Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rudy Stuppard"'
Autor:
Gavin Pharaoh, Ethan L. Ostrom, Rudy Stuppard, Matthew Campbell, Jens Markus Borghardt, Michael Franti, Antonio Filareto, David J. Marcinek
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102770- (2023)
It is unclear whether mitochondrial dysfunction and redox stress contribute to impaired age-related muscle regenerative capacity. Here we characterized a novel compound, BI4500, that inhibits the release of reactive oxygen species (ROS) from the quin
Externí odkaz:
https://doaj.org/article/62e3683a27e14fe2beb4e7d309003588
Autor:
Anna A. Bakhtina, Gavin Pharaoh, Andrew D. Keller, Rudy Stuppard, David J. Marcinek, James E. Bruce
Genomic, transcriptomic, and proteomic approaches have been employed to gain insight into molecular underpinnings of aging in laboratory animals and in humans. However, protein function in biological systems is under complex regulation and includes f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f64bec227bc1df2f0176a7cef69650e
https://doi.org/10.1101/2022.06.24.497539
https://doi.org/10.1101/2022.06.24.497539
Autor:
Peter S. Rabinovitch, Huiliang Zhang, Rudy Stuppard, Matthew Campbell, Andrew Keller, Juan D. Chavez, Philip A. Kramer, David J. Marcinek, Gustavo Reyes, Xiaoting Tang, James E. Bruce
Publikováno v:
Proc Natl Acad Sci U S A
Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, cancer, neurodegenerative diseases, and the general aging process. Therapeutics that restore healthy mitochondrial function hold promise for tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44cca35af825dc8e5caec994a65d826
https://pubmed.ncbi.nlm.nih.gov/32554501
https://pubmed.ncbi.nlm.nih.gov/32554501
Autor:
David J. Marcinek, Rudy Stuppard, Rong Tian, Chi Fung Lee, James E. Bruce, Devin K. Schweppe, Juan D. Chavez, Gerald S. Shadel, Arianne Caudal, Shane E. Kruse
Publikováno v:
Proceedings of the National Academy of Sciences. 114:1732-1737
Mitochondrial protein interactions and complexes facilitate mitochondrial function. These complexes range from simple dimers to the respirasome supercomplex consisting of oxidative phosphorylation complexes I, III, and IV. To improve understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b1e0e7f5be73ea52ca9959c62447969
https://doi.org/10.1073/pnas.1617220114
https://doi.org/10.1073/pnas.1617220114
Autor:
Philip A. Kramer, David J. Marcinek, James E. Bruce, Matthew Campbell, Xiaoting Tang, Andrew Keller, Gustavo Reyes, Juan D. Chavez, Rudy Stuppard
Mitochondrial dysfunction underlies the etiology of a broad spectrum of diseases including heart disease, cancer, neurodegenerative diseases, and the general aging process. Therapeutics that restore healthy mitochondrial function hold promise for tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ed4ae3568b7341d1e0e8421496da91
Autor:
Marta L. Fiorotto, Troy A. Hornberger, Karyn A. Esser, Mark J. Fedele, Rudy Stuppard, Kevin E. Conley, Eva R. Chin
Publikováno v:
The Biochemical journal. 380(Pt 3)
In response to growth factors, mTOR (mammalian target of rapamycin) has been identified as a central component of the signalling pathways that control the translational machinery and cell growth. Signalling through mTOR has also been shown to be nece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a240e910958352922125ae79cbaaa4c
https://pubmed.ncbi.nlm.nih.gov/15030312
https://pubmed.ncbi.nlm.nih.gov/15030312
Autor:
Rudy Stuppard, Guy L. Odom, David J. Marcinek, Rong Tian, Haiwei Gu, Stephen C. Kolwicz, Sarah G. Nowakowski, Michael Regnier, Galina V. Flint, Daniel Raftery, Jeffrey S. Chamberlain
Publikováno v:
Biophysical Journal. (2):345a
Impaired systolic function resulting from acute injury, congenital defect, or aging can lead to cardiac complications and heart failure. Current therapies are unable to rescue cardiac function, but merely slow disease progression. We have demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8fbbcb5cbff679371e4893486a1302