidon, Rufus M. Williamson, Doo Man Oh, Narayanan Surendran, Hyo Kyung Han, Barbra H. Stewart

Publikováno v: Journal of pharmaceutical sciences. 91(12)

The objective of this research was to determine the characteristics of intestinal transport of PD 0158473 using in vitro Caco-2 cells as well as in situ single-pass rat intestinal perfusion models. Because apical (AP)-to-basolateral (BL) transport wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad94f4dc66523b1fa4ce7857c5d0603
https://pubmed.ncbi.nlm.nih.gov/12434401

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Information theory analysis of the relationship between primary sequence structure and ligand recognition among a class of facilitated transporters

Autor: Rufus M. Williamson

Publikováno v: Journal of theoretical biology. 174(2)

Determining how specificity for a given ligand occurs among sequence and structurally related transporters is a fundamental problem in elucidating facilitated transport. It is likely that the specificity of a transporter for a ligand is defined by th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5003412d5a5cc71fcda30f4d14e7a6c3
https://pubmed.ncbi.nlm.nih.gov/7643612

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Molecular Biological Approaches for Amino Acid Transport

Autor: Dale L. Oxender, Rufus M. Williamson, Ti Zhi Su

Publikováno v: Mammalian Amino Acid Transport ISBN: 9781489911636

While enormous progress has been made in the elucidation of the molecular basis of amino acid transport in bacteria and lower eukaryotes, an understanding of the molecular principles that underlie mammalian amino acid transport is in its infancy. Inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::741b3810337e51ea2d7cda6259d4d104
https://doi.org/10.1007/978-1-4899-1161-2_4

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