Predictors of motor complications in early Parkinson's disease: A prospective cohort study

Autor: Kelly, MJ, Lawton, MA, Baig, F, Ruffmann, C, Barber, TR, Lo, C, Klein, JC, Ben-Shlomo, Y, Hu, MT

Publikováno v: Movement Disorders

Objective The objective of this study was to identify clinical predictors of motor complications (dyskinesia and motor fluctuations) of levodopa in a prospectively recruited PD cohort using longitudinal analysis. Methods An inception cohort (Oxford D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::605e6681cacbd1d5eb5276858acd2390
http://europepmc.org/articles/PMC6771533

Predicting motor, cognitive and functional impairment in Parkinson's

Autor: Lo, C, Arora, S, Baig, F, Lawton, M, El Mouden, C, Barber, T, Ruffmann, C, Klein, J, Brown, P, Ben‐Shlomo, Y, Vos, M, Hu, M

Objective We recently demonstrated that 998 features derived from a simple 7‐minute smartphone test could distinguish between controls, people with Parkinson's and people with idiopathic Rapid Eye Movement sleep behavior disorder, with mean sensiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a1ff438aaf4fdfa2a92f90388fff6752
https://ora.ox.ac.uk/objects/uuid:360725c0-cd43-4807-994b-1cf1eaa1a156

Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies

Autor: Fairfoul G, Li, Mcguire, Pal S, James Ironside, Neumann J, Christie S, Joachim C, Esiri M, Sg, Evetts, Rolinski M, Baig F, Ruffmann C, Wade-Martins R, Mt, Hu, Parkkinen L, Aj, Green

Publikováno v: Fairfoul, G, McGuire, L I, Pal, S, Ironside, J W, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A J E 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology, vol. 3, no. 10, pp. 812-818 . https://doi.org/10.1002/acn3.338
Fairfoul, G, McGuire, L I, Pal, S, Ironside, J, Neumann, J, Christie, S, Joachim, C, Esiri, M, Evetts, S G, Rolinski, M, Baig, F, Ruffmann, C, Wade-Martins, R, Hu, M T M, Parkkinen, L & Green, A 2016, ' Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies ', Annals of Clinical and Translational Neurology . https://doi.org/10.1002/acn3.338
Europe PubMed Central

We have developed a novel real-time quaking-induced conversion RT-QuIC-based assay to detect alpha-synuclein aggregation in brain and cerebrospinal fluid from dementia with Lewy bodies and Parkinson's disease patients. This assay can detect alpha-syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::351ee8fb8496eef3273960e63c8cab81
http://ora.ox.ac.uk/objects/uuid:

Cortical involvement in early Parkinson's disease: evidence from multimodal MRI

Autor: Klein, J, Rolinski, M, Griffanti, L, Szewczyk-Krolikowski, K, Baig, F, Ruffmann, C, Groves, A, Menke, R, Mackay, C, Hu, M

MRI studies in early Parkinson’s disease (PD) have shown promise in the detection of disease-related brain changes in vivo in the white and deep grey matter. While neuropsychology points to early cortical dysfunction even in early PD, MRI data on c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::f97acb56f8e588d2f81d6da4336ffdf9
https://doi.org/10.1111/ene.13366

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