Pharmacological inhibition of macrophage triglyceride biosynthesis pathways does not improve Mycobacterium tuberculosis control in infected mice.

Autor: Ruelas Castillo J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Guerrini V; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Quijada D; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Karanika S; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Neupane P; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Urbanowski ME; The Internal Medicine Residency Program of the National Capital Consortium at Walter Reed National Military Medical Center. Bethesda, MD, United States., Shenkoya B; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, United States., Harris H; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Garcia A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Yilma A; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Annunziata H; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Khan R; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Gopalakrishnan M; Center for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD, United States., Gennaro ML; Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States., Karakousis PC; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis.

Autor: Karanika S; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Gordy JT; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Neupane P; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Karantanos T; Division of Hematological Malignancies, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University Hospital, Baltimore, MD, United States., Ruelas Castillo J; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Quijada D; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Comstock K; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Sandhu AK; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Kapoor AR; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Hui Y; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Ayeh SK; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Tasneen R; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Krug S; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Danchik C; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States., Wang T; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Schill C; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Markham RB; Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Karakousis PC; Division of Infectious Diseases, Department of Medicine, The Johns Hopkins Hospital, Baltimore, MD, United States.; W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Sep 16; Vol. 13, pp. 972266. Date of Electronic Publication: 2022 Sep 16 (Print Publication: 2022).

Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model.

Autor: Dhakal S; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ruiz-Bedoya CA; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Zhou R; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Creisher PS; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Villano JS; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Littlefield K; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ruelas Castillo J; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Marinho P; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Jedlicka AE; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Ordonez AA; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Bahr M; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Majewska N; Advanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7, Baltimore, Maryland, USA., Betenbaugh MJ; Advanced Mammalian Biomanufacturing Innovation Center, Department of Chemical and Biomolecular Engineering, Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7, Baltimore, Maryland, USA., Flavahan K; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Mueller ARL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA., Looney MM; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Quijada D; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Mota F; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Beck SE; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Brockhurst J; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Braxton AM; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Castell N; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Stover M; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., D'Alessio FR; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Metcalf Pate KA; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Karakousis PC; Department of Medicine, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Mankowski JL; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Pekosz A; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.; Department of Molecular and Comparative Pathobiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA., Jain SK; Department of Pediatrics, The Johns Hopkins Universitygrid.21107.35grid.471401.7grid.21107.35grid.471401.7grid.21107.35grid.471401.7 School of Medicine, Baltimore, Maryland, USA., Klein SL; W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Publikováno v: MBio [mBio] 2021 Aug 31; Vol. 12 (4), pp. e0097421. Date of Electronic Publication: 2021 Jul 13.

Higher Serum Cholesterol Levels Are Associated With Reduced Systemic Inflammation and Mortality During Tuberculosis Treatment Independent of Body Mass Index.

Autor: Chidambaram V; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States., Zhou L; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States., Ruelas Castillo J; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States., Kumar A; Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States., Ayeh SK; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States., Gupte A; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States., Wang JY; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Karakousis PC; Division of Infectious Diseases, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, United States.; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.

Publikováno v: Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2021 Jun 22; Vol. 8, pp. 696517. Date of Electronic Publication: 2021 Jun 22 (Print Publication: 2021).

Horizontal transmission and recombination maintain forever young bacterial symbiont genomes.

Autor: Russell SL; Department of Molecular Cellular and Developmental Biology. University of California Santa Cruz, Santa Cruz, California, United States of America.; Department of Biomolecular Engineering. University of California Santa Cruz, Santa Cruz, California, United States of America., Pepper-Tunick E; Department of Biomolecular Engineering. University of California Santa Cruz, Santa Cruz, California, United States of America.; Genomics Institute, University of California, Santa Cruz, California, United States of America., Svedberg J; Department of Biomolecular Engineering. University of California Santa Cruz, Santa Cruz, California, United States of America.; Genomics Institute, University of California, Santa Cruz, California, United States of America., Byrne A; Department of Molecular Cellular and Developmental Biology. University of California Santa Cruz, Santa Cruz, California, United States of America., Ruelas Castillo J; Department of Molecular Cellular and Developmental Biology. University of California Santa Cruz, Santa Cruz, California, United States of America., Vollmers C; Department of Biomolecular Engineering. University of California Santa Cruz, Santa Cruz, California, United States of America.; Genomics Institute, University of California, Santa Cruz, California, United States of America., Beinart RA; Graduate School of Oceanography. University of Rhode Island, Narragansett, Rhode Island, United States of America., Corbett-Detig R; Department of Biomolecular Engineering. University of California Santa Cruz, Santa Cruz, California, United States of America.; Genomics Institute, University of California, Santa Cruz, California, United States of America.

Publikováno v: PLoS genetics [PLoS Genet] 2020 Aug 25; Vol. 16 (8), pp. e1008935. Date of Electronic Publication: 2020 Aug 25 (Print Publication: 2020).