Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ruediger Spitz"'
Autor:
A A Hombach, Benedikt Brors, Thorsten Simon, Ruth Volland, Barbara Hero, Matthias Fischer, Frank Berthold, Ruediger Spitz, Marc Zapatka, Monika Ortmann, André Oberthuer, Jessica Theissen, Falk Hertwig
Publikováno v:
Genes, Chromosomes and Cancer. 53:639-649
The prognostic relevance of chromosome 17 gain in neuroblastoma is still discussed. This investigation specifies the frequency, type, size, and transcriptional relevance in a large patient cohort. Primary tumor material of 202 patients was analyzed u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b8f56639eabd2a62cad140fc0ca2ca
https://doi.org/10.1002/gcc.22174
https://doi.org/10.1002/gcc.22174
Publikováno v:
Clinical Cancer Research. 12:3368-3373
Purpose: To improve risk prediction in neuroblastoma and to specify the type of a possible relapse, alterations in the long arm of chromosome 11 were analyzed. Experimental Design: A representative cohort of 611 neuroblastomas was investigated for de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015b3e82e7d1472e164dd0c970456935
https://doi.org/10.1158/1078-0432.ccr-05-2495
https://doi.org/10.1158/1078-0432.ccr-05-2495
Autor:
Marc Boensch, André Oberthuer, Matthias Skowron, Ruediger Spitz, Matthias Fischer, Joern Oestreich, Frank Berthold
Publikováno v:
Diagnostic Molecular Pathology. 14:177-182
Amplification of the oncogene MYCN as well as deletions in 1p and 11q are important prognostic and in part therapy-stratifying factors in human neuroblastoma. Due to the increasing clinical relevance of these molecular markers, accurate and fast asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e5640f483a8398affd68dba394145a
https://doi.org/10.1097/01.pas.0000176767.10800.17
https://doi.org/10.1097/01.pas.0000176767.10800.17
Autor:
Karen Ernestus, Ruediger Spitz, Manfred Schwab, Frank Westermann, Frank Berthold, Barbara Hero
Publikováno v:
Genes, Chromosomes and Cancer. 34:299-305
Chromosomal alterations in 1p36 were investigated in 196 neuroblastoma tumors using fluorescence in situ hybridization. Additionally, by using the same technique, it was determined whether MYCN was amplified in 149 of these. The most frequent finding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48c082e095488cac2a2573809747e44
https://doi.org/10.1002/gcc.10070
https://doi.org/10.1002/gcc.10070
Autor:
Jessica, Theissen, Andre, Oberthuer, Anja, Hombach, Ruth, Volland, Falk, Hertwig, Matthias, Fischer, Ruediger, Spitz, Marc, Zapatka, Benedikt, Brors, Monika, Ortmann, Thorsten, Simon, Barbara, Hero, Frank, Berthold
Publikováno v:
Genes, chromosomescancer. 53(8)
The prognostic relevance of chromosome 17 gain in neuroblastoma is still discussed. This investigation specifies the frequency, type, size, and transcriptional relevance in a large patient cohort. Primary tumor material of 202 patients was analyzed u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1d1a2560d7d87e123f98259b2cb94d79
https://pubmed.ncbi.nlm.nih.gov/24737690
https://pubmed.ncbi.nlm.nih.gov/24737690
Autor:
A Hombach, Barbara Hero, Frank Berthold, J Theißen, M Fischer, Ruediger Spitz, André Oberthuer
Publikováno v:
Klinische Pädiatrie. 222
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26d753a28a807a4484208a5eb1abc0b2
https://doi.org/10.1055/s-0030-1254474
https://doi.org/10.1055/s-0030-1254474
Autor:
Tobias Bauer, Benedikt Brors, Rainer König, Roland Eils, M Fischer, Frank Westermann, Frank Berthold, Ruediger Spitz, Barbara Hero, Andre Oberthur, Mathias Ehrich, Jessica Theissen
Publikováno v:
Oncogene. 29(6)
Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ee64eae46d29a1ae4fcc64562ef991c
https://pubmed.ncbi.nlm.nih.gov/19901960
https://pubmed.ncbi.nlm.nih.gov/19901960
Autor:
Manfred Schwab, Holger Christiansen, Frank Berthold, Felix Niggli, Frank Westermann, David R. Betts, Barbara Hero, Thorsten Simon, Freimut H. Schilling, Jessica Theissen, Sabine Stegmaier, Marc Boensch, Ruediger Spitz
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 15(6)
Purpose: MYCN amplification is an important therapy-stratifying marker in neuroblastoma. Fluorescence in situ hybridization with signal detection on the single-cell level allows a critical judgement of MYCN intratumoral heterogeneity. Experimental De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f8da1f46cbec2f5f5c8589732b2374
https://pubmed.ncbi.nlm.nih.gov/19276282
https://pubmed.ncbi.nlm.nih.gov/19276282
Publikováno v:
Klinische Padiatrie. 220(3)
The pediatric tumor neuroblastoma is a heterogeneous disease: Patients' clinical courses can range from spontaneous regression to fatal progression of the disease. Accordingly, treatment protocols vary from "wait and see" approaches to intensive mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1c37f87e3a84b33576a972334679f0
https://pubmed.ncbi.nlm.nih.gov/18478485
https://pubmed.ncbi.nlm.nih.gov/18478485
Autor:
Astrid Gnekow, Karen Ernestus, Ruediger Spitz, Frank Berthold, Hans-Guenther Scheel-Walter, Dirk Schwabe, Freimut H. Schilling, Barbara Hero, Gabriele Benz-Bohm, Thorsten Simon
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 26(9)
Purpose The excellent prognosis of localized neuroblastoma in infants, the overdiagnosis observed in neuroblastoma screening studies, and several case reports of regression of localized neuroblastoma prompted us to initiate a prospective cooperative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b532f189445f5f3a9f3422ff40f879e
https://pubmed.ncbi.nlm.nih.gov/18349403
https://pubmed.ncbi.nlm.nih.gov/18349403