Detection of alpha‐synuclein conformational variants from gastro‐intestinal biopsy tissue as a potential biomarker for Parkinson's disease.

Autor: Ruffmann, C.¹, Bengoa‐Vergniory, N.², Poggiolini, I.¹, Ritchie, D.³, Hu, M. T.¹, Alegre‐Abarrategui, J.², Parkkinen, L.¹ laura.parkkinen@ndcn.ox.ac.uk

Publikováno v: Neuropathology & Applied Neurobiology. Dec2018, Vol. 44 Issue 7, p722-736. 15p.

Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases.

Autor: Ruffmann, C.^1,2, Calboli, F. C. F.¹, Bravi, I.³, Gveric, D.³, Curry, L. K.¹, Smith, A.^4,5, Pavlou, S.^4,6, Buxton, J. L.⁷, Blakemore, A. I. F.⁷, Takousis, P.¹, Molloy, S.³, Piccini, P.³, Dexter, D. T.³, Roncaroli, F.⁸, Gentleman, S. M.³, Middleton, L. T.¹

Publikováno v: Neuropathology & Applied Neurobiology. Aug2016, Vol. 42 Issue 5, p436-450. 15p.

Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells

Autor: Smith, A, Depp, C, Ryan, B, Johnston, G, Alegre-Abarrategui, J, Evetts, S, Rolinski, M, Baig, F, Ruffmann, C, Simon, A, Hu, M, Wade-Martins, R

Publikováno v: Smith, A M, Depp, C, Ryan, B J, Johnston, G I, Alegre-Abarrategui, J, Evetts, S, Rolinski, M, Baig, F, Ruffmann, C, Simon, A K, Hu, M T M & Wade-Martins, R 2018, ' Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells ', Movement Disorders, vol. 33, no. 10, pp. 1580-1590 . https://doi.org/10.1002/mds.104

Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To investigate disease processes in accessible patient cells, we studied peripheral blood mononuclear c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::41fc3c393042b5f4fe011fddbb07ed3d
http://hdl.handle.net/10044/1/66013

Atypical tauopathy in a patient with LRRK2-G2019S mutation and tremor-dominant Parkinsonism.

Autor: Ruffmann, C.¹, Giaccone, G.², Canesi, M.¹, Bramerio, M.³, Goldwurm, S.¹, Gambacorta, M.³, Rossi, G.², Tagliavini, F.², Pezzoli, G.¹

Publikováno v: Neuropathology & Applied Neurobiology. Jun2012, Vol. 38 Issue 4, p382-386. 5p. 2 Color Photographs, 1 Chart.

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Autor: Fairfoul G, Li, Mcguire, Pal S, James Ironside, Neumann J, Christie S, Joachim C, Esiri M, Sg, Evetts, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Mt, Hu, Parkkinen L, Aj, Green

Publikováno v: Fairfoul, G, McGuire, L I, Pal, S, Ironside, J W, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A J E 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology, vol. 3, no. 10, pp. 812-818 . https://doi.org/10.1002/acn3.338
Fairfoul, G, McGuire, L I, Pal, S, Ironside, J, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology . https://doi.org/10.1002/acn3.338
Europe PubMed Central

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::351ee8fb8496eef3273960e63c8cab81
http://ora.ox.ac.uk/objects/uuid: