The signature of liver cancer in immune cells DNA methylation

Autor: Yonghong Zhang, Sophie Petropoulos, Jinhua Liu, David Cheishvili, Rudy Zhou, Sergiy Dymov, Kang Li, Ning Li, Moshe Szyf

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-17 (2018)

Abstract Background The idea that changes to the host immune system are critical for cancer progression was proposed a century ago and recently regained experimental support. Results Herein, the hypothesis that hepatocellular carcinoma (HCC) leaves a

Externí odkaz: https://doaj.org/article/02925f251cc0446dadb0038618baf59c

The Matroid Cup Game

Autor: Sungjin Im, Rudy Zhou, Benjamin Moseley

Publikováno v: Operations Research Letters. 49:405-411

In this paper we introduce the Matroid Cup Game. This cup game generalizes the One- and p-Cup Games. We show that a natural greedy strategy maintains max fill O ( log ⁡ n ) in the Matroid Cup Game with mild resource augmentation. Further, we introd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f1a820b5a2c0a01a2773d4fffdacc15
https://doi.org/10.1016/j.orl.2021.04.005

Quantifying the polymerization dynamics of plant cortical microtubules using kymograph analysis

Autor: Rudy, Zhou, Han, Liu, Tao, Ju, Ram, Dixit

Publikováno v: Methods in cell biology. 160

The plant cortical microtubule array is a dynamic structure that confers cell shape and enables plants to alter their growth and development in response to internal and external cues. Cells use a variety of microtubule regulatory proteins to spatiall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30e981f592c596559d12db793e820340
https://pubmed.ncbi.nlm.nih.gov/32896322

Fetal glucocorticoid receptor (Nr3c1) deficiency alters the landscape of DNA methylation of murine placenta in a sex-dependent manner and is associated to anxiety-like behavior in adulthood

Autor: Florian Lapert, Rudy Zhou, Anna Macedo da Cruz, Paolo Sandrini, Laurence Lanfumey, Michaela Schmidt, Moshe Szyf, Renaud Massart, Marco A. Riva, Alessia Ludiro, Farida Vaisheva, Teresa Calzoni, Elad Lax, Michael Deuschle, Arne Mathias Ruder, David Cheishvili, Alessia Luoni, Christiane Brandwein, Peter Gass

Publikováno v: Translational Psychiatry
Translational Psychiatry, Vol 9, Iss 1, Pp 1-11 (2019)

Prenatal stress defines long-term phenotypes through epigenetic programming of the offspring. These effects are potentially mediated by glucocorticoid release and by sex. We hypothesized that the glucocorticoid receptor (Gr, Nr3c1) fashions the DNA m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97bd73473bf7150ed54463c4014c156
http://europepmc.org/articles/PMC6336883

DNA methylation controls unmethylated transcription start sites in the genome in trans

Autor: Steffan Christiansen, Anne-Sophie Pepin, Moshe Szyf, Rudy Zhou, Lauren Schmeltzer, Sergey Dymov, Daniel M Sapozhnikov, David Cheishvili, Rebecca Stochinsky

Publikováno v: Cheishvili, D, Christiansen, S, Stochinsky, R, Pepin, A-S, Sapozhnikov, D M, Zhou, R, Schmeltzer, L, Dymov, S & Szyf, M 2017, ' DNA methylation controls unmethylated transcription start sites in the genome in trans ', Epigenomics, vol. 9, no. 5, pp. 611-633 . https://doi.org/10.2217/epi-2016-0141

Aim: DNA methylation downregulates transcription. However, a large number of genes, which are unmethylated in the promoter region, are inactive. We tested the hypothesis that these genes are regulated by DNA methylation of upstream regulators. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87df976b94d4a20bcb83efed4394bd59
https://pure.au.dk/portal/da/publications/dna-methylation-controls-unmethylated-transcription-start-sites-in-the-genome-in-trans(cad080b3-6a04-4557-ac17-bfebd0600a5c).html